Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 33 Results
Natasha Lelijveld, Claire Godbout, Destiny Krietemeyer, Alyssa Los, Donna Wegner, David T Hendrixson, Robert Bandsma, Aminata Koroma, Mark Manary. "." The American Journal of Clinical Nutrition (2021) : nqab137
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Kristen M Hurley, John Phuka, Yunhee Kang, Julie Ruel-Bergeron, Audrey J Buckland, Maithilee Mitra, Lee Wu, Rolf D W Klemm, Keith P West, Jr., Parul Christian. "." The American Journal of Clinical Nutrition (2021)
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Anastasia Marshak, Helen Young, Anne Radday, Elena N Naumova. "." Maternal & Child Nutrition 17 , no. 2 (2021) : e13103
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Jef L Leroy, Deanna K Olney, Noé Nduwabike, Marie T Ruel. "." The Journal of Nutrition 151 , no. 1 (2021) : 197–205
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Stark, Heather, Anteneh Omer, Aïssata Wereme N'Diaye, Amanda C. Sapp, Emily V. Moore, Sarah L. McKune. "." Maternal & Child Nutrition (2020) : e13069
Study Interventions
  • Behavior change communication (BCC)
  • Locally produced
  • Animal-source protein
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Parul Christian, Kristen M Hurley, John Phuka, Yunhee Kang, Julie Ruel-Bergeron, Audrey J Buckland, Maithilee Mitra, Lee Wu, Rolf Klemm, Keith P West, Jr. "." The Journal of Nutrition (2020)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Gul Nawaz Khan1, MA, MPH ; 2, MPH ; 1, MBBS, FCPS ; 1, MBBS, PhD ; 3, MBBS ; 3, MBBS ; 1, MA ; 4, MA ; 2, BSc ; Alba Cecilia G, Sumra Kureishy, Shabina Ariff, Muhammad Atif Habib, Asra Abeer Usmani, Areeba Mubarik, Masawar Hussain, Naveed Akbar, Pablo Rodriguez de Castro, Alba Cecilia Garzon, Saskia de Pee, Sajid Bashir Soofi. "." JMIR Research Protocols 9 , no. 8 (2020) : p.e19001
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Cash transfer
  • Behavior change communication (BCC)
Research Gaps
  • Cost
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Lieven Huybregts , Agnes Le Port, Elodie Becquey, Amanda Zongrone, Francisco M. Barba, Rahul Rawat, Jef L. Leroy, and Marie T. Ruel. "." PLoS Medicine 16 , no. 8 (2019)
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Elizabeth T Rogawski McQuade, James A Platts-Mills, Jean Gratz, Jixian Zhang, Lawrence H Moulton, Kuda Mutasa, Florence D Majo, Naume Tavengwa, Robert Ntozini, Andrew J Prendergast, Jean H Humphrey, and Jie Liu, Eric R Houpt. "." Journal of Infectious Diseases (2019) : jiz179
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Environmental enteric dysfunction (EED)
  • Behavior change communication (BCC)
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Elodie Becquey, Lieven Huybregts, Amanda Zongrone, Agnes Le Port, Jef L. Leroy, Rahul Rawat, Mariama Touré, Marie T. Ruel. "." PLOS Medicine 16 , no. 8 (2019)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Emanuela Galasso, Ann M Weber, Christine P Stewart, Lisy Ratsifandrihamanana, Lia C H Fernald. "." Lancet Global Health 7 , no. 9 (2019) : 1257-1268
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Deanna K Olney, Jef Leroy, Lilia Bliznashka, and Marie T Ruel. " Background Food-assisted maternal and child health and nutrition (FA-MCHN) programs may foster child growth during the first 1000 d (pregnancy and the first 2 y of a child's life), but evidence is scant. Objective We evaluated the impact of an FA-MCHN program, PROCOMIDA, on linear growth (stunting [length-for-age z score (LAZ) < –2] and length-for-age difference [LAD]) among children aged 1–24 mo. PROCOMIDA was implemented in Guatemala by Mercy Corps and was available to beneficiaries throughout the first 1000 d. Methods We used a longitudinal, cluster-randomized controlled trial with groups varying in family ration sizes [full (FFR), reduced (RFR), and none (NFR)] and individual ration types provided to mothers (pregnancy to 6 mo postpartum) and children (6–24 mo of age) [corn-soy blend (CSB), lipid-based nutrient supplement (LNS), micronutrient powder (MNP)]: 1) FFR + CSB (n = 576); 2) RFR + CSB (n = 575); 3) NFR + CSB (n = 542); 4) FFR + LNS (n = 550); 5) FFR + MNP (n = 587); 6) control (n = 574). Program impacts compared with control, and differential impacts between groups varying family ration size or individual ration type, were assessed through the use of linear mixed-effects models and post hoc simple effect tests (significant if P < 0.05). Results PROCOMIDA significantly reduced stunting at age 1 mo in FFR + CSB, RFR + CSB, and FFR + MNP groups compared with control [5.05, 4.06, and 3.82 percentage points (pp), respectively]. Stunting impact increased by age 24 mo in FFR + CSB and FFR + MNP relative to control (impact = 11.1 and 6.5 pp at age 24 mo, respectively). For CSB recipients, the FFR compared with RFR or NFR significantly reduced stunting (6.47–9.68 pp). CSB reduced stunting significantly more than LNS at age 24 mo (8.12 pp). Conclusions FA-MCHN programs can reduce stunting during the first 1000 d, even in relatively energy/food-secure populations. Large family rations with individual rations of CSB or MNP were most effective. The widening of impact as children age highlights the importance of intervening throughout the full first 1000 d. ." The Journal of Nutrition 148 , no. 9 (2018) : 1493–1505
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Leroy, J. L., Sununtnasuk, C., Heckert, J., Olney, D.. "." FANTA III: Food and Nutrition Technical Assistance Report (2017)
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Wilner, L., Suri, D. J., Langlois, B. K., Walton, S. M., Rogers, B. L.. "." Journal of Health, Population and Nutrition 36 , no. 34 (2017)
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Korenromp, E. L., Adeosun, O., Adegoke, F., Akerele, A., Anger, C., Ohajinwa, C., Hotz, C., Umunna, L., Aminu, F.. "." Public Health Nutrition 19 , no. 10 (2015) : 1882-1892
Study Interventions
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Daly, Z., Northrup-Lyons, M., Reid, R., Cheung, M., Hutchinson, D.. "Effectiveness study for the development of a home fortification programme for young children in Zambia - endline report ." (2017)
Study Interventions
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Locks, L. M., Reerink, I., Tucker Brown, A., Gnegne, S., Ramalanjaona, N., Nanama, S., Duggan, C. P., Garg, A.. "The impact of integrated infant and young child feeding and micronutrient powder intervention on feeding practices and anemia in children aged 6-23 months in Madagascar ." Nutrients 9 , no. 6 (2017)
Study Interventions
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Zhang, Y., Wu, Q., Wang, W., van Velthoven, M. H., Chang, Z., Han, H., Xing, M., Chen, L., Scherpbier, R. W.. "Effectiveness of complementary food supplements and dietary counselling on anaemia and stunting in children aged 6–23 months in poor areas of Qinghai Province, China: a controlled interventional study ." BMJ Open 6 , no. e011234 (2016)
Study Interventions
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Dani, V., Stav, A., Pendharkar, J., Satav, K., Sadanshiv, A., Adhav, A. S., Thakare, B.. "Community-based management of severe malnutrition: SAM and SUW in children under five in the Melghat tribal area, central India ." ENN Field Exchange 52 (2016) : 27
Study Interventions
  • Plant-source protein
  • Behavior change communication (BCC)
  • Locally produced
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Yousafzai, A. K., Obradović, J., Rashee, M. A., Rizvi, A., Portilla, X. A., Tirado-Strayer, N., Siyal, S., Memon, U.. "Effects of responsive stimulation and nutrition interventions on children's development and growth at age 4 years in a disadvantaged population in Pakistan: A longitudinal follow-up of a cluster-randomised factorial effectiveness trial       ." The Lancet Global Health 4 , no. 8 (2016) : e548-e558
Study Interventions
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Nikièma, L., Huybregts, L., Kolsteren, P., Lanou, H., Tiendrebeogo, S., Bouckaert, K., Kouanda, S., Sondo, B., Roberfroid, D.. "Treating moderate acute malnutrition in first-line health services: an effectiveness cluster-randomized trial in Burkina Faso ." The American Journal of Clinical Nutrition 100 , no. 1 (2014) : 241-9
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Behavior change communication (BCC)
  • Locally produced
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Fenn, B., Sangrasi, G. M., Puett, C., Trenouth, L., Pietzsch, S.. "The REFANI Pakistan study-a cluster randomised controlled trial of the effectiveness and cost-effectiveness of cash-based transfer programmes on child nutrition status: study protocol ." BMC Public Health 15 , no. 1 (2015) : 1044
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Cash transfer
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Cost
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Jayson, L., Passarelli, S., Suri, D., Maganga, G., Marcus, S., Webb, P., Rogers, B.. "The price of oil: Behavior change communication and increased oil ration improve mothers' uses of vegetable oil in preparing food aid rations for children in Malawi ." The FASEB Journal 29 , no. 1 Supplement 898.21 (2015)
Study Interventions
  • Behavior change communication (BCC)
  • Standard Fortified Food Blends
  • Other
Research Gaps
  • Innovation
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Leroy, J., Heckert, J., Ruel, M., Cunningham, K.. "Strengthening and evaluating the Preventing Malnutrition in Children under 2 Years of Age approach – Burundi Follow-up Report: Children 0–23 Months ." FANTA III (2014)
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Scherbaum, V., Purwestri, R. C., Stuetz, W., Inayati, D. A., Suryantan, J., Bloem, M. A., Biesalski, H. K.. "Locally produced cereal/nut/legume-based biscuits versus peanut/milk-based spread for treatment of moderately to mildly wasted children in daily programmes on Nias Island, Indonesia: an issue of acceptance and compliance? ." Asia Pacific Journal of Clinical Nutrition 24 , no. 1 (2015) : 152
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Other
  • Behavior change communication (BCC)
  • Animal-source protein
Research Gaps
  • Acceptability
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition