Published Studies

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!



Antibiotics as part of the management of severe acute malnutrition

Trehan, I., Goldbach, H. S., LaGrone, L. N., Meuli, G. J., Wang, R. J., Maleta, K. M., Manary, M. J.. "Antibiotics as part of the management of severe acute malnutrition." New England Journal of Medicine 368 , no. 5 (2013) : 425-435
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Innovation
Countries
  • Malawi
Nutritional Problems
  • SAM

Assessment of outpatient therapeutic programme for severe acute malnutrition in three regions of Ethiopia

Belachew, T., Nekatibeb, H.. "Assessment of outpatient therapeutic programme for severe acute malnutrition in three regions of Ethiopia." East African Medical Journal 84 , no. 12 (2007) : 577-588
Study Interventions
  • Behavior change communication (BCC)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Countries
  • Ethiopia
Nutritional Problems
  • SAM

Assessment of the effectiveness of a small quantity lipid-based nutrient supplement on reducing anaemia and stunting in refugee populations in the Horn of Africa: Secondary data analysis

Style, S., Tondeur, M., Grijalva-Eternod, C., Pringle, J., Kassim, I., Wilkinson, C., Oman, A., Dolan, C., Spiegel, P., Seal, A.. "Assessment of the effectiveness of a small quantity lipid-based nutrient supplement on reducing anaemia and stunting in refugee populations in the Horn of Africa: Secondary data analysis." PLoS One 12 , no. 6 (2017)
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Countries
  • Djibouti
  • Kenya
Nutritional Problems
  • Stunted

Cash, food, or vouchers? Evidence from a randomized experiment in northern Ecuador

Hidrobo, M., Hoddinott, J., Peterman, A., Margolies, A., Moreira, V.. "Cash, food, or vouchers? Evidence from a randomized experiment in northern Ecuador." Journal of Development Economics 107 (2014) : 144-156
Study Interventions
  • Cash transfer
  • Other
Research Gaps
  • Cost
  • Effectiveness
  • Use
Countries
  • Ecuador
Nutritional Problems
  • Stunted

Catch-up growth in children with severe acute malnutrition: comparison of two therapeutic feeding approaches at a district hospital, South Africa

Steenkamp, L., Nomvete, A., Venter, D.. "Catch-up growth in children with severe acute malnutrition: comparison of two therapeutic feeding approaches at a district hospital, South Africa." Africa Journal of Nursing and Midwifery 17 , no. 2 (2016)
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Efficacy
Countries
  • South Africa
Nutritional Problems
  • SAM

Caterpillar cereal as a potential complementary feeding product for infants and young children: nutritional content and acceptability

Bauserman, M., Lokangaka, A., Kodondi, K., Gado, J., Viera, A. J., Bentley, M. E., Engmann, C., Tshefu, A., Bose, C.. "Caterpillar cereal as a potential complementary feeding product for infants and young children: nutritional content and acceptability." Maternal & Child Nutrition 11 , no. Suppl 4 (2015) : 214-220
Study Interventions
  • Locally produced
Research Gaps
  • Acceptability
  • Innovation
Countries
  • Democratic Republic of the Congo
Nutritional Problems
  • Stunted
  • Pregnant & Lactating Women

Cereals and pulse-based ready-to-use therapeutic food as an alternative to the standard milk- and peanut paste-based formulation for treating severe acute malnutrition: a noninferiority, individually randomized controlled efficacy clinical trial

Bahwere, P., Balaluka, B., Wells, J. C., Mbiribindi, C. N., Sadler, K., Akomo, P., Dramaix-Wilmet, M., Collins, S.. "Cereals and pulse-based ready-to-use therapeutic food as an alternative to the standard milk- and peanut paste-based formulation for treating severe acute malnutrition: a noninferiority, individually randomized controlled efficacy clinical trial." The American Journal of Clinical Nutrition 103 , no. 4 (2016) : 1145-1161
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Composition
  • Efficacy
Countries
  • Zambia
Nutritional Problems
  • SAM

Challenges in implementing the integrated community-based outpatient therapeutic program for severely malnourished children in rural Southern Ethiopia

Tadesse, E., Ekström, E., Berhane, Y.. "Challenges in implementing the integrated community-based outpatient therapeutic program for severely malnourished children in rural Southern Ethiopia." Nutrients 8 , no. 5 (2016) : 251
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
  • Use
Countries
  • Ethiopia
Nutritional Problems
  • SAM

Changes in plasma phosphate during in-patient treatment of children with severe acute malnutrition: an observational study in Uganda

Namusoke, H., Hother, A., Rytter, M. J., Kæstel, P., Babirekere-Iriso, E., Fabiansen, C., Girma, T., Ritz, C., Michaelsen, K., Briend, A., Friis, H.. "Changes in plasma phosphate during in-patient treatment of children with severe acute malnutrition: an observational study in Uganda." The American Journal of Clinical Nutrition (2016)
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Efficacy
Countries
  • Uganda
Nutritional Problems
  • SAM

Changes in whole-blood PUFA and their predictors during recovery from severe acute malnutrition

Babirekere-Iriso, E., Mortensen, C. G., Mupere, E., Rytter, M. J., Namusoke, H., Michaelsen, K. F., Briend, A., Stark, K. D., Friis, H., Lauritzen, L.. "Changes in whole-blood PUFA and their predictors during recovery from severe acute malnutrition." The British Journal of Nutrition 115 , no. 10 (2016) : 1730-9
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Efficacy
Countries
  • Uganda
Nutritional Problems
  • SAM

Children successfully treated for moderate acute malnutrition remain at risk for malnutrition and death in the subsequent year after recovery

Chang, C. Y., Trehan, I., Wang, R. J., Thakwalakwa, C., Maleta, K., Deitchler, M., Manary, M. J.. "Children successfully treated for moderate acute malnutrition remain at risk for malnutrition and death in the subsequent year after recovery." The Journal of Nutrition 143 , no. 2 (2013) : 215-220
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Countries
  • Malawi
Nutritional Problems
  • MAM

Clinical and anthropometric profile of severe acute malnourished children on therapeutic intervention with WHO/UNICEF recommended therapeutic food

Mehta, B., Imran, A.. "Clinical and anthropometric profile of severe acute malnourished children on therapeutic intervention with WHO/UNICEF recommended therapeutic food." International Journal of Science and Research 4 , no. 4 (2014) : 268-273
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Effectiveness
Countries
  • India
Nutritional Problems
  • SAM

Clinical significance of neuropsychological improvement after supplementation with omega-3 in 8–12 years old malnourished Mexican children: A randomized, double-blind, placebo and treatment clinical trial

Portillo-Reyes, V., Pérez-García, M., Loya-Méndez, Y., Puente, A. E.. "Clinical significance of neuropsychological improvement after supplementation with omega-3 in 8–12 years old malnourished Mexican children: A randomized, double-blind, placebo and treatment clinical trial." Research in Developmental Disabilities 35 , no. 4 (2014) : 861-870
Study Interventions
  • Other
Research Gaps
  • Effectiveness
Countries
  • Mexico
Nutritional Problems
  • MAM

Combined protocol for SAM/MAM treatment: The ComPAS study

Bailey, J., Chase, R., Kerac, M., Briend, A., Manary, M., Opondo, C., Gallagher, M., Kim, A.. "Combined protocol for SAM/MAM treatment: The ComPAS study." ENN Online Field Exchange No. 53 (2016)
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Countries
  • Pakistan
  • South Sudan
  • Yemen
  • Chad
  • Kenya
Nutritional Problems
  • SAM
  • MAM

Community-based management of child malnutrition in Zambia: HIV/AIDS infection and other risk factors on child survival

Moramarco, S., Amerio, G., Ciarlantini, C., Chipoma, J. K., Simpungwe, M. K., Nielsen-Saines, K., Palombi, L., Buonomo, E.. "Community-based management of child malnutrition in Zambia: HIV/AIDS infection and other risk factors on child survival." International Journal of Environmental Research and Public Health 13 , no. 7 (2016)
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Countries
  • Zambia
Nutritional Problems
  • SAM
  • MAM