Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 26 Results
Xuejing Li, Yan Hui, Bingfeng Leng, Junli Ren, Yanni Song, Lianqiang Che, Xi Peng, Baojia Huang, Songling Liu, Lin Li, Dennis Sandris Nielsen, Yong Li, Xiaoshuang Dai, Shancen Zhao. "." PLoS One 16 , no. 4 (2021) : e0250423.
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Theresa Banda, Khataza Chawanda, Wakako Tsuchida, Slyvester Kathumba. "." Food and Nutrition Bulletin 42 , no. 1 (2021) : 91-103
Study Interventions
  • Plant-source protein
  • Experimental Lipid Based Nutrients
Research Gaps
  • Composition
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Brenda de Kok, Katie Moore, Leslie Jones, Katrien Vanslambrouck, Laeticia Celine Toe, Moctar Ouédraogo, Rasmané Ganaba, Saskia de Pee, Juliet Bedford, Carl Lachat, Patrick Kolsteren, Sheila Isanaka. "." Maternal & Child Nutrition (2021) : e13134
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Experimental Lipid Based Nutrients
Research Gaps
  • Acceptability
  • Efficacy
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Katrien Vanslambrouck, Brenda de Kok, Laeticia Celine Toe , Nathalie De Cock, Moctar Ouedraogo, Trenton Dailey-Chwalibóg, Giles Hanley-Cook, Rasmané Ganaba, Carl Lachat, Lieven Huybregts, Patrick Kolsteren. "." BMJ Open , no. 11 (2021) : e038393
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Efficacy
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Azimi F, Esmaillzadeh A, Alipoor E, Moslemi M, Yaseri M, Hosseinzadeh-Attar MJ. "." Public Health , no. 185 (2020) : 290-297
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
Research Gaps
  • Composition
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Rachel S. Bergmans, Maria Nikodemova, Valerie J. Stull, Ashley Rapp, Kristen M. C. Malecki. "." Plos ONE 15 , no. 6 (2020) : p.fiaa105.
Study Interventions
  • Animal-source protein
Research Gaps
  • Composition
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
David Taylor Hendrixson, Claire Godbout, Alyssa Los, Meghan Callaghan-Gillespie, Melody Mui, Donna Wegner, Taylor Bryant, Aminata Koroma, Mark J Manary. "." Gut (2020)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Composition
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Jadhav AR, Karnik P, Fernandes L, Fernandes S, Shah N, Manglani M.. "." Indian Pediatrics 56 , no. 4 (2019) : 287-293
Study Interventions
  • Locally produced
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Zeweter Abebe , Gulelat Desse Haki, Kaleab Baye. "." Maternal and Child Nutrition 14 , no. 1 (2017)
Study Interventions
  • Standard Fortified Food Blends
  • Other
  • Micronutrient powders (MNP)
Research Gaps
  • Efficacy
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Isanka, S., Kodish, S. R., Berthe, F., Alley, I., Nackers, F., Hanson, K. E., Grais, R. F.. "Outpatient treatment of severe acute malnutrition: response to treatment with a reduced schedule of therapeutic food distribution ." The American Journal of Clinical Nutrition (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Rogers, B. L., Wilner, L., Maganga, G., Walton, S., Suri, D. J., Langlois, B., Chui, K. K. H., Boiteau, J., Vosti, S., Webb, P.. "Program changes are effective and cost-effective in increasing the amount of oil used in preparing corn soy blend porridge for treatment of moderate acute malnutrition in Malawi ." Maternal & Child Nutrition (2017)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Cost
  • Efficacy
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Irena, A., Bahwere, P., Owino, V., Diop, E. I., Bachmann, M., Mbwili-Muleya, C., Dibari, F., Sadler, K., Collins, S.. "      ." Maternal & Child Nutrition 11 , no. S4 (2015) : 105-119
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Cost
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Thakwalakwa, C. M., Ashorn, P., Phuka, J. C., Cheung, Y. B., Briend, A., Maleta, K. M.. "Impact of lipid-based nutrient supplements and corn-soy blend on energy and nutrient intake among moderately underweight 8-18-month-old children participating in a clinical trial.  ." Maternal & Child Nutrition 11 , no. S4 (2015) : 144-150
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Shanka, N. A., Lemma, S., Abyu, D. M.. "Recovery rate and determinants in treatment of children with severe acute malnutrition using outpatient therapeutic feeding program in Kamba District, South West Ethiopia     ." Journal of Nutritional Disorders & Therapy 5 , no. 2 (2015)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Kerac, M., Bunn, J., Seal, A., Thindwa, M., Tomkins, A., Sadler, K., Bahwere, P., Collins, S.. "Probiotics and prebiotics for severe acute malnutrition (PRONUT study): a double-blind efficacy randomised controlled trial in Malawi ." The Lancet 374 , no. 9684 (2009) : 136-144
Study Interventions
  • Other
  • Animal-source protein
Research Gaps
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Sethuraman, K., Doledec, D., Begum, F., Manir, M. Z.. "Managing acute malnutrition: A review of the evidence and country experiences in South Asia and a recommended approach for Bangladesh ." FANTA Project (2014)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
  • Animal-source protein
Research Gaps
  • Effectiveness
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Caulfield, L. E., Huffman, S. L., Piwoz, E. G.. "." Food and Nutrition Bulletin 2 , no. 2 (1999) : 183-200
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
  • Efficacy
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Ningadalli, S. G., Angolkar, M., Herekar, V. R., Hirachand, A. D., Sah, J. K., Madikar, S.. "." International Journal of Science and Research 4 , no. 5 (2015) : 2133-2137
Study Interventions
  • Other
  • Behavior change communication (BCC)
Research Gaps
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Nguefack, F., Adjahoung, C. A., Keugoung, B., Kamgaing, N., Dongmo, R.. "Hospital management of severe acute malnutrition in children with F-75 and F-100 alternative local preparations: results and challenges ." The Pan African Medical Journal 21 (2015) : 329
Study Interventions
  • Animal-source protein
  • Locally produced
Research Gaps
  • Composition
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Amegovu, Andrew Kiri, Ochola, Sophie, Ogwok, Patrick, Yiga, Peter, Musalima, Juliet, Juliana, Mandha. "Efficacy of sorghum peanut blend and corn soy blend plus in the treatment of moderate acute malnutrition in children aged 6–59 months in Karamoja, Uganda: a cluster randomized trial ." Nutrition & Dietary Supplements 6 (2014) : 75-84
Study Interventions
  • Standard Fortified Food Blends
  • Plant-source protein
  • Locally produced
Research Gaps
  • Composition
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Diop, E. H. I., Dossou, N. I., Ndour, M. M., Briend, A., Wade, S.. "Comparison of the efficacy of a solid ready-to-use food and a liquid, milk-based diet for the rehabilitation of severely malnourished children: A randomized trial ." American Journal of Clinical Nutrition 78 , no. 2 (2003) : 302-307
Study Interventions
  • Animal-source protein
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Other
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Ige, O. K., Oladokun, R. E., Kikelomo, O.. "." South African Journal of Child Health 8 , no. 3 (2014) : 104-107
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Babirekere-Iriso, E., Mortensen, C. G., Mupere, E., Rytter, M. J., Namusoke, H., Michaelsen, K. F., Briend, A., Stark, K. D., Friis, H., Lauritzen, L.. "Changes in whole-blood PUFA and their predictors during recovery from severe acute malnutrition ." The British Journal of Nutrition 115 , no. 10 (2016) : 1730-9
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Animal-source protein
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Namusoke, H., Hother, A., Rytter, M. J., Kæstel, P., Babirekere-Iriso, E., Fabiansen, C., Girma, T., Ritz, C., Michaelsen, K., Briend, A., Friis, H.. "Changes in plasma phosphate during in-patient treatment of children with severe acute malnutrition: an observational study in Uganda ." The American Journal of Clinical Nutrition (2016)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Animal-source protein
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Bahwere, P., Balaluka, B., Wells, J. C., Mbiribindi, C. N., Sadler, K., Akomo, P., Dramaix-Wilmet, M., Collins, S.. "Cereals and pulse-based ready-to-use therapeutic food as an alternative to the standard milk- and peanut paste-based formulation for treating severe acute malnutrition: a noninferiority, individually randomized controlled efficacy clinical trial ." The American Journal of Clinical Nutrition 103 , no. 4 (2016) : 1145-1161
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Locally produced
  • Animal-source protein
Research Gaps
  • Composition
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition