Published Studies

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 26 - 50 of 60 Results
Dewey, K. G., Arimond, M.. "Lipid-based nutrient supplements: how can they combat child malnutrition? ." PLoS Medicine 9 , no. 9 (2012) : e1001314
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • SAM
  • MAM
Scherbaum, V., Purwestri, R. C., Stuetz, W., Inayati, D. A., Suryantan, J., Bloem, M. A., Biesalski, H. K.. "Locally produced cereal/nut/legume-based biscuits versus peanut/milk-based spread for treatment of moderately to mildly wasted children in daily programmes on Nias Island, Indonesia: an issue of acceptance and compliance? ." Asia Pacific Journal of Clinical Nutrition 24 , no. 1 (2015) : 152
Study Interventions
  • Animal-source protein
  • Behavior change communication (BCC)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
  • Other
Research Gaps
  • Acceptability
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • MAM
Ackatia-Armah, R. S., McDonald, C. M., Doumbia, S., Erhardt, J. G., Hamer, D. H., Brown, K. H.. "Malian children with moderate acute malnutrition who are treated with lipid-based dietary supplements have greater weight gains and recovery rates than those treated with locally produced cereal-legume products: a community-based, cluster-randomized trial ." American Journal of Clinical Nutrition 101 , no. 3 (2015) : 632-645
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Tang, M., Sheng, X. Y., Krebs, N. F., Hambidge, K. M.. "Meat as complementary food for older breastfed infants and toddlers: a randomized, controlled trial in rural China ." Food and Nutrition Bulletin 35 , no. 4 Suppl (2014) : S188-192
Study Interventions
  • Animal-source protein
  • Locally produced
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Perignon, M., Fiorentino, M., Kuong, K., Chamnan, C., Parker, M., Burja, K., Berger, J., Wieringa, F. T.. "Multi-micronutrient fortified rice improved vitamin A status of Cambodian school children ." European Journal of Nutrition & Food Safety 5 , no. 5 (2015) : 832-833
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
Nutritional Problems being Studied
  • Stunted
Simpore, J., Kabore, F., Zongo, F., Dansou, D., Bere, A., Pignatelli, S., Biondi, D. M., Ruberto, G., Musumeci, S.. "Nutrition rehabilitation of undernourished children utilizing Spiruline and Misola ." Nutrition Journal 5 , no. 3 (2006)
Study Interventions
  • Locally produced
  • Other
Research Gaps
  • Composition
  • Innovation
Nutritional Problems being Studied
  • Stunted
Kerac, M., Bunn, J., Seal, A., Thindwa, M., Tomkins, A., Sadler, K., Bahwere, P., Collins, S.. "Probiotics and prebiotics for severe acute malnutrition (PRONUT study): a double-blind efficacy randomised controlled trial in Malawi ." The Lancet 374 , no. 9684 (2009) : 136-144
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Other
Research Gaps
  • Composition
  • Innovation
Nutritional Problems being Studied
  • SAM
Mangani, C., Cheung, Y. B., Maleta, K., Phuka, J., Thakwalakwa, C., Dewey, K., Manary, M., Puumalainen, T., Ashorn, P.. "Providing lipid-based nutrient supplements does not affect developmental milestones among Malawian children ." Acta Paediatrica 103 , no. 1 (2014) : e17-26
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Maleta, K. M., Phuka, J., Alho, L., Cheung, Y. B., Dewey,K. G., Ashorn, U., Phiri, N., Phiri, T. E., Vosti, S. A., Zeilani, M., Kumwenda, C., Bendabenda, J., Pulakka, A., Ashorn, P.. "Provision of 10–40 g/d lipid-based nutrient supplements from 6 to 18 months of age does not prevent linear growth faltering in Malawi ." The Journal of Nutrition 145 , no. 8 (2015) : 1909-15
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Iannotti, L. L., Henretty, N. M., Delnatus, J. R., Previl, W., Stehl, T., Vorkoper, S., Bodden, J., Maust, A., Smidt, R., Nash, M. L., Tamimie, C. A., Owen, B. C., Wolff, P. B.. "Ready-to-use supplementary food increases fat mass and BMI in Haitian school-aged children ." The Journal of Nutrition 145 , no. 4 (2015) : 813-822
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Other
Research Gaps
  • Composition
Nutritional Problems being Studied
  • Stunted
Jones, K. D., Ali, R., Khasira, M. A., Odera, D., West, A. L., Koster, G., Akomo, P., Talbert, A. W., Goss, V. M., Ngari, M., Thitiri, J., Ndoro, S., Knight, M. A. G., Omollo, K., Ndungu, A., Mulongo, M. M., Bahwere, P., Fegan, G., Warner, J. O., Postle, A. D., Collins, S., Calder, P. C., Berkley, J. A.. "Ready-to-use therapeutic food with elevated n-3 polyunsaturated fatty acid content, with or without fish oil, to treat severe acute malnutrition: a randomized controlled trial ." BMC Medicine 13 , no. 1 (2015) : 93
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Other
Research Gaps
  • Composition
  • Innovation
Nutritional Problems being Studied
  • SAM
Hess, S. Y., Abbeddou, S., Jimenez, E. Y., Somé, J. W., Vosti, Stephen A, Ouédraogo, Z. P., Guissou, R. M., Ouédraogo, J., Brown, K. H.. "Small-quantity lipid-based nutrient supplements, regardless of their zinc content, increase growth and reduce the prevalence of stunting and wasting in young burkinabe children: a cluster-randomized trial ." PloS One 10 , no. 3 (2015) : e0122242
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • GAM
Adu-Afarwuah, S., Lartey, A., Okronipa, H., Ashorn, P., Peerson, J. M., Arimond, M., Ashorn, U., Zeilani, M., Vosti, S., Dewey, K. G.. "Small-quantity, lipid-based nutrient supplements provided to women during pregnancy and 6 mo postpartum and to their infants from 6 mo of age increase the mean attained length of 18-mo-old children in semi-urban Ghana: a randomized controlled trial ." The American Journal of Clinical Nutrition 104 , no. 3 (2016) : 797-808
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • GAM
Matilsky, D. K., Maleta, K., Castleman, T., Manary, M. J.. "Supplementary feeding with fortified spreads results in higher recovery rates than with a corn/soy blend in moderately wasted children ." The Journal of Nutrition 139 , no. 4 (2009) : 773-778
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Abizari, A., Moretti, D., Zimmermann, M. B., Armar-Klemesu, M., Brouwer, I. D.. "Whole cowpea meal fortified with NaFeEDTA reduces iron deficiency among Ghanaian school children in a malaria endemic area ." The Journal of Nutrition 142 , no. 10 (2012) : 1836-1842
Study Interventions
  • Fortified blended foods (FBF)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
Nutritional Problems being Studied
  • Stunted
Arimond, M., Zeilani, M., Jungjohann, S., Brown, K. H., Ashorn, P., Allen, L. H., Dewey, K. G.. "Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS) Project ." Maternal & Child Nutrition 11 , no. S4 (2015) : 31-61
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Stunted
Chavasit, V., Porasuphatana, S., Suthutvoravut, U., Zeder, C., Hurrell, R.. "Iron bioavailability in 8-24-month-old Thai children from a micronutrient-fortified quick-cooking rice containing ferric ammonium citrate or a mixture of ferrous sulphate and ferric sodium ethylenediaminetetraacetic acid ." Maternal & Child Nutrition 11 , no. S4 (2015) : 179-187
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Irena, A., Bahwere, P., Owino, V., Diop, E. I., Bachmann, M., Mbwili-Muleya, C., Dibari, F., Sadler, K., Collins, S.. "Comparison of the effectiveness of a milk-free soy-maize-sorghum-based ready-to-use therapeutic food to standard ready-to-use therapeutic food with 25% milk in nutrition management of severely acutely malnourished Zambian children: an equivalence non-blinded cluster randomised controlled trial ." Maternal & Child Nutrition 11 , no. S4 (2015) : 105-119
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Cost
  • Efficacy
Nutritional Problems being Studied
  • SAM
Wang, A. Z., Shulman, R. J., Crocker, A. H., Thakwalakwa, C., Maleta, K. M., Devaraj, S., Manary, M., Trehan, I.. "A combined intervention of zinc, multiple micronutrients, and Albendazole does not ameliorate environmental enteric dysfunction or stunting in rural Malawian children in a double-blind randomized controlled trial ." The Journal of Nutrition 147 , no. 1 (2017) : 97-103
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Bhandari, N., Mohan, S. B., Bose, A., Iyengar, S. D., Taneja, S., Mazumder, S., Pricilla, R. A., Iyengar, K., Sachdev, H. S., Mohan, V. R., Suhalka, V., Yoshida, S., Martines, J., Bahl, R.. "Efficacy of three feeding regimens for home-based management of children with uncomplicated severe acute malnutrition: a randomised trial in India ." BMJ Global Health 1 , no. e000144 (2016)
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Other
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • SAM
Fatima, S., Malkova, D., Wright, C., Gerasimidis, K.. "Impact of therapeutic food compared to oral nutritional supplements on nutritional outcomes in mildly underweight healthy children in a low-medium income society ." Clinical Nutrition (2017)
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Bahwere, P., Akomo, P., Mwale, M., Murakami, H., Banda, C., Kathumba, S., Banda, C., Jere, S., Sadler, K., Collins, S.. "Soya, maize, and sorghum-based ready-to-use therapeutic food with amino acid is as efficacious as the standard milk and peanut paste-based formulation for the treatment of severe acute malnutrition in children: A noninferiority individually randomized controlled efficacy clinical trial in Malawi. ." American Journal of Clinical Nutrition (2017)
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • SAM
Delimont, N. M., Alavi, S., Lindshield, B.. "New formulations for fortified-blended foods: the MFFAPP Tanzania efficacy trial ." The FASEB Journal 31 , no. 1 (2017) : Supplement 786.15
Study Interventions
  • Fortified blended foods (FBF)
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
Kampstra, N. A., Van Hoan, N., Koenders, D. J. P. C., Schoop, R., Broersen, C. B., Mouquet-Rivier, C., Traore, T., Bruins, M. J., de Pee, S.. "Energy and nutrient intake increased by 47–67% when amylase was added to fortified blended foods—a study among 12- to 35-month-old Burkinabe children ." Maternal & Child Nutrition (2017)
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Stunted
  • GAM
Unger, S. A., Drammeh, S., Hasan, J., Ceesay, K., Sinjanka, E., Beyai, S., Sonko, B., Dondeh, B. L., Filford, A. J., Moore, S. E., Prentice, A. M.. "Impact of fortified versus unfortified lipid-based supplements on morbidity and nutritional status: A randomised double-blind placebo-controlled trial in ill Gambian children ." PLoS Medicine 14 , no. 8 (2017) : e1002377
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted