Effects of Oral Nutrition Supplements in Children With Disease Associated Underweight (MIntS)

Primary Investigator

  • Dr. Michael Chourdakis, Aristotle University Of Thessaloniki

Study Period

December 2015 - May 2018

Study Description

Brief Summary:

The purpose of this study is to test whether the provision of ONS to malnourished children across Europe, in addition to standard counselling, will improve weight gain and other outcomes.

The hypothesis to be tested is:

Supplementation with ONS in malnourished paediatric patients will lead to increased WFH gain, as well as less malnutrition related complications (e.g. infections).

Primary outcome: The change in BMI z-score over the intervention period of 3 months

Secondary outcomes: The change in WFH-weight for height (z-scores) over the intervention period of 3 months

Study Arms

  • Experimental: Oral Nutritional Supplement (ONS) Diet consultation for the child/family + ONS, Dietary Supplement: The ONS provided to the children intervention group will be a ready to drink age adapted oral nutrition supplement providing 1,5 kcal/ml The
  • No Intervention: No Oran Nutritional Supplement (ONS) Diet consultation for the child/family

Primary Outcomes

  • BMI z-score [ Time Frame: 3 months ]; The change in BMI z-score over the intervention period of 3 months

Study Intervention

  • Standard Fortified Food Blends

Research Gaps

  • Effectiveness

    How well do different food compositions and interventions prevent or treat undernutrition, when implemented "on the ground"?

Study Population

224