Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 151 - 175 of 328 Results
Dewey, K. G., Mridha, M. K., Matias, S. L., Arnold, C. D., Cummins, J. R., Khan, M. S. A., Maalouf-Manasseh, Z., Siddiqui, Z., Ullah, B. "Lipid-based nutrient supplementation in the first 1000 d improves child growth in Bangladesh: a cluster-randomized effectiveness trial ." The American Journal of Clinical Nutrition (2017)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Isanka, S., Menzies, N. A., Sayyad, J., Ayoola, M., Grais, R. F., Doyon, S.. "Cost analysis of the treatment of severe acute malnutrition in West Africa ." Maternal & Child Nutrition (2016)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Animal-source protein
Research Gaps
  • Cost
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Zhang, Y., Wu, Q., Wang, W., van Velthoven, M. H., Chang, Z., Han, H., Xing, M., Chen, L., Scherpbier, R. W.. "Effectiveness of complementary food supplements and dietary counselling on anaemia and stunting in children aged 6–23 months in poor areas of Qinghai Province, China: a controlled interventional study ." BMJ Open 6 , no. e011234 (2016)
Study Interventions
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Wang, A. Z., Shulman, R. J., Crocker, A. H., Thakwalakwa, C., Maleta, K. M., Devaraj, S., Manary, M., Trehan, I.. "A combined intervention of zinc, multiple micronutrients, and Albendazole does not ameliorate environmental enteric dysfunction or stunting in rural Malawian children in a double-blind randomized controlled trial ." The Journal of Nutrition 147 , no. 1 (2017) : 97-103
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Jie, C.. "Improve nutrition, food safety, and food security for China’s most vulnerable women and children – Joint final evaluation ." International Labor Office - Evaluation Unit (2013)
Study Interventions
  • Micronutrient powders (MNP)
  • Plant-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Dani, V., Stav, A., Pendharkar, J., Satav, K., Sadanshiv, A., Adhav, A. S., Thakare, B.. "Community-based management of severe malnutrition: SAM and SUW in children under five in the Melghat tribal area, central India ." ENN Field Exchange 52 (2016) : 27
Study Interventions
  • Plant-source protein
  • Behavior change communication (BCC)
  • Locally produced
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Oaks, B. M., Young, R. R., Adu-Afarwuah, S., Ashorn, U., Jackson, K. H., Lartey, A., Maleta, K., Okronipa, H., Sadalaki, J., Baldiviez, L. M., Shahab-Ferdows, S., Ashorn, P., Dewey, K. G.. "Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials ." Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) 117 (2017) : 28-35
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Rogers, B. L., Wilner, L., Maganga, G., Walton, S., Suri, D. J., Langlois, B., Chui, K. K. H., Boiteau, J., Vosti, S., Webb, P.. "Program changes are effective and cost-effective in increasing the amount of oil used in preparing corn soy blend porridge for treatment of moderate acute malnutrition in Malawi ." Maternal & Child Nutrition (2017)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Cost
  • Efficacy
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Iuel-Brockdorf, A., Ouedraogo, A., Ritz, C., Draebel, T. A., Ashorn, P., Filteau, S., Michaelsen, K. F.. "Feeding behaviors during home-based treatment of moderate acute malnutrition using corn-soy blends or lipid-based nutrient supplements ." Maternal & Child Nutrition (2016)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Nisbett, N., Longhurst, R., Barnett, I., Feruglio, F., Gordon, J., Hoddinott, J., Jahan, F., Karachiwalla, N., Roy, S., Shah, V., Siddiki, O. F., Tranchant, J. P., White, J.. "Impact evaluation of the DFID Programme to accelerate improved nutrition for the extreme poor in Bangladesh: Final Report ." DFID (2016)
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Moramarco, S., Amerio, G., Ciarlantini, C., Chipoma, J. K., Simpungwe, M. K., Nielsen-Saines, K., Palombi, L., Buonomo, E.. "Community-based management of child malnutrition in Zambia: HIV/AIDS infection and other risk factors on child survival ." International Journal of Environmental Research and Public Health 13 , no. 7 (2016) : 666
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Kumwenda, G., Nhlema, B., Maganga, G., Rogers, B., Walton, S., Boiteau, J., Webb, P.. "Feasibility and acceptability study of preparing corn soy blend with fortified vegetable oil in Malawi: Formative research ." USAID Food Aid Quality Review (2016)
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Bailey, J., Chase, R., Kerac, M., Briend, A., Manary, M., Opondo, C., Gallagher, M., Kim, A.. "Combined protocol for SAM/MAM treatment: The ComPAS study ." ENN Online Field Exchange No. 53 (2016)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Irena, A., Bahwere, P., Owino, V., Diop, E. I., Bachmann, M., Mbwili-Muleya, C., Dibari, F., Sadler, K., Collins, S.. "      ." Maternal & Child Nutrition 11 , no. S4 (2015) : 105-119
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Cost
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Koroma, A., Manary, M., Marron, B., Green, J., Rogers, B., Walton, S., Chui, K. H. K., Suri, D., Langlois, B., Jayson, L., Boiteau, J., Rosenberg, I., de Pee, S., Vosti, S., Webb, P.. "Comparison of four supplementary foods in treating moderate acute malnutrition in Sierra Leone: an Ebola-constrained cluster-randomized, controlled clinic-based effectiveness trial: A Report from the Food Aid Quality Review ." (2015)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Cost
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Yousafzai, A. K., Obradović, J., Rashee, M. A., Rizvi, A., Portilla, X. A., Tirado-Strayer, N., Siyal, S., Memon, U.. "Effects of responsive stimulation and nutrition interventions on children's development and growth at age 4 years in a disadvantaged population in Pakistan: A longitudinal follow-up of a cluster-randomised factorial effectiveness trial       ." The Lancet Global Health 4 , no. 8 (2016) : e548-e558
Study Interventions
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Thakwalakwa, C. M., Ashorn, P., Phuka, J. C., Cheung, Y. B., Briend, A., Maleta, K. M.. "Impact of lipid-based nutrient supplements and corn-soy blend on energy and nutrient intake among moderately underweight 8-18-month-old children participating in a clinical trial.  ." Maternal & Child Nutrition 11 , no. S4 (2015) : 144-150
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Rahman, A. S., Ahmed, T., Ahmed, F., Alam, M. S., Wahed, M. A., Sack, D. A.. "Double-blind cluster randomised controlled trial of wheat flour chapatti fortified with micronutrients on the status of vitamin A and iron in school-aged children in rural Bangladesh ." Maternal & Child Nutrition 11 , no. S4 (2015) : 120-131
Study Interventions
  • Micronutrient powders (MNP)
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Owino, V. O., Irena, A. H., Dibari, F., Collins, S.. "Development and acceptability of a novel milk-free soybean-maize-sorghum ready-to-use therapeutic food (SMS-RUTF) based on industrial extrusion cooking process ." Maternal & Child Health 10 , no. 1 (2014) : 126-134
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Locally produced
Research Gaps
  • Acceptability
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Osei, A. K., Pandey, P., Spiro, D., Adhikari, D., Haselow, N., De Morais, C., Davis, D.. "Adding multiple micronutrient powders to a homestead food production programme yields marginally significant benefit on anaemia reduction among young children in Nepal ." Maternal & Child Health 11 , no. S4 (2015) : 188-202
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Leyvraz, M., Rohner, F., Konan, A. G., Esso, L. J. C. E., Woodruff, B. A., Norte, A., Adiko, A. F., Bonfoh, B., Aaron, G. J.. "High awareness but low coverage of a locally produced fortified complementary food in Abidjan, Côte d’Ivoire: Findings from a cross-sectional survey ." PLoS ONE 11 , no. 11 (2016) : e0166295
Study Interventions
  • Locally produced
Research Gaps
  • Innovation
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Lesorogol, C., Jean-Louis, S., Green, J., Iannotti, L. . "Preventative lipid-based nutrient supplements (LNS) and young child feeding practices: findings from qualitative research in Haiti ." Maternal & Child Nutrition 11 , no. S4 (2015) : 62-76
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Leroy, J. L., Olney, D. K., Ruel, M. T.. "Tubaramure, a food-assisted integrated health and nutrition program in Burundi, increases maternal and child hemoglobin concentrations and reduces anemia: A theory-based cluster-randomized controlled intervention trial  ." Journal of Nutrition 146 , no. 8 (2016) : 1601-1608
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Klevor, M. K., Adu-Afarwuah, S., Ashorn, P., Arimond, M., Dewey, K. G., Lartey, A., Maleta, K., Phiri, N., Pyykko, J., Zeilani, M., Ashorn, U.. "A mixed method study exploring adherence to and acceptability of small quantity lipid-based nutrient supplements (SQ-LNS) among pregnant and lactating women in Ghana and Malawi ." BMC Pregnancy and Childbirth 16 , no. 1 (2016) : 253
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Flax, V. L., Siega-Riz, A. M., Reinhart, G. A., Bentley, M. E.. "Provision of lipid-based nutrient supplements to Honduran children increases their dietary macro- and micronutrient intake without displacing other foods. ." Maternal & Child Nutrition 11 , no. S4 (2015) : 203-213
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight