The impact of legumes vs corn-soy flour on environmental enteric dysfunction in rural Malawian children 1-3 year olds

Primary Investigator

  • Mark Manary

Study Period

August 2015 - December 2016

Study Description

To determine if 12 months of legume-based complementary foods is effective in reducing or reversing EED and linear growth faltering in a cohort of Malawian children, aged 12-35 months to see if these improvements are correlated with specific changes in the enteric microbiome. 

Study Arms

  • Experimental: Cowpeas Cowpea supplementary food that will be approximately 15% of the calculated total daily intake. Children will receive the food for 12 months. Intervention: Dietary Supplement: cowpeas complementary food
  • Experimental: Common bean Common bean supplementary food that will be approximately 15% of the calculated total daily intake. Children will receive the food for 12 months. Intervention: Dietary Supplement: common bean complementary food
  • Active Comparator: Corn Soy Flour Corn flour with 10% soy supplementary food that will be approximately 15% of the calculated total daily intake. Children will receive the food for 12 months. Intervention: Dietary Supplement: corn-soy flour

Primary Outcomes

  • Dual Sugar Absorption Test

Study Interventions

  • Standard Fortified Food Blends
  • Plant-source protein
  • Environmental enteric dysfunction (EED)
  • Locally produced

Research Gaps

  • Composition

    Which ingredients offer the best prevention or treatment for undernutrition?

  • Effectiveness

    How well do different food compositions and interventions prevent or treat undernutrition, when implemented "on the ground"?

  • Innovation

    What novel food-based products and programming methods effectively prevent and treat undernutrition?

Study Population

300