Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 176 - 200 of 337 Results
Thakwalakwa, C. M., Ashorn, P., Phuka, J. C., Cheung, Y. B., Briend, A., Maleta, K. M.. "Impact of lipid-based nutrient supplements and corn-soy blend on energy and nutrient intake among moderately underweight 8-18-month-old children participating in a clinical trial.  ." Maternal & Child Nutrition 11 , no. S4 (2015) : 144-150
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Rahman, A. S., Ahmed, T., Ahmed, F., Alam, M. S., Wahed, M. A., Sack, D. A.. "Double-blind cluster randomised controlled trial of wheat flour chapatti fortified with micronutrients on the status of vitamin A and iron in school-aged children in rural Bangladesh ." Maternal & Child Nutrition 11 , no. S4 (2015) : 120-131
Study Interventions
  • Micronutrient powders (MNP)
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Owino, V. O., Irena, A. H., Dibari, F., Collins, S.. "Development and acceptability of a novel milk-free soybean-maize-sorghum ready-to-use therapeutic food (SMS-RUTF) based on industrial extrusion cooking process ." Maternal & Child Health 10 , no. 1 (2014) : 126-134
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Locally produced
Research Gaps
  • Acceptability
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Osei, A. K., Pandey, P., Spiro, D., Adhikari, D., Haselow, N., De Morais, C., Davis, D.. "Adding multiple micronutrient powders to a homestead food production programme yields marginally significant benefit on anaemia reduction among young children in Nepal ." Maternal & Child Health 11 , no. S4 (2015) : 188-202
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Leyvraz, M., Rohner, F., Konan, A. G., Esso, L. J. C. E., Woodruff, B. A., Norte, A., Adiko, A. F., Bonfoh, B., Aaron, G. J.. "High awareness but low coverage of a locally produced fortified complementary food in Abidjan, Côte d’Ivoire: Findings from a cross-sectional survey ." PLoS ONE 11 , no. 11 (2016) : e0166295
Study Interventions
  • Locally produced
Research Gaps
  • Innovation
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Lesorogol, C., Jean-Louis, S., Green, J., Iannotti, L. . "Preventative lipid-based nutrient supplements (LNS) and young child feeding practices: findings from qualitative research in Haiti ." Maternal & Child Nutrition 11 , no. S4 (2015) : 62-76
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Leroy, J. L., Olney, D. K., Ruel, M. T.. "Tubaramure, a food-assisted integrated health and nutrition program in Burundi, increases maternal and child hemoglobin concentrations and reduces anemia: A theory-based cluster-randomized controlled intervention trial  ." Journal of Nutrition 146 , no. 8 (2016) : 1601-1608
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Klevor, M. K., Adu-Afarwuah, S., Ashorn, P., Arimond, M., Dewey, K. G., Lartey, A., Maleta, K., Phiri, N., Pyykko, J., Zeilani, M., Ashorn, U.. "A mixed method study exploring adherence to and acceptability of small quantity lipid-based nutrient supplements (SQ-LNS) among pregnant and lactating women in Ghana and Malawi ." BMC Pregnancy and Childbirth 16 , no. 1 (2016) : 253
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Flax, V. L., Siega-Riz, A. M., Reinhart, G. A., Bentley, M. E.. "Provision of lipid-based nutrient supplements to Honduran children increases their dietary macro- and micronutrient intake without displacing other foods. ." Maternal & Child Nutrition 11 , no. S4 (2015) : 203-213
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Choudhury, N., Bromage, S., Alam, M. A., Shamsir Ahmed, A. M., Munirul Islam, M., Iqbal Hossain, M., Mahfuz, M., Mondal, D., Ahmed, T.. "Intervention study shows suboptimal growth among children receiving a food supplement for five months in a slum in Bangladesh ." Acta Paediatrica 105 , no. 10 (2016) : e464-e473
Study Interventions
  • Standard Fortified Food Blends
  • Micronutrient powders (MNP)
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Chavasit, V., Porasuphatana, S., Suthutvoravut, U., Zeder, C., Hurrell, R.. "Iron bioavailability in 8-24-month-old Thai children from a micronutrient-fortified quick-cooking rice containing ferric ammonium citrate or a mixture of ferrous sulphate and ferric sodium ethylenediaminetetraacetic acid ." Maternal & Child Nutrition 11 , no. S4 (2015) : 179-187
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Cames, C., Varloteaux, M., Have, N. N., Diom, A. B.,, Msellati, P., Mbaye, N., Mbodji, H., Sy Signate, H., Diack, A., ANRS 12279 MAGGSEN Cohort Study. "Acceptability of outpatient ready-to-use food-based protocols in HIV-infected Senegalese children and adolescents within the MAGGSEN cohort study   ." Food and Nutrition Bulletin 38 , no. 1 (2016) : 27-36
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Barth-Jaeggi, T., Moretti, D., Kvalsvig, J., Holding, P. A., Njenga, J., Mwangi, A., Chhaga, M. K., Lacroix, C., Zimmermann, M. B.. "In-home fortification with 2.5 mg iron as NaFeEDTA does not reduce anaemia but increases weight gain: a randomised controlled trial in Kenyan infants ." Maternal & Child Nutrition 11 , no. S4 (2015) : 151-162
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Arimond, M., Zeilani, M., Jungjohann, S., Brown, K. H., Ashorn, P., Allen, L. H., Dewey, K. G.. "Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS) Project ." Maternal & Child Nutrition 11 , no. S4 (2015) : 31-61
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Abbeddou, S., Hess, S. Y., Yakes Jimenez, E., Somé, J. W., Vosti, S. A., Guissou, R. M., Ouedragogo, J. B., Brown, K. H.. "Comparison of methods to assess adherence to small-quantity lipid-based nutrient supplements (SQ-LNS) and dispersible tablets among young Burkinabé children participating in a community-based intervention trial ." Maternal & Child Nutrition 11 , no. S4 (2015) : 90-104
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Segrè, J., Winnard, K., Abrha, T. H., Abebe, Y., Shilane, D., Lapping, K.. "Willingness to pay for lipid‐based nutrient supplements for young children in four urban sites of Ethiopia ." Maternal & Child Nutrition 11 , no. Suppl 4 (2013) : 16-30
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Abizari, A., Moretti, D., Zimmermann, M. B., Armar-Klemesu, M., Brouwer, I. D.. "Whole cowpea meal fortified with NaFeEDTA reduces iron deficiency among Ghanaian school children in a malaria endemic area ." The Journal of Nutrition 142 , no. 10 (2012) : 1836-1842
Study Interventions
  • Standard Fortified Food Blends
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Karakochuk, C., van den Briel, T., Stephens, D., Zlotkin, S.. "Treatment of moderate acute malnutrition with ready-to-use supplementary food results in higher overall recovery rates compared with a corn-soya blend in children in southern Ethiopia: an operations research trial ." The American Journal of Clinical Nutrition 96 , no. 4 (2012) : 911-6
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Nikièma, L., Huybregts, L., Kolsteren, P., Lanou, H., Tiendrebeogo, S., Bouckaert, K., Kouanda, S., Sondo, B., Roberfroid, D.. "Treating moderate acute malnutrition in first-line health services: an effectiveness cluster-randomized trial in Burkina Faso ." The American Journal of Clinical Nutrition 100 , no. 1 (2014) : 241-9
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Behavior change communication (BCC)
  • Locally produced
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Bechman, A., Phillips, R. D., Chen, J.. "The use of nutrient-optimizing/cost-minimizing software to develop ready-to-use therapeutic foods for malnourished pregnant women in Mali ." Food Science & Nutrition 3 , no. 2 (2015) : 110-119
Study Interventions
  • Plant-source protein
  • Locally produced
Research Gaps
  • Cost
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Skau, J. K. H., Bunthang, T., Chamnan, C., Wieringa, F. T., Dijkhuizen, M. A., Roos, N., Ferguson, E. L.. "The use of linear programming to determine whether a formulated complementary food product can ensure adequate nutrients for 6- to 11-month-old Cambodian infants ." The American Journal of Clinical Nutrition 99 , no. 1 (2014) : 130-8
Study Interventions
  • Standard Fortified Food Blends
  • Plant-source protein
  • Locally produced
  • Animal-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Fenn, B., Sangrasi, G. M., Puett, C., Trenouth, L., Pietzsch, S.. "The REFANI Pakistan study-a cluster randomised controlled trial of the effectiveness and cost-effectiveness of cash-based transfer programmes on child nutrition status: study protocol ." BMC Public Health 15 , no. 1 (2015) : 1044
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Cash transfer
  • Behavior change communication (BCC)
  • Micronutrient powders (MNP)
Research Gaps
  • Cost
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Jayson, L., Passarelli, S., Suri, D., Maganga, G., Marcus, S., Webb, P., Rogers, B.. "The price of oil: Behavior change communication and increased oil ration improve mothers' uses of vegetable oil in preparing food aid rations for children in Malawi ." The FASEB Journal 29 , no. 1 Supplement 898.21 (2015)
Study Interventions
  • Behavior change communication (BCC)
  • Standard Fortified Food Blends
  • Other
Research Gaps
  • Innovation
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Tonguet-Papucci, A., Huybregts, L., Aissa, M. A.. "The MAM'Out project: a randomized controlled trial to assess multiannual and seasonal cash transfers for the prevention of acute malnutrition in children ." BMC Public Health (2015)
Study Interventions
  • Cash transfer
Research Gaps
  • Cost
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Steenkamp, L., Lategan, R., Raubenheimer, J.. "The impact of Ready-to-Use Supplementary Food (RUSF) in targeted supplementation of children with moderate acute malnutrition (MAM) in South Africa ." South African Family Practice 57 , no. 5 (2015) : 322-325
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition