Published Studies

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This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 62 Results
Thakwalakwa, C., Ashorn, P., Phuka, J., Cheung, Y. B., Briend, A., Puumalainen, T., Maleta, K.. "A lipid-based nutrient supplement but not corn-soy blend modestly increases weight gain among 6-to 18-month-old moderately underweight children in rural Malawi ." The Journal of Nutrition 140 , no. 11 (2010) : 2008-2013
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
LaGrone, L. N., Trehan, I., Meuli, G. J., Wang, R. J., Thakwalakwa, C., Maleta, K., Manary, M. J.. "A novel fortified blended flour, corn-soy blend "plus-plus," is not inferior to lipid-based ready-to-use supplementary foods for the treatment of moderate acute malnutrition in Malawian children ." The American Journal of Clinical Nutrition 95 , no. 1 (2012) : 212-9
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Oakley, E., Reinking, J., Sandige, H., Trehan, I., Kennedy, G., Maleta, K., Manary, M.. "A ready-to-use therapeutic food containing 10% milk is less effective than one with 25% milk in the treatment of severely malnourished children ." The Journal of Nutrition 140 , no. 12 (2010) : 2248-2252
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Efficacy
Nutritional Problems being Studied
  • SAM
Mangani, C., Manary, M., Alho, L., Ashorn, P.. "A single-centre, randomized, single-blind, parallel group clinical trial in rural Malawi, testing the growth promoting effect of long-term complementary feeding of infants with a high-energy, micronutrient fortified spread ." FANTA Project (2012)
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • MAM
Langlois, B., Rogers, B.. "A tale of two measures: Self-report and lab-assessed values in amount of oil Added to CSB porridge prepared by caregivers of children with moderate acute malnutrition in Southern Malawi ." The FASEB Journal 30 , no. 1 (2016)
Study Interventions
  • Behavior change communication (BCC)
  • Fortified blended foods (FBF)
Research Gaps
  • Use
Nutritional Problems being Studied
  • MAM
Phuka, J., Ashorn, U., Ashorn, P., Zeilani, M., Cheung, Y. B., Dewey, K. G., Manary, M., Maleta, K.. "Acceptability of three novel lipid-based nutrient supplements among Malawian infants and their caregivers ." Maternal & Child Nutrition 7 , no. 4 (2011) : 368-377
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
  • Composition
  • Innovation
Nutritional Problems being Studied
  • MAM
Thakwalakwa, C. M., Ashorn, P., Jawati, M., Phuka, J. C., Cheung, Y. B., Maleta, K. M.. "An effectiveness trial showed lipid-based nutrient supplementation but not corn-soya blend offered a modest benefit in weight gain among 6- to 18-month-old underweight children in rural Malawi ." Public Health Nutrition 15 , no. 9 (2012) : 1755-62
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Trehan, I., Goldbach, H. S., LaGrone, L. N., Meuli, G. J., Wang, R. J., Maleta, K. M., Manary, M. J.. "Antibiotics as part of the management of severe acute malnutrition ." New England Journal of Medicine 368 , no. 5 (2013) : 425-435
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • SAM
Chang, C. Y., Trehan, I., Wang, R. J., Thakwalakwa, C., Maleta, K., Deitchler, M., Manary, M. J.. "Children successfully treated for moderate acute malnutrition remain at risk for malnutrition and death in the subsequent year after recovery ." The Journal of Nutrition 143 , no. 2 (2013) : 215-220
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Manary, M., Chang, C.. "Comparing milk-fortified corn-soy blend (CSB++), soy ready-to-use supplementary food (RUSF), and soy/whey RUSF (Supplementary Plumpy®) in the treatment of moderate acute malnutrition ." FANTA Project (2012)
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Composition
Nutritional Problems being Studied
  • MAM
Phuka, J. C., Gladstone, M., Maleta, K., Thakwalakwa, C., Cheung, Y. B., Briend, A., Manary, M. J., Ashorn, P.. "Developmental outcomes among 18‐month‐old Malawians after a year of complementary feeding with lipid‐based nutrient supplements or corn‐soy flour ." Maternal & Child Nutrition 8 , no. 2 (2012) : 239-248
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Bahwere, P., Banda, T., Sadler, K., Nyirenda, G., Owino, V., Shaba, B., Dibari, F., Collins, S.. "Effectiveness of milk whey protein-based ready-to-use therapeutic food in treatment of severe acute malnutrition in Malawian under-5 children: a randomised, double-blind, controlled non-inferiority clinical trial ." Maternal & Child Nutrition 10 , no. 3 (2014) : 436-451
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • SAM
Prado, E. L., Maleta, K., Ashorn, P., Ashorn, U., Vosti, S. A., Sadalaki, J., Dewey, K. G.. "Effects of maternal and child lipid-based nutrient supplements on infant development: a randomized trial in Malawi ." American Journal of Clinical Nutrition 103 , no. 3 (2016) : 784-793
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
Trehan, I., Banerjee, S., Murray, E.. "Extending supplementary feeding for children younger than 5 years with moderate acute malnutrition leads to lower relapse rates ." Journal of Pediatric Gastroenterology & Nutrition 60 , no. 4 (2015) : 544-549
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Flax, V. L., Phuka, J., Cheung, Y. B., Ashorn, U., Maleta, K., Ashorn, P.. "Feeding patterns and behaviors during home supplementation of underweight Malawian children with lipid-based nutrient supplements or corn-soy blend ." Appetite 54 , no. 3 (2010) : 504-11
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Use
Nutritional Problems being Studied
  • MAM
Kerac, M., Bunn, J., Chagaluka, G., Bahwere, P., Tomkins, A., Collins, S., Seal, A.. "Follow-up of post-discharge growth and mortality after treatment for severe acute malnutrition (FuSAM study): a prospective cohort study ." PloS One 9 , no. 6 (2014) : e96030
Study Interventions
  • Other
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • SAM
Reyes, A., Blanton, L. V., Cao, S., Zhao, G., Manary, M., Trehan, I., Smith, M. I., Wang, D., Virgin, H. W., Rohwer, F., Gordon, J. I.. "Gut DNA viromes of Malawian twins discordant for severe acute malnutrition ." Proceedings of the National Academy of Sciences 112 , no. 38 (2015) : 11941-11946
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Nutritional Problems being Studied
  • SAM
Smith, M. I., Yatsunenko, T., Manary, M. J., Trehan, I., Mkakosya, R., Cheng, J., Kau, A. L., Rich, S. S., Concannon, P., Mychaleckyj, J. C., Liu, J., Houpt, E., Li, J. V., Holmes, E., Nicholson, J., Knights, D., Ursell, L. K., Knight, R., Gordon, J. I.. "Gut microbiomes of Malawian twin pairs discordant for kwashiorkor ." Science 339 , no. 6119 (2013) : 548-554
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • SAM
Cheung, Y. B., Xu, Y., Mangani, C., Fan, Y. M., Dewey, K. G., Salminen, S. J., Maleta, K., Ashorn, P.. "Gut microbiota in Malawian infants in a nutritional supplementation trial ." Tropical Medicine & International Health 21 , no. 2 (2015) : 283-90
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
  • Plant-source protein
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • MAM
Hsieh, J. C., Liu, L., Zeilani, M., Ickes, S., Trehan, I., Maleta, K., Craig, C., Thakwalakwa, C., Singh, L., Brenna, J. T., Manary, M. J.. "High oleic ready-to-use therapeutic food maintains docosahexaenoic acid status in severe malnutrition: A randomized, blinded trial ." Journal of Pediatric Gastroenterology and Nutrition 61 , no. 1 (2015) : 138-143
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • SAM
Kodish, S., Aburto, N., Hambayi, M. N., Kennedy, C., Gittelsohn, J.. "Identifying the sociocultural barriers and facilitating factors to nutrition-related behavior change formative research for a stunting prevention program in Ntchisi, Malawi ." Food and Nutrition Bulletin 36 , no. 2 (2015) : 138-153
Study Interventions
  • Behavior change communication (BCC)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Stunted
Zhang, L., Voskuijl, W., Mouzaki, M., Groen, A. K., Alexander, J., Bourdon, C., Wang, A., Versloot, C. J., Di Giovanni, V., Wanders, R. J. A., Bandsma, R. H.. "Impaired bile acid homeostasis in children with severe acute malnutrition ." PLoS ONE 11 , no. 5 (2016) : e0155143
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • SAM
Stobaugh, H. C., Ryan, K. N., Kennedy, J. A., Grise, J. B., Crocker, A. H., Thakwalakwa, C., Litkowski, P. E., Maleta, K. M., Manary, M. J., Trehan, I.. "Including whey protein and whey permeate in ready-to-use supplementary food improves recovery rates in children with moderate acute malnutrition: a randomized, double-blind clinical trial ." American Journal of Clinical Nutrition 103 , no. 3 (2016) : 926-933
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
Nutritional Problems being Studied
  • MAM
Wang, R. J., Trehan, I., LaGrone, L. N., Weisz, A. J., Thakwalakwa, C. M., Maleta, K. M., Manary, M. J.. "Investigation of food acceptability and feeding practices for lipid nutrient supplements and blended flours used to treat moderate malnutrition ." Journal of Nutrition Education and Behavior 45 , no. 3 (2013) : 258-263
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • MAM
Flax, V. L., Bentley, M. E., Chasela, C. S., Kayira, D., Hudgens, M. G., Kacheche, K. Z., Chavula, C., Kourtis, A. P., Jamieson, D. J., van der Horst, C. M.. "Lipid-based nutrient supplements are feasible as a breastmilk replacement for HIV-exposed infants from 24 to 48 weeks of age ." The Journal of Nutrition 143 , no. 5 (2013) : 701-707
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women