Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 50 Results
Mette F. Olsen, Ann-Sophie Iuel-Brockdorff, Charles W. Yaméogo, Bernardette Cichon, Christian Fabiansen, Suzanne Filteau, Kevin Phelan, Albertine Ouédraogo, Kim F. Michaelsen, Melissa Gladstone, Per Ashorn, André Briend, Christian Ritz, Henrik Friis, Vibeke B. Christ. "." PLoS medicine 17 , no. 12 (2020) : e1003442
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Animal-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Stark, Heather, Anteneh Omer, Aïssata Wereme N'Diaye, Amanda C. Sapp, Emily V. Moore, Sarah L. McKune. "." Maternal & Child Nutrition (2020) : e13069
Study Interventions
  • Behavior change communication (BCC)
  • Locally produced
  • Animal-source protein
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Rachel S. Bergmans, Maria Nikodemova, Valerie J. Stull, Ashley Rapp, Kristen M. C. Malecki. "." Plos ONE 15 , no. 6 (2020) : p.fiaa105.
Study Interventions
  • Animal-source protein
Research Gaps
  • Composition
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Rebecca Roediger, Hans-Henrik Stein, Meghan Callaghan-Gillespie , Jeffrey Kahn Blackman, Kristin Kohlmann, Kenneth Maleta, Mark Manary. "." Maternal & Child Nutrition , no. e13019 (2020)
Study Interventions
  • Animal-source protein
  • Standard Fortified Food Blends
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Bahwere, P., Akomo, P., Mwale, M., Murakami, H., Banda, C., Kathumba, S., Banda, C., Jere, S., Sadler, K., Collins, S.. "." American Journal of Clinical Nutrition (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Sulistiyono, P., Herawati, D. M. D., Arya, I. F. D.. "Rebon shrimp powder addition influence to nutritional values, organoleptic properties and acceptance of supplementary food by children aged 4-5 years old ." Kesmas: National Public Health Journal 11 , no. 4 (2017) : 168-172
Study Interventions
  • Locally produced
  • Animal-source protein
Research Gaps
  • Acceptability
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Isanka, S., Menzies, N. A., Sayyad, J., Ayoola, M., Grais, R. F., Doyon, S.. "Cost analysis of the treatment of severe acute malnutrition in West Africa ." Maternal & Child Nutrition (2016)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Animal-source protein
Research Gaps
  • Cost
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Irena, A., Bahwere, P., Owino, V., Diop, E. I., Bachmann, M., Mbwili-Muleya, C., Dibari, F., Sadler, K., Collins, S.. "      ." Maternal & Child Nutrition 11 , no. S4 (2015) : 105-119
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Cost
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Koroma, A., Manary, M., Marron, B., Green, J., Rogers, B., Walton, S., Chui, K. H. K., Suri, D., Langlois, B., Jayson, L., Boiteau, J., Rosenberg, I., de Pee, S., Vosti, S., Webb, P.. "Comparison of four supplementary foods in treating moderate acute malnutrition in Sierra Leone: an Ebola-constrained cluster-randomized, controlled clinic-based effectiveness trial: A Report from the Food Aid Quality Review ." (2015)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Cost
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Skau, J. K. H., Bunthang, T., Chamnan, C., Wieringa, F. T., Dijkhuizen, M. A., Roos, N., Ferguson, E. L.. "The use of linear programming to determine whether a formulated complementary food product can ensure adequate nutrients for 6- to 11-month-old Cambodian infants ." The American Journal of Clinical Nutrition 99 , no. 1 (2014) : 130-8
Study Interventions
  • Standard Fortified Food Blends
  • Plant-source protein
  • Locally produced
  • Animal-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Matilsky, D. K., Maleta, K., Castleman, T., Manary, M. J.. "Supplementary feeding with fortified spreads results in higher recovery rates than with a corn/soy blend in moderately wasted children ." The Journal of Nutrition 139 , no. 4 (2009) : 773-778
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Micronutrient powders (MNP)
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Burza, S., Mahajan, R., Marino, E., Sunyoto, T., Shandilya, C., Tabrez, M., Kumar, K., Jha, A, Mathew, P., Salse, N., Casademont, C., Mishra, N. K.. "Seasonal effect and long-term nutritional status following exit from a Community-Based Management of Severe Acute Malnutrition program in Bihar, India ." European Journal of Clinical Nutrition 70 , no. 4 (2016) : 437-44
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Animal-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Lakkam, M., Wager, S., Wise, P. H., Wein, L. M.. "Quantifying and exploiting the age dependence in the effect of supplementary food for child undernutrition ." PloS One 9 , no. 6 (2014) : e99632
Study Interventions
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Maleta, K. M., Phuka, J., Alho, L., Cheung, Y. B., Dewey,K. G., Ashorn, U., Phiri, N., Phiri, T. E., Vosti, S. A., Zeilani, M., Kumwenda, C., Bendabenda, J., Pulakka, A., Ashorn, P.. "Provision of 10–40 g/d lipid-based nutrient supplements from 6 to 18 months of age does not prevent linear growth faltering in Malawi   ." The Journal of Nutrition 145 , no. 8 (2015) : 1909-15
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Mangani, C., Cheung, Y. B., Maleta, K., Phuka, J., Thakwalakwa, C., Dewey, K., Manary, M., Puumalainen, T., Ashorn, P.. "Providing lipid-based nutrient supplements does not affect developmental milestones among Malawian children ." Acta Paediatrica 103 , no. 1 (2014) : e17-26
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Kerac, M., Bunn, J., Seal, A., Thindwa, M., Tomkins, A., Sadler, K., Bahwere, P., Collins, S.. "Probiotics and prebiotics for severe acute malnutrition (PRONUT study): a double-blind efficacy randomised controlled trial in Malawi ." The Lancet 374 , no. 9684 (2009) : 136-144
Study Interventions
  • Other
  • Animal-source protein
Research Gaps
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Shamim, A. A., Hanif, Abu A. M., Merrill, R. D., Campbell, R. K., Kumkum, M. A., Shaikh, S., de Pee, S., Ahmed, T., Parveen, M., Mehra, S., Klemm, R. D. W., Labrique, A. B., West, K. P., Christian, P.. "Preferred delivery method and acceptability of Wheat-Soy Blend (WSB++) as a daily complementary food supplement in northwest Bangladesh     ." Ecology of Food and Nutrition 54 , no. 1 (2015) : 74-92
Study Interventions
  • Standard Fortified Food Blends
  • Animal-source protein
Research Gaps
  • Acceptability
  • Innovation
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Caparros Megido, R., Alabi, T., Nieus, C., Blecker, C., Danthine, ., Bogaert, J., Haubruge, E., Francis, F.. "Optimisation of a cheap and residential small‐scale production of edible crickets with local by‐products as an alternative protein‐rich human food source in Ratanakiri Province, Cambodia ." Journal of the Science of Food and Agriculture 96 , no. 2 (2015) : 627-632
Study Interventions
  • Locally produced
  • Animal-source protein
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Tang, M., Sheng, X. Y., Krebs, N. F., Hambidge, K. M.. "Meat as complementary food for older breastfed infants and toddlers: a randomized, controlled trial in rural China ." Food and Nutrition Bulletin 35 , no. 4 Suppl (2014) : S188-192
Study Interventions
  • Plant-source protein
  • Locally produced
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Sethuraman, K., Doledec, D., Begum, F., Manir, M. Z.. "Managing acute malnutrition: A review of the evidence and country experiences in South Asia and a recommended approach for Bangladesh ." FANTA Project (2014)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
  • Animal-source protein
Research Gaps
  • Effectiveness
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Ashorn, U., Alho, L., Arimond, M., Dewey, K. G., Maleta, K., Phiri, N., Phuka, J., Vosti, S. A., Zeilani, M., Ashorn, P.. "Malawian mothers consider lipid-based nutrient supplements acceptable for children throughout a 1-year intervention, but deviation from user recommendations is common ." The Journal of Nutrition 145 , no. 7 (2015) : 1588-1595
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Scherbaum, V., Purwestri, R. C., Stuetz, W., Inayati, D. A., Suryantan, J., Bloem, M. A., Biesalski, H. K.. "Locally produced cereal/nut/legume-based biscuits versus peanut/milk-based spread for treatment of moderately to mildly wasted children in daily programmes on Nias Island, Indonesia: an issue of acceptance and compliance? ." Asia Pacific Journal of Clinical Nutrition 24 , no. 1 (2015) : 152
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Other
  • Behavior change communication (BCC)
  • Animal-source protein
Research Gaps
  • Acceptability
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Singh, A. S., Kang, G., Ramachandran, A., Sarkar, R., Peter, P., Bose, A.. "Locally made ready to use therapeutic food for treatment of malnutrition a randomized controlled trial ." Indian Pediatrics 47 , no. 8 (2010)
Study Interventions
  • Standard Fortified Food Blends
  • Locally produced
  • Animal-source protein
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Dewey, K. G., Arimond, M.. "Lipid-based nutrient supplements: how can they combat child malnutrition? ." PLoS Medicine 9 , no. 9 (2012) : e1001314
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
  • Treatment of Severe Acute Malnutrition
Wang, R. J., Trehan, I., LaGrone, L. N., Weisz, A. J., Thakwalakwa, C. M., Maleta, K. M., Manary, M. J.. "Investigation of food acceptability and feeding practices for lipid nutrient supplements and blended flours used to treat moderate malnutrition ." Journal of Nutrition Education and Behavior 45 , no. 3 (2013) : 258-263
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition