Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 32 Results
Victor Nikièma, Nadia F Fogny, Cécile Salpéteur, Carl Lachat, Suvi T Kangas. "." Maternal & Child Nutrition (2021) : e13220
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Use
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Brenda de Kok, Katie Moore, Leslie Jones, Katrien Vanslambrouck, Laeticia Celine Toe, Moctar Ouédraogo, Rasmané Ganaba, Saskia de Pee, Juliet Bedford, Carl Lachat, Patrick Kolsteren, Sheila Isanaka. "." Maternal & Child Nutrition (2021) : e13134
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Experimental Lipid Based Nutrients
Research Gaps
  • Acceptability
  • Efficacy
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Dieynaba S. N'Diaye, Bibata Wassonguema, Victor Nikièma, Suvi T. Kangas, Cécile Salpéteur. "." Maternal & Child Nutrition (2021) : e13118
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Cost
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Victor Nikièma, Suvi T Kangas, Cécile Salpéteur, Abdoulaye Ouédraogo, Carl Lachat, Nestor H I Bassolé, Nadia F Fogny. "." The Journal of Nutrition (2021) : nxaa393
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Katrien Vanslambrouck, Brenda de Kok, Laeticia Celine Toe , Nathalie De Cock, Moctar Ouedraogo, Trenton Dailey-Chwalibóg, Giles Hanley-Cook, Rasmané Ganaba, Carl Lachat, Lieven Huybregts, Patrick Kolsteren. "." BMJ Open , no. 11 (2021) : e038393
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Efficacy
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Mette F. Olsen, Ann-Sophie Iuel-Brockdorff, Charles W. Yaméogo, Bernardette Cichon, Christian Fabiansen, Suzanne Filteau, Kevin Phelan, Albertine Ouédraogo, Kim F. Michaelsen, Melissa Gladstone, Per Ashorn, André Briend, Christian Ritz, Henrik Friis, Vibeke B. Christ. "." PLoS medicine 17 , no. 12 (2020) : e1003442
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Animal-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Ilana R. Cliffer, William A. Masters, Beatrice L. Rogers. "." Maternal & Child Nutrition , no. e13089 (2020)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Stark, Heather, Anteneh Omer, Aïssata Wereme N'Diaye, Amanda C. Sapp, Emily V. Moore, Sarah L. McKune. "." Maternal & Child Nutrition (2020) : e13069
Study Interventions
  • Behavior change communication (BCC)
  • Locally produced
  • Animal-source protein
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Maren J. H. Rytter, Bernardette Cichon, Christian Fabiansen, Charles W. Yameogo, Sylvain Z. Windinmi, Kim F. Michaelsen, Suzanne Filteau, Dorthe L. Jeppesen, Henrik Friis, André Briend, Vibeke B. Christensen . "." Pediatric Research (2020) : 1-10
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Ye Shen, Ilana R. Cliffer, Devika J. Suri, Breanne K. Langlois, Stephen A. Vosti, Patrick Webb, Beatrice L. Rogers. "." Nutrition Journal 19 , no. 1 (2020) : 1-18
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Cost
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Ilana R Cliffer, Laetitia Nikiema, Breanne K Langlois, Augustin N Zeba, Ye Shen, Hermann B Lanou, Devika J Suri, Franck Garanet, Kenneth Chui, Stephen Vosti, Shelley Walton, Irwin Rosenberg, Patrick Webb, Beatrice L Rogers. "." Current Developments in Nutrition 4 , no. 2 (2020)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Cost
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Breanne K Langlois, Ilana R Cliffer, Laetitia Nikiema, Devika J Suri, Franck Garanet, Ye Shen, Augustin N Zeba, Shelley M Walton, Hermann B Lanou, Patrick Webb, and Beatrice L Rogers. "." Current Developments in Nutrition 4 , no. 2 (2020)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Elodie Becquey, Lieven Huybregts, Amanda Zongrone, Agnes Le Port, Jef L. Leroy, Rahul Rawat, Mariama Touré, Marie T. Ruel. "." PLOS Medicine 16 , no. 8 (2019)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Christian Fabiansen, Kevin PQ Phelan, Bernardette Cichon, Christian Ritz, André Briend, Kim F Michaelsen, Henrik Friis, Susan Shepherd. "." American Journal of Clinical Nutrition 103 , no. 2 (2016) : 415-421
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Christian Fabiansen, Charles W. Yaméogo, Ann-Sophie Iuel-Brockdorf, Bernardette Cichon, Maren J. H. Rytter, Anura Kurpad, Jonathan C. Wells, Christian Ritz, Per Ashorn, Suzanne Filteau, André Briend, Susan Shepherd, Vibeke B. Christensen, Kim F. Michaelsen, Henrik Friis. "." PLoS Medicine 14 , no. 9 (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Kampstra, N. A., Van Hoan, N., Koenders, D. J. P. C., Schoop, R., Broersen, C. B., Mouquet-Rivier, C., Traore, T., Bruins, M. J., de Pee, S.. "Energy and nutrient intake increased by 47–67% when amylase was added to fortified blended foods—a study among 12- to 35-month-old Burkinabe children ." Maternal & Child Nutrition (2017)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Houngbe, F., Tonguet-Papucci, A., Altare, C., Ait-Aissa, M., Huneau, J-F., Huybregts, L., Kolsteren, P.. "Unconditional cash transfers do not prevent children's undernutrition in the Moderate Acute Malnutrition Out (MAM'Out) cluster-randomized controlled trial in rural Burkina Faso ." The American Society for Nutrition (2017)
Study Interventions
  • Cash transfer
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Olney, D. K., Bliznashka, L., Becquey, E., Birba, O., Ruel, M.. "Adding a water, sanitation and hygiene intervention and a lipid-based nutrient supplement to an integrated agriculture and nutrition program improved the nutritional status of young Burkinabé children ." The FASEB Journal 31 , no. 1 (2017) : Supplement 455.1
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Iuel-Brockdorf, A., Ouedraogo, A., Ritz, C., Draebel, T. A., Ashorn, P., Filteau, S., Michaelsen, K. F.. "Feeding behaviors during home-based treatment of moderate acute malnutrition using corn-soy blends or lipid-based nutrient supplements ." Maternal & Child Nutrition (2016)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Arimond, M., Zeilani, M., Jungjohann, S., Brown, K. H., Ashorn, P., Allen, L. H., Dewey, K. G.. "Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS) Project ." Maternal & Child Nutrition 11 , no. S4 (2015) : 31-61
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Abbeddou, S., Hess, S. Y., Yakes Jimenez, E., Somé, J. W., Vosti, S. A., Guissou, R. M., Ouedragogo, J. B., Brown, K. H.. "Comparison of methods to assess adherence to small-quantity lipid-based nutrient supplements (SQ-LNS) and dispersible tablets among young Burkinabé children participating in a community-based intervention trial ." Maternal & Child Nutrition 11 , no. S4 (2015) : 90-104
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Nikièma, L., Huybregts, L., Kolsteren, P., Lanou, H., Tiendrebeogo, S., Bouckaert, K., Kouanda, S., Sondo, B., Roberfroid, D.. "Treating moderate acute malnutrition in first-line health services: an effectiveness cluster-randomized trial in Burkina Faso ." The American Journal of Clinical Nutrition 100 , no. 1 (2014) : 241-9
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Behavior change communication (BCC)
  • Locally produced
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Tonguet-Papucci, A., Huybregts, L., Aissa, M. A.. "The MAM'Out project: a randomized controlled trial to assess multiannual and seasonal cash transfers for the prevention of acute malnutrition in children ." BMC Public Health (2015)
Study Interventions
  • Cash transfer
Research Gaps
  • Cost
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Hess, S. Y., Abbeddou, S., Jimenez, E. Y., Somé, J. W., Vosti, Stephen A, Ouédraogo, Z. P., Guissou, R. M., Ouédraogo, J., Brown, K. H.. "Small-quantity lipid-based nutrient supplements, regardless of their zinc content, increase growth and reduce the prevalence of stunting and wasting in young burkinabe children: a cluster-randomized trial ." PloS One 10 , no. 3 (2015) : e0122242
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Toe, L. C., Bouckaert, K. P., De Beuf, K., Roberfroid, D., Meda, N., Thas, O., Van Camp, J,, Kolsteren, P. W., Huybregts, L. F.. "Seasonality modifies the effect of a lipid-based nutrient supplement for pregnant rural women on birth length ." The Journal of Nutrition 145 , no. 3 (2015) : 634-639
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight