Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 201 - 225 of 337 Results
Ashorn, P., Alho, L., Ashorn, U., Cheung, Y. B., Dewey, K. G., Harjunmaa, U., Lartey, A., Nkhoma, M., Phiri, N., Phuka, J., Vosti, S. A., Zeilani, M., Maleta, K.. "The impact of lipid-based nutrient supplement provision to pregnant women on newborn size in rural Malawi: a randomized controlled trial ." The American Journal of Clinical Nutrition 101 , no. 2 (2015) : 387-97
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Zimmermann, M. B., Chassard, C., Rohner, F., N'Goran, E. K., Nindjin, C., Dostal, A., Utzinger, J., Ghattas, H., Lacroix, C., Hurrell, R. F.. "The effects of iron fortification on the gut microbiota in African children: a randomized controlled trial in Cote d'Ivoire ." American Journal of Clinical Nutrition 92 , no. 6 (2010) : 1406-1415
Study Interventions
  • Standard Fortified Food Blends
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Huybregts, L., Houngbé, F., Salpéteur, C., Brown, R., Roberfroid, D., Ait-Aissa, M., Kolsteren, P.. "The effect of adding ready-to-use supplementary food to a general food distribution on child nutritional status and morbidity: a cluster-randomized controlled trial ." PLoS Medicine 9 , no. 9 (2012) : e1001313
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Ashorn, P., Alho, L., Ashorn, U., Cheung, Y. B., Dewey, K. G., Gondwe, A., Harjunmaa, U., Lartey, A., Phiri, N., Phiri, T. E., Vosti, S. A., Zeilani, M., Maleta, K.. "Supplementation of maternal diets during pregnancy and for 6 months postpartum and infant diets thereafter with small-quantity lipid-based nutrient supplements does not promote child growth by 18 months of age in rural Malawi: A randomized controlled trial ." The Journal of Nutrition 145 , no. 6 (2015) : 1345-53
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Purwestri, R. C., Scherbaum, V., Inayati, D. A., Wirawan, N. N., Suryantan, J., Bloem, M. A., Pangaribuan, R. V., Stuetz, W., Hoffmann, V., Qaim, M., Biesalski, H. K., Bellows, A. C.. "Supplementary feeding with locally-produced ready-to-use food (RUF) for mildly wasted children on Nias island, Indonesia: Comparison of daily and weekly program outcomes ." Asia Pacific Journal of Clinical Nutrition 21 , no. 3 (2012) : 374
Study Interventions
  • Locally produced
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Matilsky, D. K., Maleta, K., Castleman, T., Manary, M. J.. "Supplementary feeding with fortified spreads results in higher recovery rates than with a corn/soy blend in moderately wasted children ." The Journal of Nutrition 139 , no. 4 (2009) : 773-778
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Micronutrient powders (MNP)
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Phuka, J., Thakwalakwa, C., Maleta, K., Cheung, Y. B., Briend, A., Manary, M., Ashorn, P.. "Supplementary feeding with fortified spread among moderately underweight 6-18-month-old rural Malawian children ." Maternal & Child Nutrition 5 , no. 2 (2009) : 159-70
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Pandya, V. P., Joshi, I. V., Sheth, A. M., Kadri, A. M.. "Studying the effectiveness of mixed models of community based and institutional based interventions for management of severe acute malnourished children ." International Journal of Research in Medical Sciences 3 , no. 7 (2015) : 1758-1764
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Other
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Leroy, J., Heckert, J., Ruel, M., Cunningham, K.. "Strengthening and evaluating the Preventing Malnutrition in Children under 2 Years of Age approach – Burundi Follow-up Report: Children 0–23 Months ." FANTA III (2014)
Study Interventions
  • Standard Fortified Food Blends
  • Behavior change communication (BCC)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Bourdier, F.. "Socio-anthropological investigation related to the acceptability of Plumpy'nut in Cambodia ." Paris: institut de Recherche pour le Développement (2009)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Adu-Afarwuah, S., Lartey, A., Okronipa, H., Ashorn, P., Peerson, J. M., Arimond, M., Ashorn, U., Zeilani, M., Vosti, S., Dewey, K. G.. "Small-quantity, lipid-based nutrient supplements provided to women during pregnancy and 6 mo postpartum and to their infants from 6 mo of age increase the mean attained length of 18-mo-old children in semi-urban Ghana: a randomized controlled trial ." The American Journal of Clinical Nutrition 104 , no. 3 (2016) : 797-808
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Hess, S. Y., Abbeddou, S., Jimenez, E. Y., Somé, J. W., Vosti, Stephen A, Ouédraogo, Z. P., Guissou, R. M., Ouédraogo, J., Brown, K. H.. "Small-quantity lipid-based nutrient supplements, regardless of their zinc content, increase growth and reduce the prevalence of stunting and wasting in young burkinabe children: a cluster-randomized trial ." PloS One 10 , no. 3 (2015) : e0122242
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Maust, A., Koroma, A. S., Abla, C., Molokwu, N., Ryan, K. N., Singh, L., Manary, M. J.. "Severe and moderate acute malnutrition can be successfully managed with an integrated protocol in Sierra Leone ." The Journal of Nutrition 145 , no. 11 (2015) : 2604-2609
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Toe, L. C., Bouckaert, K. P., De Beuf, K., Roberfroid, D., Meda, N., Thas, O., Van Camp, J,, Kolsteren, P. W., Huybregts, L. F.. "Seasonality modifies the effect of a lipid-based nutrient supplement for pregnant rural women on birth length ." The Journal of Nutrition 145 , no. 3 (2015) : 634-639
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Burza, S., Mahajan, R., Marino, E., Sunyoto, T., Shandilya, C., Tabrez, M., Kumar, K., Jha, A, Mathew, P., Salse, N., Casademont, C., Mishra, N. K.. "Seasonal effect and long-term nutritional status following exit from a Community-Based Management of Severe Acute Malnutrition program in Bihar, India ." European Journal of Clinical Nutrition 70 , no. 4 (2016) : 437-44
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Animal-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Isanaka, S., Langendorf, C., Berthé, F., Gnegne, S., Li, N., Ousmane, N., Harouna, S., Hassane, H., Schaefer, M., Adehossi, E., Grais, R. F.. "Routine amoxicillin for uncomplicated severe acute malnutrition in children ." The New England Journal of Medicine 374 (2016) : 444-453
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Other
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Flax, V. L., Mäkinen, S., Ashorn, U., Cheung, Y. B., Maleta, K., Ashorn, P., Bentley, M. E.. "Responsive feeding and child interest in food vary when rural Malawian children are fed lipid‐based nutrient supplements or local complementary food ." Maternal & Child Nutrition 9 , no. 3 (2013) : 369-380
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Medoua, G. N., Ntsama, P. M., Ndzana, A. C., Essa'a, V. J., Tsafack, J. J., Dimodi, H. T.. "Recovery rate of children with moderate acute malnutrition treated with ready-to-use supplementary food (RUSF) or improved corn–soya blend (CSB+): a randomized controlled trial ." Public Health Nutrition 19 , no. 2 (2016) : 363-370
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Shanka, N. A., Lemma, S., Abyu, D. M.. "Recovery rate and determinants in treatment of children with severe acute malnutrition using outpatient therapeutic feeding program in Kamba District, South West Ethiopia     ." Journal of Nutritional Disorders & Therapy 5 , no. 2 (2015)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Jones, K. D., Ali, R., Khasira, M. A., Odera, D., West, A. L., Koster, G., Akomo, P., Talbert, A. W., Goss, V. M., Ngari, M., Thitiri, J., Ndoro, S., Knight, M. A. G., Omollo, K., Ndungu, A., Mulongo, M. M., Bahwere, P., Fegan, G., Warner, J. O., Postle, A. D., Collins, S., Calder, P. C., Berkley, J. A.. "Ready-to-use therapeutic food with elevated n-3 polyunsaturated fatty acid content, with or without fish oil, to treat severe acute malnutrition: a randomized controlled trial     ." BMC Medicine 13 , no. 1 (2015) : 93
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Composition
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Delchevalerie, P., Herp, M. V.. "Ready-to-use supplementary food versus corn soya blend with oil premix to treat moderate acute child malnutrition: a community-based cluster randomized trial ." (2007)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Iannotti, L. L., Henretty, N. M., Delnatus, J. R., Previl, W., Stehl, T., Vorkoper, S., Bodden, J., Maust, A., Smidt, R., Nash, M. L., Tamimie, C. A., Owen, B. C., Wolff, P. B.. "Ready-to-use supplementary food increases fat mass and BMI in Haitian school-aged children ." The Journal of Nutrition 145 , no. 4 (2015) : 813-822
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Composition
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Bisimwa, G., Owino, V. O., Bahwere, P., Dramaix, M., Donnen, P., Dibari, F., Collins, S.. "Randomized controlled trial of the effectiveness of a soybean-maize-sorghum-based ready-to-use complementary food paste on infant growth in South Kivu, Democratic Republic of Congo ." American Journal of Clinical Nutrition 95 , no. 5 (2012) : 1157-1164
Study Interventions
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Lakkam, M., Wager, S., Wise, P. H., Wein, L. M.. "Quantifying and exploiting the age dependence in the effect of supplementary food for child undernutrition ." PloS One 9 , no. 6 (2014) : e99632
Study Interventions
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
Maleta, K. M., Phuka, J., Alho, L., Cheung, Y. B., Dewey,K. G., Ashorn, U., Phiri, N., Phiri, T. E., Vosti, S. A., Zeilani, M., Kumwenda, C., Bendabenda, J., Pulakka, A., Ashorn, P.. "Provision of 10–40 g/d lipid-based nutrient supplements from 6 to 18 months of age does not prevent linear growth faltering in Malawi   ." The Journal of Nutrition 145 , no. 8 (2015) : 1909-15
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight