Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 108 Results
Xuejing Li, Yan Hui, Bingfeng Leng, Junli Ren, Yanni Song, Lianqiang Che, Xi Peng, Baojia Huang, Songling Liu, Lin Li, Dennis Sandris Nielsen, Yong Li, Xiaoshuang Dai, Shancen Zhao. "." PLoS One 16 , no. 4 (2021) : e0250423.
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Azimi F, Esmaillzadeh A, Alipoor E, Moslemi M, Yaseri M, Hosseinzadeh-Attar MJ. "." Public Health , no. 185 (2020) : 290-297
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
Research Gaps
  • Composition
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Rachel S. Bergmans, Maria Nikodemova, Valerie J. Stull, Ashley Rapp, Kristen M. C. Malecki. "." Plos ONE 15 , no. 6 (2020) : p.fiaa105.
Study Interventions
  • Animal-source protein
Research Gaps
  • Composition
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Meghan Callaghan, Momo Oyama, Mark Manary. "." The Journal of Nutrition 147 , no. 3 (2020) : 277–280
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
David Taylor Hendrixson, Claire Godbout, Alyssa Los, Meghan Callaghan-Gillespie, Melody Mui, Donna Wegner, Taylor Bryant, Aminata Koroma, Mark J Manary. "." Gut (2020)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Composition
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Mark Manary, Meghan Callaghan-Gillespie. "." Global Landscape of Nutrition Challenges in Infants and Children 93 (2020) : 111-120
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
Research Gaps
  • Cost
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
  • Treatment of Moderate Acute Malnutrition
Rosalie H. Bartels, Emmanuel Chimwezi, Victoria Watson, Leilei Pei, Isabel Potani, Benjamin Allubha, Kate Chidzalo, Duolao Wang, Queen Dube, Macpherson Mallewa, Angela Allen, Robert H. J. Bandsma, Wieger P. Voskuijl and Stephen J. Allen . "." Scientific Reports, Nature Publishing 9 , no. 1 (2019)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Ayse Ercumen ,Jade Benjamin-Chung ,Benjamin F. Arnold,Audrie Lin,Alan E. Hubbard, Christine Stewart, Zahidur Rahman, Sarker Masud Parvez, Leanne Unicomb, Mahbubur Rahman, Rashidul Haque, John M. Colford Jr., and Stephen P. Luby. "." PLoS Neglected Tropical Diseases 13 , no. 5 (2019)
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Laura Adubra, Agnes Le Port, Yves Kameli, Sonia Fortin, Tanimoune Mahamadou, Marie T Ruel, Yves Martin-Prevel, and Mathilde Savy. "." American Journal of Clinical Nutrition 110 , no. 6 (2019) : 1476–1490
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Cash transfer
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
  • Treatment of Severe Acute Malnutrition
R. B. Kajjura, F. J. Veldman, S. M. Kassier. "." Journal of Human Nutrition and Dietetics 32 , no. 3 (2019) : 295–302
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Elodie Becquey, Lieven Huybregts, Amanda Zongrone, Agnes Le Port, Jef L. Leroy, Rahul Rawat, Mariama Touré, Marie T. Ruel. "." PLOS Medicine 16 , no. 8 (2019)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Emanuela Galasso, Ann M Weber, Christine P Stewart, Lisy Ratsifandrihamanana, Lia C H Fernald. "." Lancet Global Health 7 , no. 9 (2019) : 1257-1268
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Peter Akomo, Paluku Bahwere, Hitoshi Murakami, Chrissy Banda, Elizabeth Maganga, Sylvester Kathumba, Kate Sadler, Steve Collins . "." BMC Public Health 19 , no. 1 (2019)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Julie M Long, Prasenjit Mondal, Jamie E Westcott, Leland V Miller, M Munirul Islam, Mondar Ahmed, Mustafa Mahfuz, Tahmeed Ahmed, Nancy F Krebs.. "." Journal of Nutrition 149 , no. 1 (2019) : 98–105
Study Interventions
  • Standard Fortified Food Blends
  • Environmental enteric dysfunction (EED)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Gladstone MJ, Chandna J, Kandawasvika G, Ntozini R, Majo FD, Tavengwa NV, Mbuya MNN, Mangwadu GT, Chigumira A, Chasokela CM, Moulton LH, Stoltzfus RJ, Humphrey JH, Prendergast AJ; SHINE Trial Team.. "." PLoS Medicine 16 , no. 3 (2019)
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Humphrey JH, Mbuya MNN, Ntozini R, Moulton LH, Stoltzfus RJ, Tavengwa NV, Mutasa K, Majo F, Mutasa B, Mangwadu G, Chasokela CM, Chigumira A, Chasekwa B, Smith LE, Tielsch JM, Jones AD, Manges AR, Maluccio JA, Prendergast AJ; SHINE Team. "." Lancet Global Health 7 , no. 1 (2019) : e132-e147
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Delimont NM, Vahl CI, Kayanda R, Msuya W, Mulford M, Alberghine P, Praygod G, Mngara J, Alavi S, Lindshield BL. "." Current Developments in Nutrition 3 , no. 6 (2019)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Maku E Ocansey, Seth Adu-Afarwuah, Sika M Kumordzie, Harriet Okronipa, Rebecca R Young, Solace M Tamakloe, Brietta M Oaks, Kathryn G Dewey, and Elizabeth L Prado. "." The American Journal of Clinical Nutrition 109 , no. 2 (2019) : 322–334
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Deanna K Olney, Jef Leroy, Lilia Bliznashka, and Marie T Ruel. " Background Food-assisted maternal and child health and nutrition (FA-MCHN) programs may foster child growth during the first 1000 d (pregnancy and the first 2 y of a child's life), but evidence is scant. Objective We evaluated the impact of an FA-MCHN program, PROCOMIDA, on linear growth (stunting [length-for-age z score (LAZ) < –2] and length-for-age difference [LAD]) among children aged 1–24 mo. PROCOMIDA was implemented in Guatemala by Mercy Corps and was available to beneficiaries throughout the first 1000 d. Methods We used a longitudinal, cluster-randomized controlled trial with groups varying in family ration sizes [full (FFR), reduced (RFR), and none (NFR)] and individual ration types provided to mothers (pregnancy to 6 mo postpartum) and children (6–24 mo of age) [corn-soy blend (CSB), lipid-based nutrient supplement (LNS), micronutrient powder (MNP)]: 1) FFR + CSB (n = 576); 2) RFR + CSB (n = 575); 3) NFR + CSB (n = 542); 4) FFR + LNS (n = 550); 5) FFR + MNP (n = 587); 6) control (n = 574). Program impacts compared with control, and differential impacts between groups varying family ration size or individual ration type, were assessed through the use of linear mixed-effects models and post hoc simple effect tests (significant if P < 0.05). Results PROCOMIDA significantly reduced stunting at age 1 mo in FFR + CSB, RFR + CSB, and FFR + MNP groups compared with control [5.05, 4.06, and 3.82 percentage points (pp), respectively]. Stunting impact increased by age 24 mo in FFR + CSB and FFR + MNP relative to control (impact = 11.1 and 6.5 pp at age 24 mo, respectively). For CSB recipients, the FFR compared with RFR or NFR significantly reduced stunting (6.47–9.68 pp). CSB reduced stunting significantly more than LNS at age 24 mo (8.12 pp). Conclusions FA-MCHN programs can reduce stunting during the first 1000 d, even in relatively energy/food-secure populations. Large family rations with individual rations of CSB or MNP were most effective. The widening of impact as children age highlights the importance of intervening throughout the full first 1000 d. ." The Journal of Nutrition 148 , no. 9 (2018) : 1493–1505
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Bindi Borg, Seema Mihrshahi, Mark Griffin, Daream Sok, Chamnan Chhoun, Arnaud Laillou, Frank T. Wieringa. "." Maternal & Child Nutrition 15 , no. 3 (2019)
Study Interventions
  • Standard Fortified Food Blends
  • Locally produced
Research Gaps
  • Acceptability
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Soofi S, Nawaz G, Garzon C.. "." Curren Developments in Nutrition Supp 1 , no. 3 (2019)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Taylor S, Silver R, Franceschini M, Muentener P, de Sa AB, Co R, Sonco A, Balé C, Saltzman E, Roberts S. "    ." Current Developments in Nutrition 3 , no. Supp 1 (2019)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Isanaka S, Barnhart DA, McDonald CM, Ackatia-Armah RS, Kupka R, Doumbia S, Brown KH, Menzies NA. "." BMJ Global Health 4 , no. 2 (2019)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Cost
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Sibson VL, Grijalva-Eternod CS, Noura G, Lewis J, Kladstrup K, Haghparast-Bidgoli H, Skordis-Worrall, Colbourn T, Morrison J, Seal AJ. "." Maternal & Child Nutrition 14 , no. 4 (2018)
Study Interventions
  • Cash transfer
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Jessica Bliss, Kate Golden, Leila Bourahla, Rebecca Stoltzfus, David Pelletier. "." Journal of Global Health 8 , no. 1 (2018)
Study Interventions
  • Cash transfer
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight