Published Studies

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This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 17 of 17 Results
Adu-Afarwuah, S., Lartey, A., Zeilani, M., Dewey, K. G.. "Acceptability of lipid-based nutrient supplements (LNS) among Ghanaian infants and pregnant or lactating women ." Maternal & Child Nutrition 7 , no. 4 (2011) : 344-56
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women
Prado, E. L., Adu-Afarwuah, S., Lartey, A., Ocansey, M., Ashorn, P., Vosti, S. A., Dewey, K. G.. "Effects of pre- and post-natal lipid-based nutrient supplements on infant development in a randomized trial in Ghana ." Early Human Development 99 (2016) : 43-51
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women
Adu-Afarwuah, S., Lartey, A., Okronipa, H., Peerson, J., Ashorn, P., Dewey, K.. "Effects of small-quantity lipid-based nutrient supplement on hemoglobin and iron status of pregnant Ghanaian women ." The FASEB Journal 29 , no. 1_Supplement (2015) : 39.5-
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Pregnant & Lactating Women
Adu-Afarwuah, S., Lartey, A., Okronipa, H., Ashorn, P., Zeilani, M., Peerson, J. M., Arimond, M., Vosti, S., Dewey, K. G.. "Lipid-based nutrient supplement increases the birth size of infants of primiparous women in Ghana ." The American Journal of Clinical Nutrition 101 , no. 4 (2015) : 835-46
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women
Adu-Afarwuah, S., Lartey, A., Okronipa, H., Ashorn, P., Peerson, J. M., Arimond, M., Ashorn, U., Zeilani, M., Vosti, S., Dewey, K. G.. "Small-quantity, lipid-based nutrient supplements provided to women during pregnancy and 6 mo postpartum and to their infants from 6 mo of age increase the mean attained length of 18-mo-old children in semi-urban Ghana: a randomized controlled trial ." The American Journal of Clinical Nutrition 104 , no. 3 (2016) : 797-808
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • GAM
Abizari, A., Moretti, D., Zimmermann, M. B., Armar-Klemesu, M., Brouwer, I. D.. "Whole cowpea meal fortified with NaFeEDTA reduces iron deficiency among Ghanaian school children in a malaria endemic area ." The Journal of Nutrition 142 , no. 10 (2012) : 1836-1842
Study Interventions
  • Fortified blended foods (FBF)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
Nutritional Problems being Studied
  • Stunted
Arimond, M., Zeilani, M., Jungjohann, S., Brown, K. H., Ashorn, P., Allen, L. H., Dewey, K. G.. "Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS) Project ." Maternal & Child Nutrition 11 , no. S4 (2015) : 31-61
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Stunted
Klevor, M. K., Adu-Afarwuah, S., Ashorn, P., Arimond, M., Dewey, K. G., Lartey, A., Maleta, K., Phiri, N., Pyykko, J., Zeilani, M., Ashorn, U.. "A mixed method study exploring adherence to and acceptability of small quantity lipid-based nutrient supplements (SQ-LNS) among pregnant and lactating women in Ghana and Malawi ." BMC Pregnancy and Childbirth 16 , no. 1 (2016) : 253
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women
Oaks, B. M., Young, R. R., Adu-Afarwuah, S., Ashorn, U., Jackson, K. H., Lartey, A., Maleta, K., Okronipa, H., Sadalaki, J., Baldiviez, L. M., Shahab-Ferdows, S., Ashorn, P., Dewey, K. G.. "Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials ." Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) 117 (2017) : 28-35
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Nutritional Problems being Studied
  • Stunted
Weber, J. M., Ryan, K. N., Tandon, R., Mathur, M., Girma, T., Steiner-Asiedu, M., Saalia, F., Zaidi, S., Soofi, S., Okos, M., Vosti, S. A.. "Acceptability of locally produced ready-to-use therapeutic foods in Ethiopia, Ghana, Pakistan and India ." Maternal & Child Nutrition 13 , no. 2 (2017) : e12250
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
Research Gaps
  • Acceptability
  • Cost
  • Innovation
Nutritional Problems being Studied
  • MAM
Adu-Afarwuah, S., Lartey, A., Okronipa, H., Ashorn, P., Zeilani, M., Oaks, B. M., Baldiviez, L. M., Vosti, S., Dewey, K. G.. "Impact of small-quantity lipid-based nutrient supplement on hemoglobin, iron status and biomarkers of inflammation in pregnant Ghanaian women ." Maternal & Child Nutrition 12 , no. 2 (2017)
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Pregnant & Lactating Women
Akparibo, R., Harris, J., Blank, L., Campbell, M. J., Holdsworth, M.. "Severe acute malnutrition in children aged under 5 years can be successfully managed in a non-emergency routine community healthcare setting in Ghana ." Maternal & Child Nutrition 13 , no. 4 (2017)
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • SAM
Kohlmann K, Callaghan-Gillespie M, Gauglitz JM, Steiner-Asiedu M, Saalia K, Edwards C, Manary MJ.. "BACKGROUND: Only 20% of children with severe acute malnutrition (SAM) have access to ready-to-use therapeutic food (RUTF), and RUTF cost limits its accessibility. METHODS: This randomized, double-blind controlled study involved a clinical equivalence trial comparing the effectiveness of an alternative RUTF with standard RUTF in the home-based treatment of uncomplicated SAM and moderate malnutrition in Ghanaian children aged 6 to 59 months. The primary outcome was recovery, equivalence was defined as being within 5 percentage points of the control group, and an intention-to-treat analysis was used. Alternative RUTF was composed of whey protein, soybeans, peanuts, sorghum, milk, sugar, and vegetable oil. Standard RUTF included peanuts, milk, sugar, and vegetable oil. The cost of alternative RUTF ingredients was 14% less than standard RUTF. Untargeted metabolomics was used to characterize the bioactive metabolites in the RUTFs. RESULTS: Of the 1,270 children treated for SAM or moderate malnutrition, 554 of 628 (88%) receiving alternative RUTF recovered (95% confidence interval [CI]=85% to 90%) and 516 of 642 (80%) receiving standard RUTF recovered (95% CI=77% to 83%). The difference in recovery was 7.7% (95% CI=3.7% to 11.7%). Among the 401 children with SAM, the recovery rate was 130 of 199 (65%) with alternative RUTF and 156 of 202 (77%) with standard RUTF (P=.01). The default rate in SAM was 60 of 199 (30%) for alternative RUTF and 41 of 202 (20%) for standard RUTF (P=.04). Children enrolled with SAM who received alternative RUTF had less daily weight gain than those fed standard RUTF (2.4 ± 2.4 g/kg vs. 2.9 ± 2.6 g/kg, respectively; P<.05). Among children with moderate wasting, recovery rates were lower for alternative RUTF, 386 of 443 (87%), than standard RUTF, 397 of 426 (93%) (P=.003). More isoflavone metabolites were found in alternative RUTF than in the standard. CONCLUSION: The lower-cost alternative RUTF was less effective than standard RUTF in the treatment of severe and moderate malnutrition in Ghana. ." Global Health: Science and Practice 7 , no. 2 (2019) : 203-214
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Kwaku Tano-Debrah, PhD, Firibu Kwesi Saalia, PhD, Shibani Ghosh, PhD, Masashi Hara, PhD. "." Food And Nutrition Bulletin (2019)
Study Interventions
  • Fortified blended foods (FBF)
  • Locally produced
Research Gaps
  • Acceptability
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • MAM
Maku E Ocansey, Seth Adu-Afarwuah, Sika M Kumordzie, Harriet Okronipa, Rebecca R Young, Solace M Tamakloe, Brietta M Oaks, Kathryn G Dewey, and Elizabeth L Prado. "." The American Journal of Clinical Nutrition 109 , no. 2 (2019) : 322–334
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • MAM
Sika M Kumordzie, Seth Adu-Afarwuah, Mary Arimond, Rebecca R Young, Theodosia Adom, Rose Boatin, Maku E Ocansey, Harriet Okronipa, Elizabeth L Prado, Brietta M Oaks, and Kathryn G Dewey.. "." The Journal of Nutrition 149 , no. 5 (2019) : 847–855
Study Interventions
  • Fortified blended foods (FBF)
  • Locally produced
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Harriet Okronipa, Mary Arimond, Charles D Arnold, Rebecca R Young, Seth Adu-Afarwuah, Solace M Tamakloe, Maku E Ocansey, Sika M Kumordzie, Brietta M Oaks, Julie A Mennella, and Kathryn G Dewey.. "." American Journal of Clinical Nutrition 109 , no. 4 (2019) : 1224–1232
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • MAM