Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 26 Results
Shabina Ariff, Nancy F. Krebs, Sajid Soofi, Jamie Westcott, Zaid Bhatti, Farhana Tabassum, Zulfiqar A. Bhutta. "." The Journal of Nutrition 141 , no. 1 (2014) : 20-26
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Harding, K. L., Matias, S. L., Moniruzzaman, M., Stewart, C. P., Mridha, M. K., Vosti, S. A., Dewey, K. G.. "Rang-Din Nutrition Study: Assessment of participant adherence to lipid-based nutrient and iron-folic acid supplements among pregnant and lactating women in the context of a study on the effectiveness of supplements in Bangladesh ." FANTA III Food and Nutrition Technical Assistance Report (2014)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Owino, V. O., Irena, A. H., Dibari, F., Collins, S.. "Development and acceptability of a novel milk-free soybean-maize-sorghum ready-to-use therapeutic food (SMS-RUTF) based on industrial extrusion cooking process ." Maternal & Child Health 10 , no. 1 (2014) : 126-134
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Locally produced
Research Gaps
  • Acceptability
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Nikièma, L., Huybregts, L., Kolsteren, P., Lanou, H., Tiendrebeogo, S., Bouckaert, K., Kouanda, S., Sondo, B., Roberfroid, D.. "Treating moderate acute malnutrition in first-line health services: an effectiveness cluster-randomized trial in Burkina Faso ." The American Journal of Clinical Nutrition 100 , no. 1 (2014) : 241-9
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Behavior change communication (BCC)
  • Locally produced
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Skau, J. K. H., Bunthang, T., Chamnan, C., Wieringa, F. T., Dijkhuizen, M. A., Roos, N., Ferguson, E. L.. "The use of linear programming to determine whether a formulated complementary food product can ensure adequate nutrients for 6- to 11-month-old Cambodian infants ." The American Journal of Clinical Nutrition 99 , no. 1 (2014) : 130-8
Study Interventions
  • Standard Fortified Food Blends
  • Plant-source protein
  • Locally produced
  • Animal-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Leroy, J., Heckert, J., Ruel, M., Cunningham, K.. "Strengthening and evaluating the Preventing Malnutrition in Children under 2 Years of Age approach – Burundi Follow-up Report: Children 0–23 Months ." FANTA III (2014)
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Lakkam, M., Wager, S., Wise, P. H., Wein, L. M.. "Quantifying and exploiting the age dependence in the effect of supplementary food for child undernutrition ." PloS One 9 , no. 6 (2014) : e99632
Study Interventions
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Mangani, C., Cheung, Y. B., Maleta, K., Phuka, J., Thakwalakwa, C., Dewey, K., Manary, M., Puumalainen, T., Ashorn, P.. "Providing lipid-based nutrient supplements does not affect developmental milestones among Malawian children ." Acta Paediatrica 103 , no. 1 (2014) : e17-26
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Kerac, M., Seal, A.. "Preventing acute malnutrition in young children: Improving the evidence for current and future practice ." PLoS Medicine 11 , no. 9 (2014) : e1001715
Study Interventions
  • Cash transfer
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Subramanian, S., Huq, S., Yatsunenko, T., Haque, R., Mahfuz, M., Alam, M. A., Benezra, A., DeStefano, J., Meier, M. F., Muegge, B. D., Barratt, M. J., VanArendonk, L. G., Zhang, Q., Province, M. A., Petri, W. A., Ahmed, T., Gordon, J. I.. "Persistent gut microbiota immaturity in malnourished Bangladeshi children ." Nature 510 , no. 7505 (2014) : 417-21
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Environmental enteric dysfunction (EED)
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Ray, S.. "Micronutrient supplementation, dietary intervention and resulting body weight gain of severe acute malnourished children–a pilot project study of OJUS Medical Institute ." Indian Journal of Community Health 26 , no. 6 (2014) : 160-165
Study Interventions
  • Micronutrient powders (MNP)
  • Locally produced
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Tang, M., Sheng, X. Y., Krebs, N. F., Hambidge, K. M.. "Meat as complementary food for older breastfed infants and toddlers: a randomized, controlled trial in rural China ." Food and Nutrition Bulletin 35 , no. 4 Suppl (2014) : S188-192
Study Interventions
  • Plant-source protein
  • Locally produced
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Sethuraman, K., Doledec, D., Begum, F., Manir, M. Z.. "Managing acute malnutrition: A review of the evidence and country experiences in South Asia and a recommended approach for Bangladesh ." FANTA Project (2014)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
  • Animal-source protein
Research Gaps
  • Effectiveness
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Iannotti, L. L., Dulience, S. J. L., Green, J., Joseph, S., Francois, J., Antenor, M. L., Lesorogol, C., Mounce, J., Nickerson, N. M.. "Linear growth increased in young children in an urban slum of Haiti: a randomized controlled trial of a lipid-based nutrient supplement ." The American Journal of Clinical Nutrition 99 , no. 1 (2014) : 198-208
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Kerac, M., Bunn, J., Chagaluka, G., Bahwere, P., Tomkins, A., Collins, S., Seal, A.. "Follow-up of post-discharge growth and mortality after treatment for severe acute malnutrition (FuSAM study): a prospective cohort study ." PloS One 9 , no. 6 (2014) : e96030
Study Interventions
  • Other
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Gibbs, M. M., Carriquiry, A. L., Capanzana, M. V., Gibson, R. S.. "Establishing desirable fortificant levels for calcium, iron and zinc in foods for infant and young child feeding: examples from three Asian countries ." Maternal & Child Nutrition 10 , no. 1 (2014) : 112-125
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Amegovu, Andrew Kiri, Ochola, Sophie, Ogwok, Patrick, Yiga, Peter, Musalima, Juliet, Juliana, Mandha. "Efficacy of sorghum peanut blend and corn soy blend plus in the treatment of moderate acute malnutrition in children aged 6–59 months in Karamoja, Uganda: a cluster randomized trial ." Nutrition & Dietary Supplements 6 (2014) : 75-84
Study Interventions
  • Standard Fortified Food Blends
  • Plant-source protein
  • Locally produced
Research Gaps
  • Composition
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
van der Kam, S., Roll, S., Salse, N., Jiya, N. M., Swarthout, T. D., Matsumoto, A., Toyoshima, S., Shanks, L.. "Effectiveness of nutritional supplementation (RUTF and multi micronutrient) in preventing malnutrition and morbidity in children 6-59 months with infection, a randomized control trial in Nigeria  ." MSF Field Research (2014)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Acceptability
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Bahwere, P., Banda, T., Sadler, K., Nyirenda, G., Owino, V., Shaba, B., Dibari, F., Collins, S.. "Effectiveness of milk whey protein-based ready-to-use therapeutic food in treatment of severe acute malnutrition in Malawian under-5 children: a randomised, double-blind, controlled non-inferiority clinical trial ." Maternal & Child Nutrition 10 , no. 3 (2014) : 436-451
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Siega-Riz, A. M., Estrada Del Campo, Y., Kinlaw, A., Reinhart, G. A., Allen, L. H., Shahab-Ferdows, S., Heck, J., Suchindran, C. M., Bentley, M. E.. "Effect of supplementation with a lipid-based nutrient supplement on the micronutrient status of children aged 6-18 months living in the rural region of Intibucá, Honduras ." Paediatric and Perinatal Epidemiology 28 , no. 3 (2014) : 245-254
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Omollo, S. A.. "Effect of improved complementary foods on lean body mass, essential fatty acids, and gross motor development of Kenyan infants ." University of Nairobi Institute of Tropical and Infectious Diseases (2014)
Study Interventions
  • Standard Fortified Food Blends
  • Locally produced
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Lebenthal, Y., Yackobovitch-Gavan, M., Lazar, L., Shalitin, S., Tenenbaum, A., Shamir, R., Phillip, M.. "Effect of a nutritional supplement on growth in short and lean prepubertal children: a prospective, randomized, double-blind, placebo-controlled study ." The Journal of Pediatrics 165 , no. 6 (2014) : 1190-1193.e1
Study Interventions
  • Other
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Ahmed, T., Choudhury, N., Hossain, M. I., Tangsuphoom, N., Islam, M. M., de Pee, S., Steiger, G., Fuli, R., Sarker, S. A. M., Parveen, M., West, K. P., Christian, P.. "Development and acceptability testing of ready-to-use supplementary food made from locally available food ingredients in Bangladesh ." BMC Pediatrics 14 , no. 1 (2014) : 164
Study Interventions
  • Plant-source protein
  • Locally produced
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Ige, O. K., Oladokun, R. E., Kikelomo, O.. "." South African Journal of Child Health 8 , no. 3 (2014) : 104-107
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Portillo-Reyes, V., Pérez-García, M., Loya-Méndez, Y., Puente, A. E.. "Clinical significance of neuropsychological improvement after supplementation with omega-3 in 8–12 years old malnourished Mexican children: A randomized, double-blind, placebo and treatment clinical trial ." Research in Developmental Disabilities 35 , no. 4 (2014) : 861-870
Study Interventions
  • Other
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition