Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 7 of 7 Results
Nancy F. Krebs, Michael Hambidge, Jamie L. Westcott, Ana L. Garcés, Lester Figueroa, Antoinette K. Tsefu, Adrien L. Lokangaka. "." The Journal of Pediatrics (2020)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Deanna K Olney, Jef Leroy, Lilia Bliznashka, and Marie T Ruel. " Background Food-assisted maternal and child health and nutrition (FA-MCHN) programs may foster child growth during the first 1000 d (pregnancy and the first 2 y of a child's life), but evidence is scant. Objective We evaluated the impact of an FA-MCHN program, PROCOMIDA, on linear growth (stunting [length-for-age z score (LAZ) < –2] and length-for-age difference [LAD]) among children aged 1–24 mo. PROCOMIDA was implemented in Guatemala by Mercy Corps and was available to beneficiaries throughout the first 1000 d. Methods We used a longitudinal, cluster-randomized controlled trial with groups varying in family ration sizes [full (FFR), reduced (RFR), and none (NFR)] and individual ration types provided to mothers (pregnancy to 6 mo postpartum) and children (6–24 mo of age) [corn-soy blend (CSB), lipid-based nutrient supplement (LNS), micronutrient powder (MNP)]: 1) FFR + CSB (n = 576); 2) RFR + CSB (n = 575); 3) NFR + CSB (n = 542); 4) FFR + LNS (n = 550); 5) FFR + MNP (n = 587); 6) control (n = 574). Program impacts compared with control, and differential impacts between groups varying family ration size or individual ration type, were assessed through the use of linear mixed-effects models and post hoc simple effect tests (significant if P < 0.05). Results PROCOMIDA significantly reduced stunting at age 1 mo in FFR + CSB, RFR + CSB, and FFR + MNP groups compared with control [5.05, 4.06, and 3.82 percentage points (pp), respectively]. Stunting impact increased by age 24 mo in FFR + CSB and FFR + MNP relative to control (impact = 11.1 and 6.5 pp at age 24 mo, respectively). For CSB recipients, the FFR compared with RFR or NFR significantly reduced stunting (6.47–9.68 pp). CSB reduced stunting significantly more than LNS at age 24 mo (8.12 pp). Conclusions FA-MCHN programs can reduce stunting during the first 1000 d, even in relatively energy/food-secure populations. Large family rations with individual rations of CSB or MNP were most effective. The widening of impact as children age highlights the importance of intervening throughout the full first 1000 d. ." The Journal of Nutrition 148 , no. 9 (2018) : 1493–1505
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Boris Martinez, Meghan Farley Webb, Ana Gonzalez, Kate Douglas, Maria del Pilar Grazioso, Peter Rohloff. "." BMJ Paediatrics Open 2 , no. 1 (2018)
Study Interventions
  • Other
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Martorell, R.. "Improved nutrition in the first 1000 days and adult human capital and health ." American Journal of Human Biology 29 , no. 2 (2017)
Study Interventions
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Matias, S. L., Chaparro, C. M., Perez-Exposito, A. B., Peerson, J. M., Dewey, K. G.. "Acceptability of a lipid-based nutrient supplement among Guatemalan infants and young children ." (2011)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Lakkam, M., Wager, S., Wise, P. H., Wein, L. M.. "Quantifying and exploiting the age dependence in the effect of supplementary food for child undernutrition ." PloS One 9 , no. 6 (2014) : e99632
Study Interventions
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Caulfield, L. E., Huffman, S. L., Piwoz, E. G.. "." Food and Nutrition Bulletin 2 , no. 2 (1999) : 183-200
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
  • Efficacy
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight