Ongoing Trials

This page contains ongoing trials listed on one of five clinical trial registries searched by REFINE. These resources are tagged and searchable according to nutritional problem, study interventions, country, study type, and research gaps. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

In order to make Cambodia independent from importing a product for the treatment and prevention of malnutrition, UNICEF, DFPTQ Fisheries Administration and IRD have started a collaboration for the development of a range of products for the treatment and prevention of malnutrition. To reduce costs of the product, and to adapt the taste to local circumstances, the protein source of the usual RUTF (milk powder) has been changed to fish (Trey Riel).

Adequate nutrition during the first years of life is essential to reach full body and brain development potential. Children under the age of 5 in Central America and El Salvador suffer from micronutrient deficiencies. In El Salvador, ~ 20% of children under the age of 5 suffer from chronic undernutrition which is reflected in low length-for-their age Z-scores and anemia. This trial will examine the impact on health and growth in young children that will receive either a 21 micronutrient fortified cereal/legume mix manufactured in Guatemala or the current standard of nutritional care.

This study will be assessing the efficacy of micronutrient fortified biscuits on improving the nutrition status of children aged between 5 and 12 years in schools within the city of Lae, and on the rural fringe. Two schools will be selected from urban Lae, and two will be selected from rural Lae for the study, which is planned to commence in February 2017 and conclude in December 2017 for a full school year. This equates to approximately 200 school days.

The effect of a multiple micronutrient powder for point-of-use fortification of foods on the micronutrient status of underweight and overweight/obese primary school children in Vietnam – a randomised controlled trial

To determine if 6 months of legume-based complementary foods is effective in reducing or reversing EED and linear growth faltering in a cohort of Malawian children, aged 6-11 months to see if these improvements are correlated with specific changes in the enteric microbiome.


Cash transfer, aims to strengthen food security for vulnerable households by giving families enough purchasing power to consume an adequate and balanced diet, maintain a good standard of hygiene, access health services, and invest in their own means of food production in addition to their children's growth and development.

A convenience sample of 11 healthy children aged between 2 and 5 years will be recruited.The heights and weights will be checked to ensure that they are within the normal range of height and weight for their age and gender.  A food product which has been developed for children with severe acute malnutrition will be tested for taste acceptability among these children. Mothers with their children will be invited to the research institute. The food product that has been developed is packed in sachets in the form of an instant mix powder.

In Kenya children aged from six months to five years are usually given porridge in between meals and this usually continues when the children join nursery school. Protein and mineral deficiency is common in Kenyan children and insects have been shown to contain sufficient proteins and minerals when supplemented in complementary food. Cricket rearing is new in Kenya and farmed crickets could be used to improve the nutritional status and gut health of schoolchildren in Kenya.

Acute malnutrition in children under 5 is defined by being too thin for a given height and/or having the left arm circumference less than a given threshold (i.e. measuring how fat or thin the mid upper arm circumference (MUAC) is), and/or having swollen feet (malnutrition oedema). It affects 19 million children under five at any point in time, and can result in death if left untreated. Currently, children can receive treatment for uncomplicated acute malnutrition through outpatient treatment programs.