Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 51 Results
Theresa Banda, Khataza Chawanda, Wakako Tsuchida, Slyvester Kathumba. "." Food and Nutrition Bulletin 42 , no. 1 (2021) : 91-103
Study Interventions
  • Plant-source protein
  • Experimental Lipid Based Nutrients
Research Gaps
  • Composition
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Mark Manary, Meghan Callaghan-Gillespie. "." Global Landscape of Nutrition Challenges in Infants and Children 93 (2020) : 111-120
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
Research Gaps
  • Cost
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
  • Treatment of Moderate Acute Malnutrition
Breanne K Langlois, Ilana R Cliffer, Laetitia Nikiema, Devika J Suri, Franck Garanet, Ye Shen, Augustin N Zeba, Shelley M Walton, Hermann B Lanou, Patrick Webb, and Beatrice L Rogers. "." Current Developments in Nutrition 4 , no. 2 (2020)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
M Isabel Ordiz, Richard D Semba, Ruin Moaddel, Ulrike Rolle-Kampczyk, Martin von Bergen, Gunda Herberth, Mohammed Khadeer, Stefan Röder, Mark J Manary. "." Current Developments in Nutrition 3 , no. 10 (2019)
Study Interventions
  • Standard Fortified Food Blends
  • Plant-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Bahwere, P., Akomo, P., Mwale, M., Murakami, H., Banda, C., Kathumba, S., Banda, C., Jere, S., Sadler, K., Collins, S.. "." American Journal of Clinical Nutrition (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Bhandari, N., Mohan, S. B., Bose, A., Iyengar, S. D., Taneja, S., Mazumder, S., Pricilla, R. A., Iyengar, K., Sachdev, H. S., Mohan, V. R., Suhalka, V., Yoshida, S., Martines, J., Bahl, R.. "Efficacy of three feeding regimens for home-based management of children with uncomplicated severe acute malnutrition: a randomised trial in India ." BMJ Global Health 1 , no. e000144 (2016)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Other
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Jie, C.. "Improve nutrition, food safety, and food security for China’s most vulnerable women and children – Joint final evaluation ." International Labor Office - Evaluation Unit (2013)
Study Interventions
  • Micronutrient powders (MNP)
  • Plant-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Dani, V., Stav, A., Pendharkar, J., Satav, K., Sadanshiv, A., Adhav, A. S., Thakare, B.. "Community-based management of severe malnutrition: SAM and SUW in children under five in the Melghat tribal area, central India ." ENN Field Exchange 52 (2016) : 27
Study Interventions
  • Plant-source protein
  • Behavior change communication (BCC)
  • Locally produced
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Irena, A., Bahwere, P., Owino, V., Diop, E. I., Bachmann, M., Mbwili-Muleya, C., Dibari, F., Sadler, K., Collins, S.. "      ." Maternal & Child Nutrition 11 , no. S4 (2015) : 105-119
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Cost
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Koroma, A., Manary, M., Marron, B., Green, J., Rogers, B., Walton, S., Chui, K. H. K., Suri, D., Langlois, B., Jayson, L., Boiteau, J., Rosenberg, I., de Pee, S., Vosti, S., Webb, P.. "Comparison of four supplementary foods in treating moderate acute malnutrition in Sierra Leone: an Ebola-constrained cluster-randomized, controlled clinic-based effectiveness trial: A Report from the Food Aid Quality Review ." (2015)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Cost
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Owino, V. O., Irena, A. H., Dibari, F., Collins, S.. "Development and acceptability of a novel milk-free soybean-maize-sorghum ready-to-use therapeutic food (SMS-RUTF) based on industrial extrusion cooking process ." Maternal & Child Health 10 , no. 1 (2014) : 126-134
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Locally produced
Research Gaps
  • Acceptability
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Cames, C., Varloteaux, M., Have, N. N., Diom, A. B.,, Msellati, P., Mbaye, N., Mbodji, H., Sy Signate, H., Diack, A., ANRS 12279 MAGGSEN Cohort Study. "Acceptability of outpatient ready-to-use food-based protocols in HIV-infected Senegalese children and adolescents within the MAGGSEN cohort study   ." Food and Nutrition Bulletin 38 , no. 1 (2016) : 27-36
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Nikièma, L., Huybregts, L., Kolsteren, P., Lanou, H., Tiendrebeogo, S., Bouckaert, K., Kouanda, S., Sondo, B., Roberfroid, D.. "Treating moderate acute malnutrition in first-line health services: an effectiveness cluster-randomized trial in Burkina Faso ." The American Journal of Clinical Nutrition 100 , no. 1 (2014) : 241-9
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Behavior change communication (BCC)
  • Locally produced
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Bechman, A., Phillips, R. D., Chen, J.. "The use of nutrient-optimizing/cost-minimizing software to develop ready-to-use therapeutic foods for malnourished pregnant women in Mali ." Food Science & Nutrition 3 , no. 2 (2015) : 110-119
Study Interventions
  • Plant-source protein
  • Locally produced
Research Gaps
  • Cost
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Skau, J. K. H., Bunthang, T., Chamnan, C., Wieringa, F. T., Dijkhuizen, M. A., Roos, N., Ferguson, E. L.. "The use of linear programming to determine whether a formulated complementary food product can ensure adequate nutrients for 6- to 11-month-old Cambodian infants ." The American Journal of Clinical Nutrition 99 , no. 1 (2014) : 130-8
Study Interventions
  • Standard Fortified Food Blends
  • Plant-source protein
  • Locally produced
  • Animal-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Matilsky, D. K., Maleta, K., Castleman, T., Manary, M. J.. "Supplementary feeding with fortified spreads results in higher recovery rates than with a corn/soy blend in moderately wasted children ." The Journal of Nutrition 139 , no. 4 (2009) : 773-778
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Micronutrient powders (MNP)
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Lakkam, M., Wager, S., Wise, P. H., Wein, L. M.. "Quantifying and exploiting the age dependence in the effect of supplementary food for child undernutrition ." PloS One 9 , no. 6 (2014) : e99632
Study Interventions
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Maleta, K. M., Phuka, J., Alho, L., Cheung, Y. B., Dewey,K. G., Ashorn, U., Phiri, N., Phiri, T. E., Vosti, S. A., Zeilani, M., Kumwenda, C., Bendabenda, J., Pulakka, A., Ashorn, P.. "Provision of 10–40 g/d lipid-based nutrient supplements from 6 to 18 months of age does not prevent linear growth faltering in Malawi   ." The Journal of Nutrition 145 , no. 8 (2015) : 1909-15
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Mangani, C., Cheung, Y. B., Maleta, K., Phuka, J., Thakwalakwa, C., Dewey, K., Manary, M., Puumalainen, T., Ashorn, P.. "Providing lipid-based nutrient supplements does not affect developmental milestones among Malawian children ." Acta Paediatrica 103 , no. 1 (2014) : e17-26
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Subramanian, S., Huq, S., Yatsunenko, T., Haque, R., Mahfuz, M., Alam, M. A., Benezra, A., DeStefano, J., Meier, M. F., Muegge, B. D., Barratt, M. J., VanArendonk, L. G., Zhang, Q., Province, M. A., Petri, W. A., Ahmed, T., Gordon, J. I.. "Persistent gut microbiota immaturity in malnourished Bangladeshi children ." Nature 510 , no. 7505 (2014) : 417-21
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Environmental enteric dysfunction (EED)
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Ali, E., Zachariah, R., Shams, Z., Manzi, M., Akter, T., Alders, P., Allaouna, M., Delchevalerie, P., Harries, A. D.. "Peanut-based ready-to-use therapeutic food: How acceptable and tolerated is it among malnourished pregnant and lactating women in Bangladesh? ." Maternal & Child Nutrition 11 , no. 4 (2015) : 1028-1035
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Ali, E., Zachariah, R., Dahmane, A., Van den Boogaard, W., Shams, Z., Akter, T., Alders, P., Manzi, M., Allaouna, M., Draguez, B., Delchevalerie, P., Harries, A. D.. "Peanut-based ready-to-use therapeutic food: acceptability among malnourished children and community workers in Bangladesh ." Public Health Action 3 , no. 2 (2013) : 128-135
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Tang, M., Sheng, X. Y., Krebs, N. F., Hambidge, K. M.. "Meat as complementary food for older breastfed infants and toddlers: a randomized, controlled trial in rural China ." Food and Nutrition Bulletin 35 , no. 4 Suppl (2014) : S188-192
Study Interventions
  • Plant-source protein
  • Locally produced
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Ashorn, U., Alho, L., Arimond, M., Dewey, K. G., Maleta, K., Phiri, N., Phuka, J., Vosti, S. A., Zeilani, M., Ashorn, P.. "Malawian mothers consider lipid-based nutrient supplements acceptable for children throughout a 1-year intervention, but deviation from user recommendations is common ." The Journal of Nutrition 145 , no. 7 (2015) : 1588-1595
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Scherbaum, V., Purwestri, R. C., Stuetz, W., Inayati, D. A., Suryantan, J., Bloem, M. A., Biesalski, H. K.. "Locally produced cereal/nut/legume-based biscuits versus peanut/milk-based spread for treatment of moderately to mildly wasted children in daily programmes on Nias Island, Indonesia: an issue of acceptance and compliance? ." Asia Pacific Journal of Clinical Nutrition 24 , no. 1 (2015) : 152
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Other
  • Behavior change communication (BCC)
  • Animal-source protein
Research Gaps
  • Acceptability
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition