Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 65 Results
Melissa F Young, Rukshan V Mehta, Lucas Gosdin, Priya Kekre, Pankaj Verma, Leila M Larson, Amy Webb Girard, Usha Ramakrishnan, Indrajit Chaudhuri, Sridhar Srikantiah, Reynaldo Martorell. "." The Journal of Nutrition 151 , no. 7 (2021) : 1983-1992
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Marius Affonfere, Flora Josiane Chadare, Finagnon Toyi Kévin Fassinou, Elise F. Talsma, Anita R. Linnemann, Paulin Azokpota. "." Food Science & Nutrition (2021)
Study Interventions
  • Micronutrient powders (MNP)
  • Locally produced
Research Gaps
  • Acceptability
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Katrien Vanslambrouck, Brenda de Kok, Laeticia Celine Toe , Nathalie De Cock, Moctar Ouedraogo, Trenton Dailey-Chwalibóg, Giles Hanley-Cook, Rasmané Ganaba, Carl Lachat, Lieven Huybregts, Patrick Kolsteren. "." BMJ Open , no. 11 (2021) : e038393
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Efficacy
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Shehla Zaidi , Jai K. Das, Gul Nawaz Khan, Rabia Najmi, Mashal Murad Shah, Sajid B. Soofi. "." BMC Public Health 20 , no. 1 (2020) : 1046
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Micronutrient powders (MNP)
Research Gaps
  • Acceptability
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Seth Adu-Afarwuah, Rebecca R Young, Anna Lartey, Harriet Okronipa, Per Ashorn, Ulla Ashorn, Brietta M Oaks, Kathryn G Dewey. "." Journal of Nutrition (2019) : nxz243
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Bindi Borg , Daream Sok, Seema Mihrshahi, Mark Griffin, Chhoun Chamnan, Jacques Berger, Arnaud Laillou, Nanna Roos, and Frank T. Wieringa. "." Maternal and Child Nutrition 16 , no. 1 (2020)
Study Interventions
  • Standard Fortified Food Blends
  • Micronutrient powders (MNP)
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Minyanga Nkhoma, Per Ashorn, Ulla Ashorn, Kathryn G. Dewey, Austrida Gondwe, and Kenneth Maleta . "." PLoS One 14 , no. 5 (2019)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Julie M Long, Prasenjit Mondal, Jamie E Westcott, Leland V Miller, M Munirul Islam, Mondar Ahmed, Mustafa Mahfuz, Tahmeed Ahmed, Nancy F Krebs.. "." Journal of Nutrition 149 , no. 1 (2019) : 98–105
Study Interventions
  • Standard Fortified Food Blends
  • Environmental enteric dysfunction (EED)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Deanna K Olney, Jef Leroy, Lilia Bliznashka, and Marie T Ruel. " Background Food-assisted maternal and child health and nutrition (FA-MCHN) programs may foster child growth during the first 1000 d (pregnancy and the first 2 y of a child's life), but evidence is scant. Objective We evaluated the impact of an FA-MCHN program, PROCOMIDA, on linear growth (stunting [length-for-age z score (LAZ) < –2] and length-for-age difference [LAD]) among children aged 1–24 mo. PROCOMIDA was implemented in Guatemala by Mercy Corps and was available to beneficiaries throughout the first 1000 d. Methods We used a longitudinal, cluster-randomized controlled trial with groups varying in family ration sizes [full (FFR), reduced (RFR), and none (NFR)] and individual ration types provided to mothers (pregnancy to 6 mo postpartum) and children (6–24 mo of age) [corn-soy blend (CSB), lipid-based nutrient supplement (LNS), micronutrient powder (MNP)]: 1) FFR + CSB (n = 576); 2) RFR + CSB (n = 575); 3) NFR + CSB (n = 542); 4) FFR + LNS (n = 550); 5) FFR + MNP (n = 587); 6) control (n = 574). Program impacts compared with control, and differential impacts between groups varying family ration size or individual ration type, were assessed through the use of linear mixed-effects models and post hoc simple effect tests (significant if P < 0.05). Results PROCOMIDA significantly reduced stunting at age 1 mo in FFR + CSB, RFR + CSB, and FFR + MNP groups compared with control [5.05, 4.06, and 3.82 percentage points (pp), respectively]. Stunting impact increased by age 24 mo in FFR + CSB and FFR + MNP relative to control (impact = 11.1 and 6.5 pp at age 24 mo, respectively). For CSB recipients, the FFR compared with RFR or NFR significantly reduced stunting (6.47–9.68 pp). CSB reduced stunting significantly more than LNS at age 24 mo (8.12 pp). Conclusions FA-MCHN programs can reduce stunting during the first 1000 d, even in relatively energy/food-secure populations. Large family rations with individual rations of CSB or MNP were most effective. The widening of impact as children age highlights the importance of intervening throughout the full first 1000 d. ." The Journal of Nutrition 148 , no. 9 (2018) : 1493–1505
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Nawaz G, Ariff S, Habib A, Kureishy S, Garzon C, Ihtesham Y, Khan AA, Sajid M, Ahmed I, Soofi S. "." Current Developments in Nutrition 3 (2019)
Study Interventions
  • Micronutrient powders (MNP)
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Javeria Saleem, Rubeena Zakar, Muhammad Z Zakar, Mulugeta Belay, Marion Rowe, Peter M Timms, Robert Scragg, Adrian R Martineau. "." American Journal of Clinical Nutrition 107 , no. 5 (2018) : 725-733
Study Interventions
  • Standard Fortified Food Blends
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Boris Martinez, Meghan Farley Webb, Ana Gonzalez, Kate Douglas, Maria del Pilar Grazioso, Peter Rohloff. "." BMJ Paediatrics Open 2 , no. 1 (2018)
Study Interventions
  • Other
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Audrie Lin , Benjamin F Arnold, Andrew N Mertens, Jue Lin, Jade Benjamin-Chung, Shahjahan Ali, Alan E Hubbard, Christine P Stewart, Abul K Shoab, Md Ziaur Rahman, Md Saheen Hossen, Palash Mutsuddi, Syeda L Famida, Salma Akther, Mahbubur Rahman, Leanne Unic. "." eLife 6 (2017)
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Shabina Ariff, Nancy F. Krebs, Sajid Soofi, Jamie Westcott, Zaid Bhatti, Farhana Tabassum, Zulfiqar A. Bhutta. "." The Journal of Nutrition 141 , no. 1 (2014) : 20-26
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Marly A. Cardoso , Rosangela A. Augusto, Gisele A. Bortolini, Cristieli S. M. Oliveira, Daniela C. Tietzman, Leopoldina A. S. Sequeira, Maria Claret C. M. Hadler, Maria do Rosario G. Peixoto, Pascoal T. Muniz, Márcia R. Vitolo, Pedro I. C. Lira, Patrícia C. Jaime, ENFAC Working Group. "." PLOS ONE 11 , no. 5 (2016)
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Heather C Stobaugh, Lucy B Bollinger, Sara E Adams, Audrey H Crocker, Jennifer B Grise, Julie A Kennedy, Chrissie Thakwalakwa, Kenneth M Maleta, Dennis J Dietzen , Mark J Manary, Indi Trehan. "." The American Journal of Clinical Nutrition 106 , no. 2 (2017) : 657-666
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Zeweter Abebe , Gulelat Desse Haki, Kaleab Baye. "." Maternal and Child Nutrition 14 , no. 1 (2017)
Study Interventions
  • Standard Fortified Food Blends
  • Other
  • Micronutrient powders (MNP)
Research Gaps
  • Efficacy
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Susan B. Roberts, Maria Angela Franceschini, Amy Krauss, Pei-Yi Lin, Augusto Braima de Sa, Raimundo Co ́, SalimaTaylor, Carrie Brown, Oliver Chen, Elizabeth J. Johnson, William Pruzensky, Nina Schlossman, Carlito Bale ́, Kuan-Cheng (Tony) Wu, Katherine Hagan, Edward Saltzman, Paul Muentener. "." Current Developments in Nutrition 1 , no. 11 (2017)
Study Interventions
  • Standard Fortified Food Blends
  • Micronutrient powders (MNP)
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Kounnavong, S., Sunahara, T., Mascie-Taylor, C. G. N., Hasizume, M., Okumura, J., Moji, K., Boupha, B., Yamamoto, T.. "." Nutrition Journal 10 , no. 129 (2011)
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Korenromp, E. L., Adeosun, O., Adegoke, F., Akerele, A., Anger, C., Ohajinwa, C., Hotz, C., Umunna, L., Aminu, F.. "." Public Health Nutrition 19 , no. 10 (2015) : 1882-1892
Study Interventions
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Ziauddin Hyder, S. M., Haseen, F., Rahman, M., Tondeur, M. C., Zlotkin, S. H.. "Effect of daily versus once-weekly home fortification with micronutrient Sprinkles on hemoglobin and iron status among young children in rural Bangladesh ." Food and Nutrition Bulletin 28 , no. 7 (2007)
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Hirve, S., Martini, E., Juvekar, S. K., Agarwal, D., Bavdekar, A., Sari, M., Molwane, M., Janes, S., Haselow, N., Yeung, D. L., Pandit, A.. "." The Indian Journal of Pediatrics 80 , no. 12 (2013) : 990-995
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
de Pee, S., Moench-Pfanner, R., Martini, E., Zlotkin, S. H., Darnton-Hill, I., Bloem, M. W.. "." Food and Nutrition Bulletin 28 , no. 2 (2007) : 189-197
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Avula, R., Frongillo, E. A., Arabi, M., Sharma, S., Schultink, W.. "Enhancements to nutrition program in Indian Integrated Child Development Services increased growth and energy intake of children ." The Journal of Nutrition 141 (2011) : 680-684
Study Interventions
  • Other
  • Micronutrient powders (MNP)
  • Locally produced
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Suchdev, P. S., Addo, O. Y., Martorell, R., Grant, F. K. E., Ruth, L. J., Patel, M. K., Juliao, P. C., Quick, R., Flores-Ayala, R.. "Effects of community-based sales of micronutrient powders on morbidity episodes in preschool children in Western Kenya ." American Journal of Clinical Nutrition 103 , no. 3 (2016) : 934-941
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight