Ongoing Trials

This page contains ongoing trials listed on one of five clinical trial registries searched by REFINE. These resources are tagged and searchable according to nutritional problem, study interventions, country, study type, and research gaps. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

It has been shown that high energy nutritional supplements are very effective in treating malnutrition in developing countries. They promote weight gain and increase in energy intake, improves lipid profile and micronutrient status. This study aims to determine the effect of high-energy, nutritional supplements on appetite, energy intake, lipid profile and micronutrient status of moderately malnourished children.

Participants are randomly allocated to either receiving Ready to Use Supplementary Food (RUSF) (Acha Mum, provided by WFP) or to the Placebo group.

Malnutrition is still a problem in developing countries such as Indonesia. Undernutrition can cause damage to the mucus in the intestines (intestinal atrophy) causing problems in the intestines including not being able to absorbed nutrients, problems with the pancreas, and lactose intolerance. Intestinal atrophy in malnourished children can be rehabilitated with improving intestinal mucosal thickness in malnourished infants after nutritional rehabilitation. Supplementation of some nutritional components is essential in regenerating the intestinal mucosa.

Malnutrition is a public health problem in Kenya, with 26% of children under-five years of age stunted, and 26% of pre-school children, 26% of women of reproductive age and 42% of pregnant women being anaemic, respectively. Agriculture is the main source of income, food and nutrients for the majority of rural families in Sub-Saharan Africa including Kenya. Most farmers are smallholders and are vulnerable to poor nutrition.

The primary goal of this study is to prevent undernutrition and obesity in peri-urban areas of Colombia. This study is designed to evaluate the impact of promoting adequate feeding practices and the use of SQ-LNS (Small Quantity Lipid-Based Nutrient Supplements) on the nutritional status of infants and young children. The study will be conducted in peri-urban areas of Pasto, Colombia in conjunction with Fundación Saldarriaga Concha and the Colombian Ministry of Health and Social Protection.

This is a randomized, double-blind, community-based efficacy trial of different doses, forms, and frequencies of zinc supplementation for the prevention of diarrhea and promotion of linear growth among children 9-11 months of age in Dhaka, Bangladesh.

The primary goal of the study is to prevent undernutrition and obesity in children under two years old in rural areas of Guatemala. This study is designed to evaluate whether the proposed treatment reduces the prevalence of overweight, underweight and low height-for-age indicators in the rural environment of Baja Verapaz. This study design has been developed in conjunction with colleagues from Fundazúcar, a local foundation in Guatemala.

Malnutrition is a public health problem, with long-lasting physiological consequences and increased risk of morbidity and mortality. It can be recognized as one of the key obstacles in national development, due to its influence on individual productivity, school performance and physical work capacity. Malnutrition is a hidden crisis in Pakistan, with rates increasing during the last decade. High prevalence of food insecurity, illiteracy, lack of nutritional knowledge, poor hygiene status, and under recognized role of nutrition are some of the possible causes.

This is a prospective, randomised, double-blinded, controlled clinical effectiveness trial of two supplementary foods in the treatment of MAM. The setting will be 21 rural sites in southern Malawi. The participants will be 1800 children 6-59 months old with MAM, defined as mid-upper arm circumference (MUAC) ≥ 11.5 cm and < 12.5 cm and/or a weight-for-height Z-score (WHZ) between -2 and -3 without bipedal edema. Children will receive approximately 75 kcal/kg/d (314 kJ/kg/d) of one of two RUSFs in two-week rations for outpatient therapy of MAM.

Severe acute malnutrition is a serious illness and a common problem. In malnutrition, the gut becomes damaged and does not function properly. This means a lot of the food is lost in the stool, sometimes as diarrhoea, and not enough food gets into the body. Healthy bacteria live in the gut and do not cause any illness, but the types of bacteria may change in malnutrition to ones that can cause serious infections. Good bacteria use food that the body cannot digest (fibre/roughage) and turn it into helpful products.