Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 15 of 15 Results
Caroline Marquer, Céline Langendorf, Lynda Christelle Woi-Messe, Fatou Berthe, Eric-Alain Ategbo, Santiago Rodas-Moya, Saskia dePee,, and Rebecca F. Grais. "." BMC Nutrition 6 , no. 1 (2020) : 1-8
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Sibson VL, Grijalva-Eternod CS, Noura G, Lewis J, Kladstrup K, Haghparast-Bidgoli H, Skordis-Worrall, Colbourn T, Morrison J, Seal AJ. "." Maternal & Child Nutrition 14 , no. 4 (2018)
Study Interventions
  • Cash transfer
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Jessica Bliss, Kate Golden, Leila Bourahla, Rebecca Stoltzfus, David Pelletier. "." Journal of Global Health 8 , no. 1 (2018)
Study Interventions
  • Cash transfer
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Isanka, S., Roederer, T., Djibo, A., Luquero, F. J., Nombela, N., Guerin, P. J., Grais, R. F.. "Reducing wasting in young children with preventive supplementation: a cohort study in Niger ." Pediatrics 126 , no. 2 (2010) : e442-450
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Isanka, S., Kodish, S. R., Berthe, F., Alley, I., Nackers, F., Hanson, K. E., Grais, R. F.. "Outpatient treatment of severe acute malnutrition: response to treatment with a reduced schedule of therapeutic food distribution ." The American Journal of Clinical Nutrition (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Isanka, S., Menzies, N. A., Sayyad, J., Ayoola, M., Grais, R. F., Doyon, S.. "Cost analysis of the treatment of severe acute malnutrition in West Africa ." Maternal & Child Nutrition (2016)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Animal-source protein
Research Gaps
  • Cost
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Isanaka, S., Langendorf, C., Berthé, F., Gnegne, S., Li, N., Ousmane, N., Harouna, S., Hassane, H., Schaefer, M., Adehossi, E., Grais, R. F.. "Routine amoxicillin for uncomplicated severe acute malnutrition in children ." The New England Journal of Medicine 374 (2016) : 444-453
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Other
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Sayyad-Neerkorn, J., Langendorf, C., Roederer, T., Doyon, S., Mamaty, A., Woi-Messe, L., Manzo, M. L., Harouna, S., de Pee, S., Grais, R. F.. "Preventive effects of long-term supplementation with 2 nutritious food supplements in young children in Niger     ." The Journal of Nutrition 145 , no. 11 (2015) : 2596-2603
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Kerac, M., Seal, A.. "Preventing acute malnutrition in young children: Improving the evidence for current and future practice ." PLoS Medicine 11 , no. 9 (2014) : e1001715
Study Interventions
  • Cash transfer
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Cohuet, S., Marquer, C., Shepherd, S., Captier, V., Langendorf, C., Ale, F., Phelan, K., Manzo, M. L., Grais, R. F.. "Intra-household use and acceptability of Ready-to-Use-Supplementary-Foods distributed in Niger between July and December 2010 ." Appetite 59 , no. 3 (2012) : 698-705
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Tripp, K., Perrine, C. G., de Campos, P., Knieriemen, M., Hartz, R., Jefferds, M. E., Kupka, R.. "Formative research for the development of a market‐based home fortification programme for young children in Niger ." Maternal & Child Nutrition 7 , no. Supplement 3 (2011) : 82-95
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
  • Treatment of Severe Acute Malnutrition
Prudhon, C., Langendorf, C., Roederer, T., Doyon, S., Mamaty, A., Woi-Messe, L., Manzo, M. L., de Pee, S., Grais, R. F.. "Effect of ready-to-use foods for preventing child undernutrition in Niger: analysis of a prospective intervention study over 15 months of follow-up ." Maternal & Child Nutrition 13 , no. 1 (2016)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Cash transfer
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Isanaka, S., Nombela, N.ohelly, Djibo, A., Poupard, M., Van Beckhoven, D., Gaboulaud, V., Guerin, P. J., Grais, R. F.. "Effect of preventive supplementation with ready-to-use therapeutic food on the nutritional status, mortality, and morbidity of children aged 6 to 60 months in Niger: a cluster randomized trial. ." Journal of the American Medical Association 301 , no. 3 (2009) : 277-85
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Grellety, E., Shepherd, S., Roederer, T., Manzo, M. L., Doyon, S., Ategbo, E., Grais, R. F.. "Effect of mass supplementation with ready-to-use supplementary food during an anticipated nutritional emergency ." PloS One 7 , no. 9 (2012) : e44549
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Langendorf, C., Roederer, T., de Pee, S., Brown, D., Doyon, S., Mamaty, A., Touré, L. W., Manzo, M. L., Grais, R. F.. "Preventing acute malnutrition among young children in crises: A prospective intervention study in Niger ." PLOS Medicine (2012)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Other
  • Cash transfer
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight