Malnutrition results from qualitative or quantitative deficiency of dietary nutrient. Most cases of childhood malnutrition occur in Asia and Africa and are often associated with poverty, ignorance and concomitant childhood infectious diseases. The condition can be sub-classified into mild, moderate and severe malnutrition in relation to the standard reference values for age and sex based on the World Health Organization classification. Malnutrition leads to impaired physical, immunologic, neurologic and neurologic development.
This page contains ongoing trials listed on one of five clinical trial registries searched by REFINE. These resources are tagged and searchable according to nutritional problem, study interventions, country, study type, and research gaps. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.
A Prospective randomized controlled study to evaluate the efficacy of indigenously made fortified complementary food in children with Moderate Acute Malnutrition
This study aims to examine the improvement of linear growth of children in low resource settings through integrated nutrition, WASH, care and support interventions during the pre- and peri-conceptional period, pregnancy, and early childhood through a randomized controlled trial.
The aim of this study is to find out whether rice-based, lactose-free F-75 can reduce diarrhoea in hospitalized children with severe acute malnutrition. Participants are treated according to the latest WHO guideline for management of severe acute malnutrition, and are randomly allocated to receive one of four different F-75 formulae with either rice flour or maltodextrin as the main carbohydrate source and either the standard level of lactose or no lactose. The duration of the stabilization phase is typically around one week.
The aim of this study is to examine whether or not consuming flour made from the high zinc grain has a beneficial impact on the zinc status of zinc-deficient women living in a rural community in North West Pakistan. Participating families are randomly allocated to consume either the high zinc grain or the standard grain for eight weeks. The families switch over after eight weeks. Blood and hair zinc concentration are measured, along with new indicators of zinc status such as markers of DNA damage and a new portable laser technique for measuring nail zinc concentration.
Objectives: To investigate whether a nut fish based food and dietary supplementation delivered to pregnant mothers with health education would benefit maternal and birth outcomes compared with the government standard of care.
Design. A randomized control trial will be implemented in rural community in Indonesia.
- To examine the impact of malnutrition on development quotient of children
- To determine the effectiveness of Ready to Use Therapeutic Food (RUTF) in improving the development quotient of severe acute malnourished children under five year of age.
- To investigate the outcome of Vitamin D therapeutic doses intervention with RUTF rehabilitation on growth and development of malnourished children.
Objective: To evaluate the effectiveness of RUSFs in improving childhood length for age scores.
Ready-to-Use Therapeutic Foods (RUTF) are high-energy, lipid-based spreads that can be used for the treatment of malnutrition. To provide government and international agencies with an alternative to the standard treatment, this study aims to compare an alternative ready-to-use therapeutic food (RUTF) with the standard RUTF.
The proposed study is an extension study to two ongoing double blind, randomized, placebo-controlled studies evaluating the effect of gender-specific nutritional supplementation on growth of short and lean adolescent boys and girls. The aim of the current study is to extend these short term double blind, randomized, placebo controlled studies (one in boys and one in girls) and to add an extension study, which will evaluate the long term effect of the gender specific nutritional supplementation on final height.