Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 26 Results
Harriet Okronipa, Amado D Quezada-Sánchez, Susan L Johnson, Cloe Rawlinson, Selene Pacheco-Miranda, Mónica Venosa López, Anabelle Bonvecchio Arenas, Wendy Gonzalez Navarrete. "." Nutrients 12 , no. 10 (2020) : 3069
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Caroline Marquer, Céline Langendorf, Lynda Christelle Woi-Messe, Fatou Berthe, Eric-Alain Ategbo, Santiago Rodas-Moya, Saskia dePee,, and Rebecca F. Grais. "." BMC Nutrition 6 , no. 1 (2020) : 1-8
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Elizabeth T Rogawski McQuade, James A Platts-Mills, Jean Gratz, Jixian Zhang, Lawrence H Moulton, Kuda Mutasa, Florence D Majo, Naume Tavengwa, Robert Ntozini, Andrew J Prendergast, Jean H Humphrey, and Jie Liu, Eric R Houpt. "." Journal of Infectious Diseases (2019) : jiz179
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Environmental enteric dysfunction (EED)
  • Behavior change communication (BCC)
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Md. Iqbal Hossain, Sayeeda Huq, M. Munirul Islam, Tahmeed Ahmed.. "." European Journal of Nutrition (2019)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Dube, B., Rongsen, T., Mazumder, S., Taneja, S., Rafiqui, F., Bhandari, N., Bhan, M. K.. "Comparison of ready-to-use therapeutic food with cereal legume-based Khichri among malnourished children ." Indian Pediatrics 46 (2009) : 383-388
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Locally produced
Research Gaps
  • Acceptability
  • Composition
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Stevens, B., Watt, K., Brimblecombe, J., Clough, A., Judd, J.. "Development of a locally produced, balanced protein-energy food-based supplement and its acceptance by undernourished pregnant women in Northern Bangladesh ." Journal of Hunger & Environmental Nutrition (2016) : 100-115
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
Research Gaps
  • Acceptability
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Lanyero, B., Namusoke, H., Nabukeera-Barungi, N., Grenov, B., Mupere, E., Michaelsen, K. F., Molgaard, C., Christensen, V. B., Friis, H., Briend, A.. "Transition from F-75 to ready-to-use therapeutic food in children with severe acute malnutrition, an observational study in Uganda ." Nutrition Journal 16 , no. 1 (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Kampstra, N. A., Van Hoan, N., Koenders, D. J. P. C., Schoop, R., Broersen, C. B., Mouquet-Rivier, C., Traore, T., Bruins, M. J., de Pee, S.. "Energy and nutrient intake increased by 47–67% when amylase was added to fortified blended foods—a study among 12- to 35-month-old Burkinabe children ." Maternal & Child Nutrition (2017)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Thapa, B. R., Goyal, P., Menon, J., Sharma, A.. "Acceptability and efficacy of locally produced ready-to-use therapeutic food nutreal in the management of severe acute malnutrition in comparison with defined food: A randomized control trial ." Food and Nutrition Bulletin 38 , no. 1 (2017) : 18-26
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
Research Gaps
  • Acceptability
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Weber, J. M., Ryan, K. N., Tandon, R., Mathur, M., Girma, T., Steiner-Asiedu, M., Saalia, F., Zaidi, S., Soofi, S., Okos, M., Vosti, S. A.. "Acceptability of locally produced ready-to-use therapeutic foods in Ethiopia, Ghana, Pakistan and India ." Maternal & Child Nutrition 13 , no. 2 (2017) : e12250
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
Research Gaps
  • Acceptability
  • Cost
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Kumwenda, G., Nhlema, B., Maganga, G., Rogers, B., Walton, S., Boiteau, J., Webb, P.. "Feasibility and acceptability study of preparing corn soy blend with fortified vegetable oil in Malawi: Formative research ." USAID Food Aid Quality Review (2016)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Owino, V. O., Irena, A. H., Dibari, F., Collins, S.. "Development and acceptability of a novel milk-free soybean-maize-sorghum ready-to-use therapeutic food (SMS-RUTF) based on industrial extrusion cooking process ." Maternal & Child Health 10 , no. 1 (2014) : 126-134
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Locally produced
Research Gaps
  • Acceptability
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Cames, C., Varloteaux, M., Have, N. N., Diom, A. B.,, Msellati, P., Mbaye, N., Mbodji, H., Sy Signate, H., Diack, A., ANRS 12279 MAGGSEN Cohort Study. "Acceptability of outpatient ready-to-use food-based protocols in HIV-infected Senegalese children and adolescents within the MAGGSEN cohort study   ." Food and Nutrition Bulletin 38 , no. 1 (2016) : 27-36
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Bourdier, F.. "Socio-anthropological investigation related to the acceptability of Plumpy'nut in Cambodia ." Paris: institut de Recherche pour le Développement (2009)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Flax, V. L., Mäkinen, S., Ashorn, U., Cheung, Y. B., Maleta, K., Ashorn, P., Bentley, M. E.. "Responsive feeding and child interest in food vary when rural Malawian children are fed lipid‐based nutrient supplements or local complementary food ." Maternal & Child Nutrition 9 , no. 3 (2013) : 369-380
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Ali, E., Zachariah, R., Shams, Z., Manzi, M., Akter, T., Alders, P., Allaouna, M., Delchevalerie, P., Harries, A. D.. "Peanut-based ready-to-use therapeutic food: How acceptable and tolerated is it among malnourished pregnant and lactating women in Bangladesh? ." Maternal & Child Nutrition 11 , no. 4 (2015) : 1028-1035
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Ali, E., Zachariah, R., Dahmane, A., Van den Boogaard, W., Shams, Z., Akter, T., Alders, P., Manzi, M., Allaouna, M., Draguez, B., Delchevalerie, P., Harries, A. D.. "Peanut-based ready-to-use therapeutic food: acceptability among malnourished children and community workers in Bangladesh ." Public Health Action 3 , no. 2 (2013) : 128-135
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Flax, V. L., Thakwalakwa, C., Phuka, J., Ashorn, U., Cheung, Y. B., Maleta, K., Ashorn, P.. "Malawian mothers' attitudes towards the use of two supplementary foods for moderately malnourished children ." Appetite 53 , no. 2 (2009) : 195-202
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Scherbaum, V., Purwestri, R. C., Stuetz, W., Inayati, D. A., Suryantan, J., Bloem, M. A., Biesalski, H. K.. "Locally produced cereal/nut/legume-based biscuits versus peanut/milk-based spread for treatment of moderately to mildly wasted children in daily programmes on Nias Island, Indonesia: an issue of acceptance and compliance? ." Asia Pacific Journal of Clinical Nutrition 24 , no. 1 (2015) : 152
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Other
  • Behavior change communication (BCC)
  • Animal-source protein
Research Gaps
  • Acceptability
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Wang, R. J., Trehan, I., LaGrone, L. N., Weisz, A. J., Thakwalakwa, C. M., Maleta, K. M., Manary, M. J.. "Investigation of food acceptability and feeding practices for lipid nutrient supplements and blended flours used to treat moderate malnutrition ." Journal of Nutrition Education and Behavior 45 , no. 3 (2013) : 258-263
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Zebdewos, A., Singh, P., Birhanu, G., Whiting, S. J., Henry, C. J., Kebebu, A.. "Formulation of complementary food using amaranth, chickpea and maize improves iron, calcium and zinc content ." African Journal of Food, Agriculture, Nutrition and Development 15 , no. 4 (2015) : 10290-10304
Study Interventions
  • Plant-source protein
  • Locally produced
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Tripp, K., Perrine, C. G., de Campos, P., Knieriemen, M., Hartz, R., Jefferds, M. E., Kupka, R.. "Formative research for the development of a market‐based home fortification programme for young children in Niger ." Maternal & Child Nutrition 7 , no. Supplement 3 (2011) : 82-95
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
  • Treatment of Severe Acute Malnutrition
Iuel-Brockdorf, A. S., Draebel, T. A., Ritz, C., Fabiansen, C., Cichon, B., Brix Christensen, V., Yameogo, C., Oummani, R., Briend, A., Michaelsen, K. F., Ashorn, P., Filteau, S., Friis, H.. "Evaluation of the acceptability of improved supplementary foods for the treatment of moderate acute malnutrition in Burkina Faso using a mixed method approach ." Appetite 99 (2016) : 34-45
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Hess, S. Y., Bado, L., Aaron, G. J., Ouédraogo, J. B., Zeilani, M., Brown, K. H.. "Acceptability of zinc-fortified, lipid-based nutrient supplements (LNS) prepared for young children in Burkina Faso ." Maternal & Child Nutrition 7 , no. 4 (2011) : 357-367
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Phuka, J., Ashorn, U., Ashorn, P., Zeilani, M., Cheung, Y. B., Dewey, K. G., Manary, M., Maleta, K.. "Acceptability of three novel lipid-based nutrient supplements among Malawian infants and their caregivers ." Maternal & Child Nutrition 7 , no. 4 (2011) : 368-377
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Acceptability
  • Composition
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition