Published Clinical Trials

This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 226 - 250 of 337 Results
Mangani, C., Cheung, Y. B., Maleta, K., Phuka, J., Thakwalakwa, C., Dewey, K., Manary, M., Puumalainen, T., Ashorn, P.. "Providing lipid-based nutrient supplements does not affect developmental milestones among Malawian children ." Acta Paediatrica 103 , no. 1 (2014) : e17-26
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Kerac, M., Bunn, J., Seal, A., Thindwa, M., Tomkins, A., Sadler, K., Bahwere, P., Collins, S.. "Probiotics and prebiotics for severe acute malnutrition (PRONUT study): a double-blind efficacy randomised controlled trial in Malawi ." The Lancet 374 , no. 9684 (2009) : 136-144
Study Interventions
  • Other
  • Animal-source protein
Research Gaps
  • Efficacy
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Sayyad-Neerkorn, J., Langendorf, C., Roederer, T., Doyon, S., Mamaty, A., Woi-Messe, L., Manzo, M. L., Harouna, S., de Pee, S., Grais, R. F.. "Preventive effects of long-term supplementation with 2 nutritious food supplements in young children in Niger     ." The Journal of Nutrition 145 , no. 11 (2015) : 2596-2603
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Kerac, M., Seal, A.. "Preventing acute malnutrition in young children: Improving the evidence for current and future practice ." PLoS Medicine 11 , no. 9 (2014) : e1001715
Study Interventions
  • Cash transfer
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Treatment of Severe Acute Malnutrition
Shamim, A. A., Hanif, Abu A. M., Merrill, R. D., Campbell, R. K., Kumkum, M. A., Shaikh, S., de Pee, S., Ahmed, T., Parveen, M., Mehra, S., Klemm, R. D. W., Labrique, A. B., West, K. P., Christian, P.. "Preferred delivery method and acceptability of Wheat-Soy Blend (WSB++) as a daily complementary food supplement in northwest Bangladesh     ." Ecology of Food and Nutrition 54 , no. 1 (2015) : 74-92
Study Interventions
  • Standard Fortified Food Blends
  • Animal-source protein
Research Gaps
  • Acceptability
  • Innovation
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Phuka, John C, Maleta, Kenneth, Thakwalakwa, Chrissie, Cheung, Yin Bun, Briend, André, Manary, Mark J, Ashorn, Per. "Postintervention growth of Malawian children who received 12-mo dietary complementation with a lipid-based nutrient supplement or maize-soy flour ." The American Journal of Clinical Nutrition 89 , no. 1 (2009)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Subramanian, S., Huq, S., Yatsunenko, T., Haque, R., Mahfuz, M., Alam, M. A., Benezra, A., DeStefano, J., Meier, M. F., Muegge, B. D., Barratt, M. J., VanArendonk, L. G., Zhang, Q., Province, M. A., Petri, W. A., Ahmed, T., Gordon, J. I.. "Persistent gut microbiota immaturity in malnourished Bangladeshi children ." Nature 510 , no. 7505 (2014) : 417-21
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Environmental enteric dysfunction (EED)
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Ali, E., Zachariah, R., Shams, Z., Manzi, M., Akter, T., Alders, P., Allaouna, M., Delchevalerie, P., Harries, A. D.. "Peanut-based ready-to-use therapeutic food: How acceptable and tolerated is it among malnourished pregnant and lactating women in Bangladesh? ." Maternal & Child Nutrition 11 , no. 4 (2015) : 1028-1035
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Ali, E., Zachariah, R., Dahmane, A., Van den Boogaard, W., Shams, Z., Akter, T., Alders, P., Manzi, M., Allaouna, M., Draguez, B., Delchevalerie, P., Harries, A. D.. "Peanut-based ready-to-use therapeutic food: acceptability among malnourished children and community workers in Bangladesh ." Public Health Action 3 , no. 2 (2013) : 128-135
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Caparros Megido, R., Alabi, T., Nieus, C., Blecker, C., Danthine, ., Bogaert, J., Haubruge, E., Francis, F.. "Optimisation of a cheap and residential small‐scale production of edible crickets with local by‐products as an alternative protein‐rich human food source in Ratanakiri Province, Cambodia ." Journal of the Science of Food and Agriculture 96 , no. 2 (2015) : 627-632
Study Interventions
  • Locally produced
  • Animal-source protein
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Simpore, J., Kabore, F., Zongo, F., Dansou, D., Bere, A., Pignatelli, S., Biondi, D. M., Ruberto, G., Musumeci, S.. "Nutrition rehabilitation of undernourished children utilizing Spiruline and Misola ." Nutrition Journal 5 , no. 3 (2006)
Study Interventions
  • Other
  • Locally produced
Research Gaps
  • Composition
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Perignon, M., Fiorentino, M., Kuong, K., Chamnan, C., Parker, M., Burja, K., Berger, J., Wieringa, F. T.. "Multi-micronutrient fortified rice improved vitamin A status of Cambodian school children ." European Journal of Nutrition & Food Safety 5 , no. 5 (2015) : 832-833
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Ray, S.. "Micronutrient supplementation, dietary intervention and resulting body weight gain of severe acute malnourished children–a pilot project study of OJUS Medical Institute ." Indian Journal of Community Health 26 , no. 6 (2014) : 160-165
Study Interventions
  • Micronutrient powders (MNP)
  • Locally produced
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Tang, M., Sheng, X. Y., Krebs, N. F., Hambidge, K. M.. "Meat as complementary food for older breastfed infants and toddlers: a randomized, controlled trial in rural China ." Food and Nutrition Bulletin 35 , no. 4 Suppl (2014) : S188-192
Study Interventions
  • Plant-source protein
  • Locally produced
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Sethuraman, K., Doledec, D., Begum, F., Manir, M. Z.. "Managing acute malnutrition: A review of the evidence and country experiences in South Asia and a recommended approach for Bangladesh ." FANTA Project (2014)
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Locally produced
  • Animal-source protein
Research Gaps
  • Effectiveness
  • Efficacy
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Ackatia-Armah, R. S., McDonald, C. M., Doumbia, S., Erhardt, J. G., Hamer, D. H., Brown, K. H.. "Malian children with moderate acute malnutrition who are treated with lipid-based dietary supplements have greater weight gains and recovery rates than those treated with locally produced cereal-legume products: a community-based, cluster-randomized trial ." American Journal of Clinical Nutrition 101 , no. 3 (2015) : 632-645
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Ashorn, U., Alho, L., Arimond, M., Dewey, K. G., Maleta, K., Phiri, N., Phuka, J., Vosti, S. A., Zeilani, M., Ashorn, P.. "Malawian mothers consider lipid-based nutrient supplements acceptable for children throughout a 1-year intervention, but deviation from user recommendations is common ." The Journal of Nutrition 145 , no. 7 (2015) : 1588-1595
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Flax, V. L., Thakwalakwa, C., Phuka, J., Ashorn, U., Cheung, Y. B., Maleta, K., Ashorn, P.. "Malawian mothers' attitudes towards the use of two supplementary foods for moderately malnourished children ." Appetite 53 , no. 2 (2009) : 195-202
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Standard Fortified Food Blends
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
James, P. T., Van den Briel, N., Rozet, A., Israël, A. D., Fenn, B., Navarro-Colorado, C.. "Low‐dose RUTF protocol and improved service delivery lead to good programme outcomes in the treatment of uncomplicated SAM: a programme report from Myanmar ." Maternal & Child Nutrition 11 , no. 4 (2015) : 859-869
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Severe Acute Malnutrition
Huynh, D. T., Estorninos, E., Capeding, R. Z., Oliver, J. S., Low, Y. L., Rosales, F. J.. "Longitudinal growth and health outcomes in nutritionally at-risk children who received long-term nutritional intervention ." Journal of Human Nutrition and Dietetics 28 , no. 6 (2015) : 623-35
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Scherbaum, V., Purwestri, R. C., Stuetz, W., Inayati, D. A., Suryantan, J., Bloem, M. A., Biesalski, H. K.. "Locally produced cereal/nut/legume-based biscuits versus peanut/milk-based spread for treatment of moderately to mildly wasted children in daily programmes on Nias Island, Indonesia: an issue of acceptance and compliance? ." Asia Pacific Journal of Clinical Nutrition 24 , no. 1 (2015) : 152
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Other
  • Behavior change communication (BCC)
  • Animal-source protein
Research Gaps
  • Acceptability
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Singh, A. S., Kang, G., Ramachandran, A., Sarkar, R., Peter, P., Bose, A.. "Locally made ready to use therapeutic food for treatment of malnutrition a randomized controlled trial ." Indian Pediatrics 47 , no. 8 (2010)
Study Interventions
  • Standard Fortified Food Blends
  • Locally produced
  • Animal-source protein
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
Dewey, K. G., Arimond, M.. "Lipid-based nutrient supplements: how can they combat child malnutrition? ." PLoS Medicine 9 , no. 9 (2012) : e1001314
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Plant-source protein
  • Animal-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Treatment of Moderate Acute Malnutrition
  • Prevention of Stunting, Wasting, and Underweight
  • Treatment of Severe Acute Malnutrition
Hemsworth, J., Kumwenda, C., Arimond, M., Maleta, K., Phuka, J., Rehman, A. M., Vosti, S. A., Ashorn, U., Filteau, S., Dewey, K. G., Ashorn, P., Ferguson, E. L.. "Lipid-based nutrient supplements increase energy and macronutrient intakes from complementary food among Malawian infants ." The Journal of Nutrition 146 , no. 2 (2016) : 326-34
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight
Mridha, M. K., Matias, S. L., Chaparro, C. M., Paul, R. R., Hussain, S., Vosti, S. A., Harding, K. L., Cummins, J. R., Day, L. T., Saha, S. L., Peerson, J. M., Dewey, K. G.. "Lipid-based nutrient supplements for pregnant women reduce newborn stunting in a cluster-randomized controlled effectiveness trial in Bangladesh ." The American of Clinical Nutrition 103 , no. 1 (2016) : 236-49
Study Interventions
  • Standard Lipid-Based Nutrient Supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Prevention of Stunting, Wasting, and Underweight