Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 51 - 75 of 334 Results
R. B. Kajjura, F. J. Veldman, S. M. Kassier. "." Journal of Human Nutrition and Dietetics 32 , no. 3 (2019) : 295–302
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Sarah J Zyba, Rita Wegmüller, Leslie R Woodhouse, Kabiru Ceesay, Andrew M Prentice, Kenneth H Brown, and K Ryan Wessells. "." The American Journal of Clinical Nutrition 110 , no. 6 (2019) : 1465–1475
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Elodie Becquey, Lieven Huybregts, Amanda Zongrone, Agnes Le Port, Jef L. Leroy, Rahul Rawat, Mariama Touré, Marie T. Ruel. "." PLOS Medicine 16 , no. 8 (2019)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Emanuela Galasso, Ann M Weber, Christine P Stewart, Lisy Ratsifandrihamanana, Lia C H Fernald. "." Lancet Global Health 7 , no. 9 (2019) : 1257-1268
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Behavior change communication (BCC)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Peter Akomo, Paluku Bahwere, Hitoshi Murakami, Chrissy Banda, Elizabeth Maganga, Sylvester Kathumba, Kate Sadler, Steve Collins . "." BMC Public Health 19 , no. 1 (2019)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
M Isabel Ordiz, Richard D Semba, Ruin Moaddel, Ulrike Rolle-Kampczyk, Martin von Bergen, Gunda Herberth, Mohammed Khadeer, Stefan Röder, Mark J Manary. "." Current Developments in Nutrition 3 , no. 10 (2019)
Study Interventions
  • Standard Fortified Food Blends
  • Plant-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Mangani C, Maleta K, Phuka J, Cheung YB, Thakwalakwa C, Dewey K, Manary M, Puumalainen T, Ashorn P.. "." Maternal & Child Nutrition 11 , no. S4 (2015) : 132-143
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Cornelius M Smuts, Tonderayi M Matsungo, Linda Malan, Herculina S Kruger, Marinel Rothman, Jane D Kvalsvig, Namukolo Covic, Karen Joosten, Saskia J M Osendarp, Maaike J Bruins, Leon G J Frenken, Carl J Lombard, Mieke Faber. "." The American Journal of Clinical Nutrition 109 , no. 1 (2019) : 55-68
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Julie M Long, Prasenjit Mondal, Jamie E Westcott, Leland V Miller, M Munirul Islam, Mondar Ahmed, Mustafa Mahfuz, Tahmeed Ahmed, Nancy F Krebs.. "." Journal of Nutrition 149 , no. 1 (2019) : 98–105
Study Interventions
  • Standard Fortified Food Blends
  • Environmental enteric dysfunction (EED)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Md. Iqbal Hossain, Sayeeda Huq, M. Munirul Islam, Tahmeed Ahmed.. "." European Journal of Nutrition (2019)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Gladstone MJ, Chandna J, Kandawasvika G, Ntozini R, Majo FD, Tavengwa NV, Mbuya MNN, Mangwadu GT, Chigumira A, Chasokela CM, Moulton LH, Stoltzfus RJ, Humphrey JH, Prendergast AJ; SHINE Trial Team.. "." PLoS Medicine 16 , no. 3 (2019)
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Humphrey JH, Mbuya MNN, Ntozini R, Moulton LH, Stoltzfus RJ, Tavengwa NV, Mutasa K, Majo F, Mutasa B, Mangwadu G, Chasokela CM, Chigumira A, Chasekwa B, Smith LE, Tielsch JM, Jones AD, Manges AR, Maluccio JA, Prendergast AJ; SHINE Team. "." Lancet Global Health 7 , no. 1 (2019) : e132-e147
Study Interventions
  • Water, sanitation, hygiene (WASH)
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Delimont NM, Vahl CI, Kayanda R, Msuya W, Mulford M, Alberghine P, Praygod G, Mngara J, Alavi S, Lindshield BL. "." Current Developments in Nutrition 3 , no. 6 (2019)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Shen Y, Griswold S, Langlois B, Suri D, Vosti S, Webb P, Rogers B.. "." Current Developments in Nutrition 3 , no. Supp 1 (2019) : P10-142-19
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Cost
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Shen Y, Griswold S, Langlois B, Suri D, Vosti S, Webb P, Rogers B.. "." Current Developments in Nutrition 3 , no. Supp 1 (2019) : P10-140-19
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Harriet Okronipa, Mary Arimond, Charles D Arnold, Rebecca R Young, Seth Adu-Afarwuah, Solace M Tamakloe, Maku E Ocansey, Sika M Kumordzie, Brietta M Oaks, Julie A Mennella, and Kathryn G Dewey.. "." American Journal of Clinical Nutrition 109 , no. 4 (2019) : 1224–1232
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Sika M Kumordzie, Seth Adu-Afarwuah, Mary Arimond, Rebecca R Young, Theodosia Adom, Rose Boatin, Maku E Ocansey, Harriet Okronipa, Elizabeth L Prado, Brietta M Oaks, and Kathryn G Dewey.. "." The Journal of Nutrition 149 , no. 5 (2019) : 847–855
Study Interventions
  • Standard Fortified Food Blends
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Jef L Leroy, Deanna Olney, Marie Ruel. "." The Journal of Nutrition 148 , no. 3 (2018) : 445–452
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Maku E Ocansey, Seth Adu-Afarwuah, Sika M Kumordzie, Harriet Okronipa, Rebecca R Young, Solace M Tamakloe, Brietta M Oaks, Kathryn G Dewey, and Elizabeth L Prado. "." The American Journal of Clinical Nutrition 109 , no. 2 (2019) : 322–334
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Briony Stevens, Kerrianne Watt, Julie Brimbecombe, Alan Clough, Jenni A. Judd, and Daniel Lindsay. "   ." BMC Pregnancy & Childbirth 18 (2018) : 286
Study Interventions
  • Standard Fortified Food Blends
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Cambria M. Glosz, Andrew A. Schaffner, Scott K. Reaves, Mark J. Manary, and Peggy C. Papathakis. "." Nutrients 10 , no. 7 (2018) : 879
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
  • Treatment of Severe Acute Malnutrition
Sigh S, Roos N, Sok D, Borg B, Chamnan C, Laillou A, Dijkhuizen MA, Wieringa FT.. "." Food and Nutrition Bulletin 39 , no. 8 (2018)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Wataru Sato, Chie Furuta, Keiko Matsunaga, Paluku Bahwere, Steve Collins, Kate Sadler, Peter Akomo, Chrissy Banda, Elizabeth Maganga, Sylvester Kathumba, Hitoshi Murakami. "." PLoS One 13 , no. 8 (2018)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Deanna K Olney, Jef Leroy, Lilia Bliznashka, and Marie T Ruel. " Background Food-assisted maternal and child health and nutrition (FA-MCHN) programs may foster child growth during the first 1000 d (pregnancy and the first 2 y of a child's life), but evidence is scant. Objective We evaluated the impact of an FA-MCHN program, PROCOMIDA, on linear growth (stunting [length-for-age z score (LAZ) < –2] and length-for-age difference [LAD]) among children aged 1–24 mo. PROCOMIDA was implemented in Guatemala by Mercy Corps and was available to beneficiaries throughout the first 1000 d. Methods We used a longitudinal, cluster-randomized controlled trial with groups varying in family ration sizes [full (FFR), reduced (RFR), and none (NFR)] and individual ration types provided to mothers (pregnancy to 6 mo postpartum) and children (6–24 mo of age) [corn-soy blend (CSB), lipid-based nutrient supplement (LNS), micronutrient powder (MNP)]: 1) FFR + CSB (n = 576); 2) RFR + CSB (n = 575); 3) NFR + CSB (n = 542); 4) FFR + LNS (n = 550); 5) FFR + MNP (n = 587); 6) control (n = 574). Program impacts compared with control, and differential impacts between groups varying family ration size or individual ration type, were assessed through the use of linear mixed-effects models and post hoc simple effect tests (significant if P < 0.05). Results PROCOMIDA significantly reduced stunting at age 1 mo in FFR + CSB, RFR + CSB, and FFR + MNP groups compared with control [5.05, 4.06, and 3.82 percentage points (pp), respectively]. Stunting impact increased by age 24 mo in FFR + CSB and FFR + MNP relative to control (impact = 11.1 and 6.5 pp at age 24 mo, respectively). For CSB recipients, the FFR compared with RFR or NFR significantly reduced stunting (6.47–9.68 pp). CSB reduced stunting significantly more than LNS at age 24 mo (8.12 pp). Conclusions FA-MCHN programs can reduce stunting during the first 1000 d, even in relatively energy/food-secure populations. Large family rations with individual rations of CSB or MNP were most effective. The widening of impact as children age highlights the importance of intervening throughout the full first 1000 d. ." The Journal of Nutrition 148 , no. 9 (2018) : 1493–1505
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Bindi Borg, Seema Mihrshahi, Mark Griffin, Daream Sok, Chamnan Chhoun, Arnaud Laillou, Frank T. Wieringa. "." Maternal & Child Nutrition 15 , no. 3 (2019)
Study Interventions
  • Standard Fortified Food Blends
  • Locally produced
Research Gaps
  • Acceptability
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition