Effects of EED on Zn absorption and retention in children from a MNP (ZEED2)

Primary Investigator

  • Nancy Krebs

Study Period

November 2015 - March 2017

Study Description

The overall objective is to determine the impact of EED on total daily zinc absorption of young Bangladeshi children (18-24 months of age) in an austere setting with high rates of diarrhea, stunting, and micro-nutrient deficiencies.

Study Arms

  • Active Comparator: Micronutrient Powder (MNP) + 15 mg Zn 1 sachet of Micronutrient Powder (MNP) + 15 mg: Zn will be added to a single meal on study day 8
  • Active Comparator: MNP + 10 mg Zn; 1 sachet of MNP + 10 mg Zn will be added to a single meal on study day 8
  • Active Comparator: MNP + 5 mg Zn; 1 sachet of MNP + 5 mg Zn will be added to a single meal on study day 8
  • Placebo Comparator: MNP without Zn; 1 sachet of MNP without Zn will be added to a single meal on study day 8

Primary Outcomes

  • Total daily absorbed zinc (TAZ): Measured during the meal to determine the effects of EED on zinc absorption.

Study Interventions

  • Environmental enteric dysfunction (EED)
  • Micronutrient powders (MNP)

Research Gaps

  • Composition

    Which ingredients offer the best prevention or treatment for undernutrition?

  • Effectiveness

    How well do different food compositions and interventions prevent or treat undernutrition, when implemented "on the ground"?

Study Population

80