Published Studies

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 19 of 19 Results
Ryan, K. N., Adams, K. P., Vosti, S. A., Ordiz, M. I., Cimo, E. D., Manary, M. J.. "A comprehensive linear programming tool to optimize formulations of ready-to-use therapeutic foods: an application to Ethiopia ." The American Journal of Clinical Nutrition 100 , no. 6 (2014) : 1551-1558
Study Interventions
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • SAM
Phuka, J., Ashorn, U., Ashorn, P., Zeilani, M., Cheung, Y. B., Dewey, K. G., Manary, M., Maleta, K.. "Acceptability of three novel lipid-based nutrient supplements among Malawian infants and their caregivers ." Maternal & Child Nutrition 7 , no. 4 (2011) : 368-377
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
  • Composition
  • Innovation
Nutritional Problems being Studied
  • MAM
Langendorf, C., Roederer, T., de Pee, S., Brown, D., Doyon, S., Mamaty, A., Touré, L. W., Manzo, M. L., Grais, R. F.. "Preventing acute malnutrition among young children in crises: A prospective intervention study in Niger ." PLOS Medicine (2012)
Study Interventions
  • Animal-source protein
  • Cash transfer
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
  • Other
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • SAM
  • MAM
Skau, J. K. H., Touch, B., Chhoun, C., Chea, M., Unni, U. S., Makurat, J., Filteau, S., Wieringa, F. T., Dijkhuizen, M. A., Ritz, C., Wells, J. C., Berger, J., Friis, H., Michaelsen, K. F., Roos, N.. "Effects of animal source food and micronutrient fortification in complementary food products on body composition, iron status, and linear growth: A randomized trial in Cambodia ." The American Journal of Clinical Nutrition 101 , no. 4 (2015) : 742-751
Study Interventions
  • Fortified blended foods (FBF)
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
Amegovu, Andrew Kiri, Ochola, Sophie, Ogwok, Patrick, Yiga, Peter, Musalima, Juliet, Juliana, Mandha. "Efficacy of sorghum peanut blend and corn soy blend plus in the treatment of moderate acute malnutrition in children aged 6–59 months in Karamoja, Uganda: a cluster randomized trial ." Nutrition & Dietary Supplements 6 (2014) : 75-84
Study Interventions
  • Fortified blended foods (FBF)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Composition
  • Innovation
Nutritional Problems being Studied
  • MAM
Hsieh, J. C., Liu, L., Zeilani, M., Ickes, S., Trehan, I., Maleta, K., Craig, C., Thakwalakwa, C., Singh, L., Brenna, J. T., Manary, M. J.. "High oleic ready-to-use therapeutic food maintains docosahexaenoic acid status in severe malnutrition: A randomized, blinded trial ." Journal of Pediatric Gastroenterology and Nutrition 61 , no. 1 (2015) : 138-143
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • SAM
Nguefack, F., Adjahoung, C. A., Keugoung, B., Kamgaing, N., Dongmo, R.. "Hospital management of severe acute malnutrition in children with F-75 and F-100 alternative local preparations: results and challenges ." The Pan African Medical Journal 21 (2015) : 329
Study Interventions
  • Animal-source protein
  • Locally produced
Research Gaps
  • Composition
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • SAM
Scherbaum, V., Purwestri, R. C., Stuetz, W., Inayati, D. A., Suryantan, J., Bloem, M. A., Biesalski, H. K.. "Locally produced cereal/nut/legume-based biscuits versus peanut/milk-based spread for treatment of moderately to mildly wasted children in daily programmes on Nias Island, Indonesia: an issue of acceptance and compliance? ." Asia Pacific Journal of Clinical Nutrition 24 , no. 1 (2015) : 152
Study Interventions
  • Animal-source protein
  • Behavior change communication (BCC)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
  • Other
Research Gaps
  • Acceptability
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • MAM
Simpore, J., Kabore, F., Zongo, F., Dansou, D., Bere, A., Pignatelli, S., Biondi, D. M., Ruberto, G., Musumeci, S.. "Nutrition rehabilitation of undernourished children utilizing Spiruline and Misola ." Nutrition Journal 5 , no. 3 (2006)
Study Interventions
  • Locally produced
  • Other
Research Gaps
  • Composition
  • Innovation
Nutritional Problems being Studied
  • Stunted
Kerac, M., Bunn, J., Seal, A., Thindwa, M., Tomkins, A., Sadler, K., Bahwere, P., Collins, S.. "Probiotics and prebiotics for severe acute malnutrition (PRONUT study): a double-blind efficacy randomised controlled trial in Malawi ." The Lancet 374 , no. 9684 (2009) : 136-144
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Other
Research Gaps
  • Composition
  • Innovation
Nutritional Problems being Studied
  • SAM
Jones, K. D., Ali, R., Khasira, M. A., Odera, D., West, A. L., Koster, G., Akomo, P., Talbert, A. W., Goss, V. M., Ngari, M., Thitiri, J., Ndoro, S., Knight, M. A. G., Omollo, K., Ndungu, A., Mulongo, M. M., Bahwere, P., Fegan, G., Warner, J. O., Postle, A. D., Collins, S., Calder, P. C., Berkley, J. A.. "Ready-to-use therapeutic food with elevated n-3 polyunsaturated fatty acid content, with or without fish oil, to treat severe acute malnutrition: a randomized controlled trial ." BMC Medicine 13 , no. 1 (2015) : 93
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Other
Research Gaps
  • Composition
  • Innovation
Nutritional Problems being Studied
  • SAM
Adu-Afarwuah, S., Lartey, A., Okronipa, H., Ashorn, P., Peerson, J. M., Arimond, M., Ashorn, U., Zeilani, M., Vosti, S., Dewey, K. G.. "Small-quantity, lipid-based nutrient supplements provided to women during pregnancy and 6 mo postpartum and to their infants from 6 mo of age increase the mean attained length of 18-mo-old children in semi-urban Ghana: a randomized controlled trial ." The American Journal of Clinical Nutrition 104 , no. 3 (2016) : 797-808
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • GAM
Bhandari, N., Mohan, S. B., Bose, A., Iyengar, S. D., Taneja, S., Mazumder, S., Pricilla, R. A., Iyengar, K., Sachdev, H. S., Mohan, V. R., Suhalka, V., Yoshida, S., Martines, J., Bahl, R.. "Efficacy of three feeding regimens for home-based management of children with uncomplicated severe acute malnutrition: a randomised trial in India ." BMJ Global Health 1 , no. e000144 (2016)
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Other
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • SAM
Bahwere, P., Akomo, P., Mwale, M., Murakami, H., Banda, C., Kathumba, S., Banda, C., Jere, S., Sadler, K., Collins, S.. "Soya, maize, and sorghum-based ready-to-use therapeutic food with amino acid is as efficacious as the standard milk and peanut paste-based formulation for the treatment of severe acute malnutrition in children: A noninferiority individually randomized controlled efficacy clinical trial in Malawi. ." American Journal of Clinical Nutrition (2017)
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • SAM
Delimont, N. M., Alavi, S., Lindshield, B.. "New formulations for fortified-blended foods: the MFFAPP Tanzania efficacy trial ." The FASEB Journal 31 , no. 1 (2017) : Supplement 786.15
Study Interventions
  • Fortified blended foods (FBF)
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
Isanka, S., Roederer, T., Djibo, A., Luquero, F. J., Nombela, N., Guerin, P. J., Grais, R. F.. "Reducing wasting in young children with preventive supplementation: a cohort study in Niger ." Pediatrics 126 , no. 2 (2010)
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • GAM
Lin, C. A., Manary, M. J., Maleta, K., Briend, A., Ashorn, P.. "An energy-dense complementary food is associated with a modest increase in weight gain when compared with a fortified porridge in Malawian children aged 6–18 months ." Journal of Nutrition 138 (2008) : 593-598
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • GAM
Ackatia-Armah, R. S., McDonald, C., Doumbia, S., Brown, K. H.. "Effect of selected dietary regimens on recovery from moderate acute malnutrition in young Malian children ." The FASEB Journal 26 , no. 1 (2012)
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • MAM
Dube, B., Rongsen, T., Mazumder, S., Taneja, S., Rafiqui, F., Bhandari, N., Bhan, M. K.. "Comparison of ready-to-use therapeutic food with cereal legume-based Khichri among malnourished children ." Indian Pediatrics 46 (2009) : 383-388
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
Research Gaps
  • Acceptability
  • Composition
  • Innovation
Nutritional Problems being Studied
  • MAM