Integrated treatment protocol for acute malnutrition: A non inferiority trial in Burkina Faso (MUAC-Only)

Primary Investigators

  • Renaud Becquet
  • Susan Shepherd

Study Period

January 2017 - April 2018

Study Description

MUAC only is a non-inferiority trial with external control carried out between January 2017 and December 2017 in the Yako district (northern region), Burkina Faso.

The objective of this study is to evaluate an integrated protocol for acute malnourished children without medical complication. The hypotheses of the integrated protocol include :

  1. A global treatment of acute malnutrition (moderate and severe) with a single treatment (RUTF) would improve the functioning of the program through early identification of acutely malnourished children, while achieving a better coverage and using a single supply chain.
  2. A gradual reduction of RUTF dosage according to a child's MUAC status could significantly increase the number of children on treatment without increasing overall RUTF quantity while maintaining similar recovery rates.

Study Arm

  • Single treatment of RUTF for children w/ MAM and SAM; gradual dose reduction according to child's MUAC and weight during treatment. MUAC split into 3 categories: MUAC<115 mm: 175 kcal/kg/day; 115

Primary Outcomes

  • Recovery rate

Study Intervention

  • Standard Lipid-Based Nutrient Supplements (LNS)

Research Gaps

  • Effectiveness

    How well do different food compositions and interventions prevent or treat undernutrition, when implemented "on the ground"?

  • Innovation

    What novel food-based products and programming methods effectively prevent and treat undernutrition?

Study Population