Published Studies

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Nguefack, F., Adjahoung, C. A., Keugoung, B., Kamgaing, N., Dongmo, R.. "Hospital management of severe acute malnutrition in children with F-75 and F-100 alternative local preparations: results and challenges ." The Pan African Medical Journal 21 (2015) : 329
Study Interventions
  • Animal-source protein
  • Locally produced
Research Gaps
  • Composition
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • SAM
Kodish, S., Aburto, N., Hambayi, M. N., Kennedy, C., Gittelsohn, J.. "Identifying the sociocultural barriers and facilitating factors to nutrition-related behavior change formative research for a stunting prevention program in Ntchisi, Malawi ." Food and Nutrition Bulletin 36 , no. 2 (2015) : 138-153
Study Interventions
  • Behavior change communication (BCC)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Stunted
Purwestri, R. C., Scherbaum, V., Inayati, D. A., Wirawan, N. N., Suryantan, J., Bloem, M. A., Pangaribuan, R. V., Stuetz, W., Hoffmann, V., Qaim, M., Biesalski, H. K., Bellows, A. C.. "Impact of daily versus weekly supply of locally produced ready-to-use food on growth of moderately wasted children on Nias Island, Indonesia ." ISRN Nutrition 2013 (2013) : 412145
Study Interventions
  • Locally produced
  • Plant-source protein
Research Gaps
  • Effectiveness
  • Innovation
  • Use
Nutritional Problems being Studied
  • MAM
Ningadalli, S. G., Angolkar, M., Herekar, V. R., Hirachand, A. D., Sah, J. K., Madikar, S.. "Impact of facility based dietary management on severe acute malnutrition in children aged 6 to 60 months admitted in nutritional rehabilitation centre of KLES’s Dr. Prabhakar Kore Hospital of Belagavi City - A longitudinal study ." International Journal of Science and Research 4 , no. 5 (2015) : 2133-2137
Study Interventions
  • Not Described
Research Gaps
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • SAM
Ickes, S. B., Adair, L. S., Brahe, C. A., Thirumurthy, H., Charles, B., Myhre, J. A., Bentley, M. E., Ammerman, A. S.. "Impact of lipid-based nutrient supplementation (LNS) on children's diet adequacy in Western Uganda ." Maternal & Child Nutrition 11 , no. S4 (2015) : 163-178
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • MAM
McNulty, Judiann, Harvey, Ruth, Tilford, Kathy. "Impact study report: Comparison of PM2A and MCHN approaches in SOUHARDO II ." (2015)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • GAM
Zhang, L., Voskuijl, W., Mouzaki, M., Groen, A. K., Alexander, J., Bourdon, C., Wang, A., Versloot, C. J., Di Giovanni, V., Wanders, R. J. A., Bandsma, R. H.. "Impaired bile acid homeostasis in children with severe acute malnutrition ." PLoS ONE 11 , no. 5 (2016) : e0155143
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • SAM
Stobaugh, H. C., Ryan, K. N., Kennedy, J. A., Grise, J. B., Crocker, A. H., Thakwalakwa, C., Litkowski, P. E., Maleta, K. M., Manary, M. J., Trehan, I.. "Including whey protein and whey permeate in ready-to-use supplementary food improves recovery rates in children with moderate acute malnutrition: a randomized, double-blind clinical trial ." American Journal of Clinical Nutrition 103 , no. 3 (2016) : 926-933
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
Nutritional Problems being Studied
  • MAM
Pongcharoen, T., Ramakrishnan, U., DiGirolamo, A.M., Winichagoon, P., Flores, R., Singkhornard, J., Martorell, R.. "Influence of prenatal and postnatal growth on intellectual functioning in school-aged children ." Archives of Pediatrics & Adolescent Medicine 166 , no. 5 (2012) : 411-416
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Caulfield, L. E., Huffman, S. L., Piwoz, E. G.. "Interventions to improve intake of complementary foods by infants 6 to 12 months of age in developing countries: impact on growth and on the prevalence of malnutrition and potential contribution to child survival ." Food and Nutrition Bulletin 2 , no. 2 (1999) : 183-200
Study Interventions
  • Not Described
Research Gaps
  • Effectiveness
  • Efficacy
  • Use
Nutritional Problems being Studied
  • Stunted
  • MAM
Cohuet, S., Marquer, C., Shepherd, S., Captier, V., Langendorf, C., Ale, F., Phelan, K., Manzo, M. L., Grais, R. F.. "Intra-household use and acceptability of Ready-to-Use-Supplementary-Foods distributed in Niger between July and December 2010 ." Appetite 59 , no. 3 (2012) : 698-705
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • GAM
Wang, R. J., Trehan, I., LaGrone, L. N., Weisz, A. J., Thakwalakwa, C. M., Maleta, K. M., Manary, M. J.. "Investigation of food acceptability and feeding practices for lipid nutrient supplements and blended flours used to treat moderate malnutrition ." Journal of Nutrition Education and Behavior 45 , no. 3 (2013) : 258-263
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • MAM
Cercamondi, C. I., Egli, I. M., Mitchikpe, E., Tossou, F., Hessou, J., Zeder, C., Hounhouigan, J. D., Hurrell, R. F.. "Iron bioavailability from a lipid-based complementary food fortificant mixed with millet porridge can be optimized by adding phytase and ascorbic acid but not by using a mixture of ferrous sulfate and sodium iron EDTA ." The Journal of Nutrition 143 , no. 8 (2013) : 1233-1239
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
Nutritional Problems being Studied
  • Stunted
Jaeggi, T., Kortman, G. A., Moretti, D., Chassard, C., Holding, P., Dostal, A., Boekhorst, J., Timmerman, H. M., Swinkels, D. W., Tjalsma, H., Njenga, J., Mwangi, A., Kvalsvig, J., Lacroix, C., Zimmermann, M. B.. "Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants ." Gut 64 , no. 5 (2015) : 731-42
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
Nutritional Problems being Studied
  • Stunted
Iannotti, L. L., Dulience, S. J. L., Green, J., Joseph, S., Francois, J., Antenor, M. L., Lesorogol, C., Mounce, J., Nickerson, N. M.. "Linear growth increased in young children in an urban slum of Haiti: a randomized controlled trial of a lipid-based nutrient supplement ." The American Journal of Clinical Nutrition 99 , no. 1 (2014) : 198-208
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Stunted
Adu-Afarwuah, S., Lartey, A., Okronipa, H., Ashorn, P., Zeilani, M., Peerson, J. M., Arimond, M., Vosti, S., Dewey, K. G.. "Lipid-based nutrient supplement increases the birth size of infants of primiparous women in Ghana ." The American Journal of Clinical Nutrition 101 , no. 4 (2015) : 835-46
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women
Flax, V. L., Bentley, M. E., Chasela, C. S., Kayira, D., Hudgens, M. G., Kacheche, K. Z., Chavula, C., Kourtis, A. P., Jamieson, D. J., van der Horst, C. M.. "Lipid-based nutrient supplements are feasible as a breastmilk replacement for HIV-exposed infants from 24 to 48 weeks of age ." The Journal of Nutrition 143 , no. 5 (2013) : 701-707
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women
Mridha, M. K., Matias, S. L., Chaparro, C. M., Paul, R. R., Hussain, S., Vosti, S. A., Harding, K. L., Cummins, J. R., Day, L. T., Saha, S. L., Peerson, J. M., Dewey, K. G.. "Lipid-based nutrient supplements for pregnant women reduce newborn stunting in a cluster-randomized controlled effectiveness trial in Bangladesh ." The American of Clinical Nutrition 103 , no. 1 (2016) : 236-49
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women
Hemsworth, J., Kumwenda, C., Arimond, M., Maleta, K., Phuka, J., Rehman, A. M., Vosti, S. A., Ashorn, U., Filteau, S., Dewey, K. G., Ashorn, P., Ferguson, E. L.. "Lipid-based nutrient supplements increase energy and macronutrient intakes from complementary food among Malawian infants ." The Journal of Nutrition 146 , no. 2 (2016) : 326-34
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Stunted
Dewey, K. G., Arimond, M.. "Lipid-based nutrient supplements: how can they combat child malnutrition? ." PLoS Medicine 9 , no. 9 (2012) : e1001314
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • SAM
  • MAM
Singh, A. S., Kang, G., Ramachandran, A., Sarkar, R., Peter, P., Bose, A.. "Locally made ready to use therapeutic food for treatment of malnutrition a randomized controlled trial ." Indian Pediatrics 47 , no. 8 (2010)
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Locally produced
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • MAM
Scherbaum, V., Purwestri, R. C., Stuetz, W., Inayati, D. A., Suryantan, J., Bloem, M. A., Biesalski, H. K.. "Locally produced cereal/nut/legume-based biscuits versus peanut/milk-based spread for treatment of moderately to mildly wasted children in daily programmes on Nias Island, Indonesia: an issue of acceptance and compliance? ." Asia Pacific Journal of Clinical Nutrition 24 , no. 1 (2015) : 152
Study Interventions
  • Animal-source protein
  • Behavior change communication (BCC)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
  • Other
Research Gaps
  • Acceptability
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • MAM
Huynh, D. T., Estorninos, E., Capeding, R. Z., Oliver, J. S., Low, Y. L., Rosales, F. J.. "Longitudinal growth and health outcomes in nutritionally at-risk children who received long-term nutritional intervention ." Journal of Human Nutrition and Dietetics 28 , no. 6 (2015) : 623-35
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Stunted
James, P. T., Van den Briel, N., Rozet, A., Israël, A. D., Fenn, B., Navarro-Colorado, C.. "Low‐dose RUTF protocol and improved service delivery lead to good programme outcomes in the treatment of uncomplicated SAM: a programme report from Myanmar ." Maternal & Child Nutrition 11 , no. 4 (2015) : 859-869
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • SAM
Flax, V. L., Thakwalakwa, C., Phuka, J., Ashorn, U., Cheung, Y. B., Maleta, K., Ashorn, P.. "Malawian mothers' attitudes towards the use of two supplementary foods for moderately malnourished children ." Appetite 53 , no. 2 (2009) : 195-202
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • MAM