Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 51 Results
Marius Affonfere, Flora Josiane Chadare, Finagnon Toyi Kévin Fassinou, Elise F. Talsma, Anita R. Linnemann, Paulin Azokpota. "." Food Science & Nutrition (2021)
Study Interventions
  • Micronutrient powders (MNP)
  • Locally produced
Research Gaps
  • Acceptability
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Brenda de Kok, Katie Moore, Leslie Jones, Katrien Vanslambrouck, Laeticia Celine Toe, Moctar Ouédraogo, Rasmané Ganaba, Saskia de Pee, Juliet Bedford, Carl Lachat, Patrick Kolsteren, Sheila Isanaka. "." Maternal & Child Nutrition (2021) : e13134
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Experimental Lipid Based Nutrients
Research Gaps
  • Acceptability
  • Efficacy
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Harriet Okronipa, Amado D Quezada-Sánchez, Susan L Johnson, Cloe Rawlinson, Selene Pacheco-Miranda, Mónica Venosa López, Anabelle Bonvecchio Arenas, Wendy Gonzalez Navarrete. "." Nutrients 12 , no. 10 (2020) : 3069
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Stark, Heather, Anteneh Omer, Aïssata Wereme N'Diaye, Amanda C. Sapp, Emily V. Moore, Sarah L. McKune. "." Maternal & Child Nutrition (2020) : e13069
Study Interventions
  • Behavior change communication (BCC)
  • Locally produced
  • Animal-source protein
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Shehla Zaidi , Jai K. Das, Gul Nawaz Khan, Rabia Najmi, Mashal Murad Shah, Sajid B. Soofi. "." BMC Public Health 20 , no. 1 (2020) : 1046
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Micronutrient powders (MNP)
Research Gaps
  • Acceptability
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Caroline Marquer, Céline Langendorf, Lynda Christelle Woi-Messe, Fatou Berthe, Eric-Alain Ategbo, Santiago Rodas-Moya, Saskia dePee,, and Rebecca F. Grais. "." BMC Nutrition 6 , no. 1 (2020) : 1-8
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Catherine Chunda-Liyoka, Mwansa Ketty Lubeya, Mercy Imakando, Sophia Kisling, Sonoor Majid, Mary S. Willis, Charles Wood, Chipepo Kankasa , Concetta C. DiRusso. "." BMC Pregnancy and Childbirth 20 , no. 1 (2020) : 93
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Elizabeth T Rogawski McQuade, James A Platts-Mills, Jean Gratz, Jixian Zhang, Lawrence H Moulton, Kuda Mutasa, Florence D Majo, Naume Tavengwa, Robert Ntozini, Andrew J Prendergast, Jean H Humphrey, and Jie Liu, Eric R Houpt. "." Journal of Infectious Diseases (2019) : jiz179
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Environmental enteric dysfunction (EED)
  • Behavior change communication (BCC)
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Cornelius M Smuts, Tonderayi M Matsungo, Linda Malan, Herculina S Kruger, Marinel Rothman, Jane D Kvalsvig, Namukolo Covic, Karen Joosten, Saskia J M Osendarp, Maaike J Bruins, Leon G J Frenken, Carl J Lombard, Mieke Faber. "." The American Journal of Clinical Nutrition 109 , no. 1 (2019) : 55-68
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Md. Iqbal Hossain, Sayeeda Huq, M. Munirul Islam, Tahmeed Ahmed.. "." European Journal of Nutrition (2019)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Sigh S, Roos N, Sok D, Borg B, Chamnan C, Laillou A, Dijkhuizen MA, Wieringa FT.. "." Food and Nutrition Bulletin 39 , no. 8 (2018)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Bindi Borg, Seema Mihrshahi, Mark Griffin, Daream Sok, Chamnan Chhoun, Arnaud Laillou, Frank T. Wieringa. "." Maternal & Child Nutrition 15 , no. 3 (2019)
Study Interventions
  • Standard Fortified Food Blends
  • Locally produced
Research Gaps
  • Acceptability
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Kwaku Tano-Debrah, Firibu Kwesi Saalia, Shibani Ghosh, Masashi Hara. "." Food And Nutrition Bulletin (2019)
Study Interventions
  • Standard Fortified Food Blends
  • Locally produced
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Dube, B., Rongsen, T., Mazumder, S., Taneja, S., Rafiqui, F., Bhandari, N., Bhan, M. K.. "Comparison of ready-to-use therapeutic food with cereal legume-based Khichri among malnourished children ." Indian Pediatrics 46 (2009) : 383-388
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Locally produced
Research Gaps
  • Acceptability
  • Composition
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Adams, A. M., Ahmed, R., Mahbub Latif, A. H. M., Rasheed, S., Das, S. K., Hasib, E., Farzana, F. D., Ferdous, F., Ahmed, S., Faruque, A. S. G.. "Impact of fortified biscuits on micronutrient deficiencies among primary school children in Bangladesh ." PLoS One (2017)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Stevens, B., Watt, K., Brimblecombe, J., Clough, A., Judd, J.. "Development of a locally produced, balanced protein-energy food-based supplement and its acceptance by undernourished pregnant women in Northern Bangladesh ." Journal of Hunger & Environmental Nutrition (2016) : 100-115
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
Research Gaps
  • Acceptability
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Lanyero, B., Namusoke, H., Nabukeera-Barungi, N., Grenov, B., Mupere, E., Michaelsen, K. F., Molgaard, C., Christensen, V. B., Friis, H., Briend, A.. "Transition from F-75 to ready-to-use therapeutic food in children with severe acute malnutrition, an observational study in Uganda ." Nutrition Journal 16 , no. 1 (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Kampstra, N. A., Van Hoan, N., Koenders, D. J. P. C., Schoop, R., Broersen, C. B., Mouquet-Rivier, C., Traore, T., Bruins, M. J., de Pee, S.. "Energy and nutrient intake increased by 47–67% when amylase was added to fortified blended foods—a study among 12- to 35-month-old Burkinabe children ." Maternal & Child Nutrition (2017)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Sulistiyono, P., Herawati, D. M. D., Arya, I. F. D.. "Rebon shrimp powder addition influence to nutritional values, organoleptic properties and acceptance of supplementary food by children aged 4-5 years old ." Kesmas: National Public Health Journal 11 , no. 4 (2017) : 168-172
Study Interventions
  • Locally produced
  • Animal-source protein
Research Gaps
  • Acceptability
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Thapa, B. R., Goyal, P., Menon, J., Sharma, A.. "Acceptability and efficacy of locally produced ready-to-use therapeutic food nutreal in the management of severe acute malnutrition in comparison with defined food: A randomized control trial ." Food and Nutrition Bulletin 38 , no. 1 (2017) : 18-26
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
Research Gaps
  • Acceptability
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Weber, J. M., Ryan, K. N., Tandon, R., Mathur, M., Girma, T., Steiner-Asiedu, M., Saalia, F., Zaidi, S., Soofi, S., Okos, M., Vosti, S. A.. "Acceptability of locally produced ready-to-use therapeutic foods in Ethiopia, Ghana, Pakistan and India ." Maternal & Child Nutrition 13 , no. 2 (2017) : e12250
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
Research Gaps
  • Acceptability
  • Cost
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Matias, S. L., Chaparro, C. M., Perez-Exposito, A. B., Peerson, J. M., Dewey, K. G.. "Acceptability of a lipid-based nutrient supplement among Guatemalan infants and young children ." (2011)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Kumwenda, G., Nhlema, B., Maganga, G., Rogers, B., Walton, S., Boiteau, J., Webb, P.. "Feasibility and acceptability study of preparing corn soy blend with fortified vegetable oil in Malawi: Formative research ." USAID Food Aid Quality Review (2016)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Owino, V. O., Irena, A. H., Dibari, F., Collins, S.. "Development and acceptability of a novel milk-free soybean-maize-sorghum ready-to-use therapeutic food (SMS-RUTF) based on industrial extrusion cooking process ." Maternal & Child Health 10 , no. 1 (2014) : 126-134
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Locally produced
Research Gaps
  • Acceptability
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Lesorogol, C., Jean-Louis, S., Green, J., Iannotti, L. . "Preventative lipid-based nutrient supplements (LNS) and young child feeding practices: findings from qualitative research in Haiti ." Maternal & Child Nutrition 11 , no. S4 (2015) : 62-76
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight