Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 69 Results
Theresa Banda, Khataza Chawanda, Wakako Tsuchida, Slyvester Kathumba. "." Food and Nutrition Bulletin 42 , no. 1 (2021) : 91-103
Study Interventions
  • Plant-source protein
  • Experimental Lipid Based Nutrients
Research Gaps
  • Composition
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Kristen M Hurley, John Phuka, Yunhee Kang, Julie Ruel-Bergeron, Audrey J Buckland, Maithilee Mitra, Lee Wu, Rolf D W Klemm, Keith P West, Jr., Parul Christian. "." The American Journal of Clinical Nutrition (2021)
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Parul Christian, Kristen M Hurley, John Phuka, Yunhee Kang, Julie Ruel-Bergeron, Audrey J Buckland, Maithilee Mitra, Lee Wu, Rolf Klemm, Keith P West, Jr. "." The Journal of Nutrition (2020)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Rebecca Roediger, Hans-Henrik Stein, Meghan Callaghan-Gillespie , Jeffrey Kahn Blackman, Kristin Kohlmann, Kenneth Maleta, Mark Manary. "." Maternal & Child Nutrition , no. e13019 (2020)
Study Interventions
  • Animal-source protein
  • Standard Fortified Food Blends
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Rosalie H. Bartels, Emmanuel Chimwezi, Victoria Watson, Leilei Pei, Isabel Potani, Benjamin Allubha, Kate Chidzalo, Duolao Wang, Queen Dube, Macpherson Mallewa, Angela Allen, Robert H. J. Bandsma, Wieger P. Voskuijl and Stephen J. Allen . "." Scientific Reports, Nature Publishing 9 , no. 1 (2019)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Minyanga Nkhoma, Per Ashorn, Ulla Ashorn, Kathryn G. Dewey, Austrida Gondwe, and Kenneth Maleta . "." PLoS One 14 , no. 5 (2019)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Peter Akomo, Paluku Bahwere, Hitoshi Murakami, Chrissy Banda, Elizabeth Maganga, Sylvester Kathumba, Kate Sadler, Steve Collins . "." BMC Public Health 19 , no. 1 (2019)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
M Isabel Ordiz, Richard D Semba, Ruin Moaddel, Ulrike Rolle-Kampczyk, Martin von Bergen, Gunda Herberth, Mohammed Khadeer, Stefan Röder, Mark J Manary. "." Current Developments in Nutrition 3 , no. 10 (2019)
Study Interventions
  • Standard Fortified Food Blends
  • Plant-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Mangani C, Maleta K, Phuka J, Cheung YB, Thakwalakwa C, Dewey K, Manary M, Puumalainen T, Ashorn P.. "." Maternal & Child Nutrition 11 , no. S4 (2015) : 132-143
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Cambria M. Glosz, Andrew A. Schaffner, Scott K. Reaves, Mark J. Manary, and Peggy C. Papathakis. "." Nutrients 10 , no. 7 (2018) : 879
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
  • Treatment of Severe Acute Malnutrition
Wataru Sato, Chie Furuta, Keiko Matsunaga, Paluku Bahwere, Steve Collins, Kate Sadler, Peter Akomo, Chrissy Banda, Elizabeth Maganga, Sylvester Kathumba, Hitoshi Murakami. "." PLoS One 13 , no. 8 (2018)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Robert H. J. Bandsma , Wieger Voskuijl, Emmanuel Chimwezi, Greg Fegan, André Briend, Johnstone Thitiri, Moses Ngari, Laura Mwalekwa, Victor Bandika, Rehema Ali, Fauzat Hamid, Betty Owor, Neema Mturi, James A. Berkley. "     ." PLoS Medicine 2 , no. 16 (2019)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Agapova, S. E., Stephenson, K. B., Divala, O., Kaimila, Y., Maleta K. M., Thakwalakwa, C., Ordiz, M. I., Trehan, I., Manary, M. J.. "." 148 , no. 2 (2018) : 267–274
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Kevin B Stephenson, Sophia E Agapova, Oscar Divala, Yankho Kaimila, Kenneth M Maleta, Chrissie Thakwalakwa, M Isabel Ordiz, Indi Trehan, Mark J Manary. "." American Journal of Clinical Nutrition 106 , no. 6 (2017) : 1500-1507
Study Interventions
  • Standard Fortified Food Blends
  • Environmental enteric dysfunction (EED)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Heather C Stobaugh, Lucy B Bollinger, Sara E Adams, Audrey H Crocker, Jennifer B Grise, Julie A Kennedy, Chrissie Thakwalakwa, Kenneth M Maleta, Dennis J Dietzen , Mark J Manary, Indi Trehan. "." The American Journal of Clinical Nutrition 106 , no. 2 (2017) : 657-666
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Wilner, L., Suri, D. J., Langlois, B. K., Walton, S. M., Rogers, B. L.. "." Journal of Health, Population and Nutrition 36 , no. 34 (2017)
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Lagrone, L., Cole, S., Schondelmeyer, A., Maleta, K., Manary, M. J.. "." Annals of Tropical Paediatrics 30 , no. 2 (2010)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
Research Gaps
  • Cost
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Lin, C. A., Manary, M. J., Maleta, K., Briend, A., Ashorn, P.. "An energy-dense complementary food is associated with a modest increase in weight gain when compared with a fortified porridge in Malawian children aged 6–18 months ." Journal of Nutrition 138 (2008) : 593-598
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Callaghan-Gillespie, M., Schaffner, A. A., Garcia, P., Fry, J., Eckert, R. , Malek, S., Trehan, I., Thakwalakwa, C., Maleta, K. M., Manary, M. J., Papathakis, P. C.. "Trial of ready-to-use supplemental food and corn-soy blend in pregnant Malawian women with moderate malnutrition: a randomized controlled clinical trial ." American Journal of Clinical Nutrition 106 , no. 4 (2017) : 1062-1069
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Bahwere, P., Akomo, P., Mwale, M., Murakami, H., Banda, C., Kathumba, S., Banda, C., Jere, S., Sadler, K., Collins, S.. "." American Journal of Clinical Nutrition (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Manary, M., Callaghan, M., Wegner, D., Papathakis, P.. "Randomized controlled trial of the impact of treating moderately malnourished women in pregnancy ." (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Ashorn, P., Poelman, B., Dewey, K. G., Maleta, K., Klein, N., Rogerson, S., Meshnick, S. R., The LNS-RTI Study Team. "The impact of dietary supplementation with lipid-based nutrient supplements on maternal health and pregnancy outcomes in rural Malawi ." (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Kodish, S. R., Aburto, N. J., Hambayi, M. N., Dibari, F., Gittelsohn, J.. "Patterns and determinants of small-quantity LNS utilization in rural Malawi and Mozambique: considerations for interventions with specialized nutritious foods ." Maternal & Child Nutrition 13 , no. 1 (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Versloot, C. J., Voskuijl, W., van Vliet, S. J., van den Heuvel, M., Carter, J. C., Phiri, A., Kerac, M., Heikens, G. T., van Rheenen, P. F., Bandsma, R. H. J.. " Effectiveness of three commonly used transition phase diets in the inpatient management of children with severe acute malnutrition: a pilot randomized controlled trial in Malawi ." BMC Pediatrics 17 , no. 112 (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Wang, A. Z., Shulman, R. J., Crocker, A. H., Thakwalakwa, C., Maleta, K. M., Devaraj, S., Manary, M., Trehan, I.. "A combined intervention of zinc, multiple micronutrients, and Albendazole does not ameliorate environmental enteric dysfunction or stunting in rural Malawian children in a double-blind randomized controlled trial ." The Journal of Nutrition 147 , no. 1 (2017) : 97-103
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight