Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 45 Results
Kevin B Stephenson, Sophia E Agapova, Oscar Divala, Yankho Kaimila, Kenneth M Maleta, Chrissie Thakwalakwa, M Isabel Ordiz, Indi Trehan, Mark J Manary. "." American Journal of Clinical Nutrition 106 , no. 6 (2017) : 1500-1507
Study Interventions
  • Standard Fortified Food Blends
  • Environmental enteric dysfunction (EED)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Audrie Lin , Benjamin F Arnold, Andrew N Mertens, Jue Lin, Jade Benjamin-Chung, Shahjahan Ali, Alan E Hubbard, Christine P Stewart, Abul K Shoab, Md Ziaur Rahman, Md Saheen Hossen, Palash Mutsuddi, Syeda L Famida, Salma Akther, Mahbubur Rahman, Leanne Unic. "." eLife 6 (2017)
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Heather C Stobaugh, Lucy B Bollinger, Sara E Adams, Audrey H Crocker, Jennifer B Grise, Julie A Kennedy, Chrissie Thakwalakwa, Kenneth M Maleta, Dennis J Dietzen , Mark J Manary, Indi Trehan. "." The American Journal of Clinical Nutrition 106 , no. 2 (2017) : 657-666
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Christian Fabiansen, Charles W. Yaméogo, Ann-Sophie Iuel-Brockdorf, Bernardette Cichon, Maren J. H. Rytter, Anura Kurpad, Jonathan C. Wells, Christian Ritz, Per Ashorn, Suzanne Filteau, André Briend, Susan Shepherd, Vibeke B. Christensen, Kim F. Michaelsen, Henrik Friis. "." PLoS Medicine 14 , no. 9 (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Elizabeth M. Sloffer, Shashank Gaur, Nicki J. Engeseth, Juan E. Andrade. "." Foods 6 , no. 11 (2017) : 97
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Composition
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Zeweter Abebe , Gulelat Desse Haki, Kaleab Baye. "." Maternal and Child Nutrition 14 , no. 1 (2017)
Study Interventions
  • Standard Fortified Food Blends
  • Other
  • Micronutrient powders (MNP)
Research Gaps
  • Efficacy
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Susan B. Roberts, Maria Angela Franceschini, Amy Krauss, Pei-Yi Lin, Augusto Braima de Sa, Raimundo Co ́, SalimaTaylor, Carrie Brown, Oliver Chen, Elizabeth J. Johnson, William Pruzensky, Nina Schlossman, Carlito Bale ́, Kuan-Cheng (Tony) Wu, Katherine Hagan, Edward Saltzman, Paul Muentener. "." Current Developments in Nutrition 1 , no. 11 (2017)
Study Interventions
  • Standard Fortified Food Blends
  • Micronutrient powders (MNP)
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Humber, J., Vosti, S. A., Cummins, J., Mridha, M., Matias, S. L., Dewey, K.. "The Rang-Din Nutrition Study in rural Bangladesh: the costs and cost-effectiveness of programmatic interventions to improve linear growth at birth and 18 months, and the costs of these interventions at 24 months ." FANTA III Food and Nutrition Technical Assistance Report (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Cost
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Leroy, J. L., Sununtnasuk, C., Heckert, J., Olney, D.. "." FANTA III: Food and Nutrition Technical Assistance Report (2017)
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Wilner, L., Suri, D. J., Langlois, B. K., Walton, S. M., Rogers, B. L.. "." Journal of Health, Population and Nutrition 36 , no. 34 (2017)
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Pulungan, A. B., Mirasanti, D. A.. "Effect of community-based food supplementation on improving growth of underweight children under five years of age in West Nusa Tenggara ." Paediatrica Indonesiana 57 , no. 5 (2017) : 246-251
Study Interventions
  • Other
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Schlossman, N., Brown, C., Batra, P., Braima de Sa, A., Balan, I., Balan, A., Gamache, M. G., Wood, L., Pruzensky, W., Saltzman, E., Roberts, S. B., Bale, C.. "A randomized controlled trial of two ready-to-use supplementary foods demonstrates benefit of the higher dairy supplement for reduced wasting in mothers, and differential impact in infants and children associated with maternal supplement response ." Food and Nutrition Bulletin 38 , no. 3 (2017) : 275-290
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Callaghan-Gillespie, M., Schaffner, A. A., Garcia, P., Fry, J., Eckert, R. , Malek, S., Trehan, I., Thakwalakwa, C., Maleta, K. M., Manary, M. J., Papathakis, P. C.. "Trial of ready-to-use supplemental food and corn-soy blend in pregnant Malawian women with moderate malnutrition: a randomized controlled clinical trial ." American Journal of Clinical Nutrition 106 , no. 4 (2017) : 1062-1069
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Akparibo, R., Harris, J., Blank, L., Campbell, M. J., Holdsworth, M.. "Severe acute malnutrition in children aged under 5 years can be successfully managed in a non-emergency routine community healthcare setting in Ghana ." Maternal & Child Nutrition 13 , no. 4 (2017) : e12417
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Adams, A. M., Ahmed, R., Mahbub Latif, A. H. M., Rasheed, S., Das, S. K., Hasib, E., Farzana, F. D., Ferdous, F., Ahmed, S., Faruque, A. S. G.. "Impact of fortified biscuits on micronutrient deficiencies among primary school children in Bangladesh ." PLoS One (2017)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Adu-Afarwuah, S., Lartey, A., Okronipa, H., Ashorn, P., Zeilani, M., Oaks, B. M., Baldiviez, L. M., Vosti, S., Dewey, K. G.. "Impact of small-quantity lipid-based nutrient supplement on hemoglobin, iron status and biomarkers of inflammation in pregnant Ghanaian women ." Maternal & Child Nutrition 13 , no. 2 (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Lanyero, B., Namusoke, H., Nabukeera-Barungi, N., Grenov, B., Mupere, E., Michaelsen, K. F., Molgaard, C., Christensen, V. B., Friis, H., Briend, A.. "Transition from F-75 to ready-to-use therapeutic food in children with severe acute malnutrition, an observational study in Uganda ." Nutrition Journal 16 , no. 1 (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Unger, S. A., Drammeh, S., Hasan, J., Ceesay, K., Sinjanka, E., Beyai, S., Sonko, B., Dondeh, B. L., Filford, A. J., Moore, S. E., Prentice, A. M.. "Impact of fortified versus unfortified lipid-based supplements on morbidity and nutritional status: A randomised double-blind placebo-controlled trial in ill Gambian children ." PLoS Medicine 14 , no. 8 (2017) : e1002377
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Kampstra, N. A., Van Hoan, N., Koenders, D. J. P. C., Schoop, R., Broersen, C. B., Mouquet-Rivier, C., Traore, T., Bruins, M. J., de Pee, S.. "Energy and nutrient intake increased by 47–67% when amylase was added to fortified blended foods—a study among 12- to 35-month-old Burkinabe children ." Maternal & Child Nutrition (2017)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Delimont, N. M., Alavi, S., Lindshield, B.. "New formulations for fortified-blended foods: the MFFAPP Tanzania efficacy trial ." The FASEB Journal 31 , no. 1 (2017) : Supplement 786.15
Study Interventions
  • Standard Fortified Food Blends
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Bahwere, P., Akomo, P., Mwale, M., Murakami, H., Banda, C., Kathumba, S., Banda, C., Jere, S., Sadler, K., Collins, S.. "." American Journal of Clinical Nutrition (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Sulistiyono, P., Herawati, D. M. D., Arya, I. F. D.. "Rebon shrimp powder addition influence to nutritional values, organoleptic properties and acceptance of supplementary food by children aged 4-5 years old ." Kesmas: National Public Health Journal 11 , no. 4 (2017) : 168-172
Study Interventions
  • Locally produced
  • Animal-source protein
Research Gaps
  • Acceptability
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Isanka, S., Kodish, S. R., Berthe, F., Alley, I., Nackers, F., Hanson, K. E., Grais, R. F.. "Outpatient treatment of severe acute malnutrition: response to treatment with a reduced schedule of therapeutic food distribution ." The American Journal of Clinical Nutrition (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Manary, M., Callaghan, M., Wegner, D., Papathakis, P.. "Randomized controlled trial of the impact of treating moderately malnourished women in pregnancy ." (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Mehta, R., Platt, A. C., Sun, X., Desai, M., Clements, D., Turner, E. L.. "Efficacy of iron-supplement bars to reduce anemia in urban Indian women: a cluster-randomized controlled trial ." The American Journal of Clinical Nutrition (2017)
Study Interventions
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight