Published Studies

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 158 Results
Ryan, K. N., Adams, K. P., Vosti, S. A., Ordiz, M. I., Cimo, E. D., Manary, M. J.. "A comprehensive linear programming tool to optimize formulations of ready-to-use therapeutic foods: an application to Ethiopia ." The American Journal of Clinical Nutrition 100 , no. 6 (2014) : 1551-1558
Study Interventions
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • SAM
Ramírez-Luzuriaga, M. J., Unar-Munguía, M., Rodríguez-Ramírez, S., Rivera, J. A., González de Cosío, T.. "A food transfer program without a formal education component modifies complementary feeding practices in poor rural Mexican communities ." The Journal of Nutrition 146 , no. 1 (2016) : 107-13
Study Interventions
  • Animal-source protein
  • Behavior change communication (BCC)
  • Cash transfer
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
Thakwalakwa, C., Ashorn, P., Phuka, J., Cheung, Y. B., Briend, A., Puumalainen, T., Maleta, K.. "A lipid-based nutrient supplement but not corn-soy blend modestly increases weight gain among 6-to 18-month-old moderately underweight children in rural Malawi ." The Journal of Nutrition 140 , no. 11 (2010) : 2008-2013
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
LaGrone, L. N., Trehan, I., Meuli, G. J., Wang, R. J., Thakwalakwa, C., Maleta, K., Manary, M. J.. "A novel fortified blended flour, corn-soy blend "plus-plus," is not inferior to lipid-based ready-to-use supplementary foods for the treatment of moderate acute malnutrition in Malawian children ." The American Journal of Clinical Nutrition 95 , no. 1 (2012) : 212-9
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Batra, P., Schlossman, N., Balan, I., Pruzensky, W., Balan, A., Brown, C., Gamache, M. G., Schleicher, M. M., Braima de Sa, A., Saltzman, E., Wood, L., Roberts, S. B.. "A randomized controlled trial offering higher- compared with lower-dairy second meals daily in preschools in Guinea-Bissau demonstrates an attendance-dependent increase in weight gain for both meal types and an increase in mid-upper arm circumference ." The Journal of Nutrition 146 , no. 1 (2015) : 124-132
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Stunted
  • MAM
Mangani, C., Manary, M., Alho, L., Ashorn, P.. "A single-centre, randomized, single-blind, parallel group clinical trial in rural Malawi, testing the growth promoting effect of long-term complementary feeding of infants with a high-energy, micronutrient fortified spread ." FANTA Project (2012)
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • MAM
Thakwalakwa, C. M., Ashorn, P., Jawati, M., Phuka, J. C., Cheung, Y. B., Maleta, K. M.. "An effectiveness trial showed lipid-based nutrient supplementation but not corn-soya blend offered a modest benefit in weight gain among 6- to 18-month-old underweight children in rural Malawi ." Public Health Nutrition 15 , no. 9 (2012) : 1755-62
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Belachew, T., Nekatibeb, H.. "Assessment of outpatient therapeutic programme for severe acute malnutrition in three regions of Ethiopia ." East African Medical Journal 84 , no. 12 (2007) : 577-588
Study Interventions
  • Behavior change communication (BCC)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • SAM
Hidrobo, M., Hoddinott, J., Peterman, A., Margolies, A., Moreira, V.. "Cash, food, or vouchers? Evidence from a randomized experiment in northern Ecuador ." Journal of Development Economics 107 (2014) : 144-156
Study Interventions
  • Cash transfer
  • Other
Research Gaps
  • Cost
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Stunted
Tadesse, E., Ekström, E., Berhane, Y.. "Challenges in implementing the integrated community-based outpatient therapeutic program for severely malnourished children in rural Southern Ethiopia ." Nutrients 8 , no. 5 (2016) : 251
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • SAM
Chang, C. Y., Trehan, I., Wang, R. J., Thakwalakwa, C., Maleta, K., Deitchler, M., Manary, M. J.. "Children successfully treated for moderate acute malnutrition remain at risk for malnutrition and death in the subsequent year after recovery ." The Journal of Nutrition 143 , no. 2 (2013) : 215-220
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Mehta, B., Imran, A.. "Clinical and anthropometric profile of severe acute malnourished children on therapeutic intervention with WHO/UNICEF recommended therapeutic food ." International Journal of Science and Research 4 , no. 4 (2014) : 268-273
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • SAM
Portillo-Reyes, V., Pérez-García, M., Loya-Méndez, Y., Puente, A. E.. "Clinical significance of neuropsychological improvement after supplementation with omega-3 in 8–12 years old malnourished Mexican children: A randomized, double-blind, placebo and treatment clinical trial ." Research in Developmental Disabilities 35 , no. 4 (2014) : 861-870
Study Interventions
  • Other
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Burza, S., Mahajan, R., Marino, E., Sunyoto, T., Shandilya, C., Tabrez, M., Kumari, K., Mathew, P., Jha, A., Salse, N., Mishra, K. N., Marino, E.101. "Community-based management of severe acute malnutrition in India: new evidence from Bihar ." The American Journal of Clinical Nutrition 101 , no. 4 (2015) : 847-859
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • SAM
Marron, B., Green, J., Jayson, L., Suri, D., Marcus, S., Boiteau, J., Manary, M., Webb, P., Rogers, B.. "Comparison of four different supplementary foods in the treatment of moderate acute malnutrition (MAM) in children under five in Sierra Leone ." The FASEB Journal 29 , no. 1 (2015)
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Langendorf, C., Roederer, T., de Pee, S., Brown, D., Doyon, S., Mamaty, A., Touré, L. W., Manzo, M. L., Grais, R. F.. "Preventing acute malnutrition among young children in crises: A prospective intervention study in Niger ." PLOS Medicine (2012)
Study Interventions
  • Animal-source protein
  • Cash transfer
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
  • Other
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • SAM
  • MAM
Phuka, J. C., Gladstone, M., Maleta, K., Thakwalakwa, C., Cheung, Y. B., Briend, A., Manary, M. J., Ashorn, P.. "Developmental outcomes among 18‐month‐old Malawians after a year of complementary feeding with lipid‐based nutrient supplements or corn‐soy flour ." Maternal & Child Nutrition 8 , no. 2 (2012) : 239-248
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Ruel, M. T., Menon, P., Loechl, C., Pelto, G.. "Donated fortified cereal blends improve the nutrient density of traditional complementary foods in Haiti, but iron and zinc gaps remain for infants ." Food and Nutrition Bulletin 25 , no. 4 (2004) : 361-376
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Stunted
Lebenthal, Y., Yackobovitch-Gavan, M., Lazar, L., Shalitin, S., Tenenbaum, A., Shamir, R., Phillip, M.. "Effect of a nutritional supplement on growth in short and lean prepubertal children: a prospective, randomized, double-blind, placebo-controlled study ." The Journal of Pediatrics 165 , no. 6 (2014) : 1190-1193.e1
Study Interventions
  • Animal-source protein
  • Other
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Christian, P., Shaikh, S., Shamim, A. A., Mehra, S., Wu, L., Merrill, R. D., Klemm, R., Schulze, K., Pee, S., Ahmed, T.. "Effect of fortified complementary food supplementation on child growth in rural Bangladesh: A cluster-randomized trial ." The FASEB Journal 29 , no. 1 Supplement (2015) : 120.5
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • GAM
Omollo, S. A.. "Effect of improved complementary foods on lean body mass, essential fatty acids, and gross motor development of Kenyan infants ." University of Nairobi Institute of Tropical and Infectious Diseases (2014)
Study Interventions
  • Fortified blended foods (FBF)
  • Locally produced
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • MAM
Grellety, E., Shepherd, S., Roederer, T., Manzo, M. L., Doyon, S., Ategbo, E., Grais, R. F.. "Effect of mass supplementation with ready-to-use supplementary food during an anticipated nutritional emergency ." PloS One 7 , no. 9 (2012) : e44549
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Stunted
  • GAM
Isanaka, S., Nombela, N.ohelly, Djibo, A., Poupard, M., Van Beckhoven, D., Gaboulaud, V., Guerin, P. J., Grais, R. F.. "Effect of preventive supplementation with ready-to-use therapeutic food on the nutritional status, mortality, and morbidity of children aged 6 to 60 months in Niger: a cluster randomized trial. ." Journal of the American Medical Association 301 , no. 3 (2009) : 277-85
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • GAM
Prudhon, C., Langendorf, C., Roederer, T., Doyon, S., Mamaty, A., Woi-Messe, L., Manzo, M. L., de Pee, S., Grais, R. F.. "Effect of ready-to-use foods for preventing child undernutrition in Niger: analysis of a prospective intervention study over 15 months of follow-up ." Maternal & Child Nutrition 13 , no. 1 (2016)
Study Interventions
  • Cash transfer
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • SAM
  • MAM
van der Kam, S., Roll, S., Swarthout, T., Edyegu-Otelu, G., Matsumoto, A., Kasujja, F. X., Casademont, C., Shanks, L., Salse-Ubach, N.. "Effect of short-term supplementation with ready-to-use therapeutic food or micronutrients for children after illness for prevention of malnutrition: a randomised controlled trial in Uganda ." PLoS Medicine 13 , no. 2 (2016) : e1001951
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM