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This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 141 Results
Thakwalakwa, C., Ashorn, P., Phuka, J., Cheung, Y. B., Briend, A., Puumalainen, T., Maleta, K.. "A lipid-based nutrient supplement but not corn-soy blend modestly increases weight gain among 6-to 18-month-old moderately underweight children in rural Malawi ." The Journal of Nutrition 140 , no. 11 (2010) : 2008-2013
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
LaGrone, L. N., Trehan, I., Meuli, G. J., Wang, R. J., Thakwalakwa, C., Maleta, K., Manary, M. J.. "A novel fortified blended flour, corn-soy blend "plus-plus," is not inferior to lipid-based ready-to-use supplementary foods for the treatment of moderate acute malnutrition in Malawian children ." The American Journal of Clinical Nutrition 95 , no. 1 (2012) : 212-9
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Oakley, E., Reinking, J., Sandige, H., Trehan, I., Kennedy, G., Maleta, K., Manary, M.. "A ready-to-use therapeutic food containing 10% milk is less effective than one with 25% milk in the treatment of severely malnourished children ." The Journal of Nutrition 140 , no. 12 (2010) : 2248-2252
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Efficacy
Nutritional Problems being Studied
  • SAM
Langlois, B., Rogers, B.. "A tale of two measures: Self-report and lab-assessed values in amount of oil Added to CSB porridge prepared by caregivers of children with moderate acute malnutrition in Southern Malawi ." The FASEB Journal 30 , no. 1 (2016)
Study Interventions
  • Behavior change communication (BCC)
  • Fortified blended foods (FBF)
Research Gaps
  • Use
Nutritional Problems being Studied
  • MAM
Iuel-Brockdorf, A., Dræbelc, T. A., Fabiansenb, C., Cichon, B., Brix Christensen, V., Yameogob, C., Ritz, C., Frahm Olsen, M., Friis, H.. "Acceptability of new formulations of corn-soy blends and lipid-based nutrient supplements in Province du Passoré, Burkina Faso ." Appetite (2015)
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • MAM
Phuka, J., Ashorn, U., Ashorn, P., Zeilani, M., Cheung, Y. B., Dewey, K. G., Manary, M., Maleta, K.. "Acceptability of three novel lipid-based nutrient supplements among Malawian infants and their caregivers ." Maternal & Child Nutrition 7 , no. 4 (2011) : 368-377
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
  • Composition
  • Innovation
Nutritional Problems being Studied
  • MAM
Hess, S. Y., Bado, L., Aaron, G. J., Ouédraogo, J. B., Zeilani, M., Brown, K. H.. "Acceptability of zinc-fortified, lipid-based nutrient supplements (LNS) prepared for young children in Burkina Faso ." Maternal & Child Nutrition 7 , no. 4 (2011) : 357-367
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • MAM
Ruel, M. T., Menon, P., Habicht, J., Loechl, C., Bergeron, G., Pelto, G., Arimond, M., Maluccio, J., Michaud, L., Hankebo, B.. "Age-based preventive targeting of food assistance and behaviour change and communication for reduction of childhood undernutrition in Haiti: a cluster randomised trial ." The Lancet 371 , no. 9612 (2008) : 588-595
Study Interventions
  • Behavior change communication (BCC)
  • Fortified blended foods (FBF)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • MAM
Thakwalakwa, C. M., Ashorn, P., Jawati, M., Phuka, J. C., Cheung, Y. B., Maleta, K. M.. "An effectiveness trial showed lipid-based nutrient supplementation but not corn-soya blend offered a modest benefit in weight gain among 6- to 18-month-old underweight children in rural Malawi ." Public Health Nutrition 15 , no. 9 (2012) : 1755-62
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Trehan, I., Goldbach, H. S., LaGrone, L. N., Meuli, G. J., Wang, R. J., Maleta, K. M., Manary, M. J.. "Antibiotics as part of the management of severe acute malnutrition ." New England Journal of Medicine 368 , no. 5 (2013) : 425-435
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • SAM
Belachew, T., Nekatibeb, H.. "Assessment of outpatient therapeutic programme for severe acute malnutrition in three regions of Ethiopia ." East African Medical Journal 84 , no. 12 (2007) : 577-588
Study Interventions
  • Behavior change communication (BCC)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • SAM
Steenkamp, L., Nomvete, A., Venter, D.. "Catch-up growth in children with severe acute malnutrition: comparison of two therapeutic feeding approaches at a district hospital, South Africa ." Africa Journal of Nursing and Midwifery 17 , no. 2 (2016)
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • SAM
Bahwere, P., Balaluka, B., Wells, J. C., Mbiribindi, C. N., Sadler, K., Akomo, P., Dramaix-Wilmet, M., Collins, S.. "Cereals and pulse-based ready-to-use therapeutic food as an alternative to the standard milk- and peanut paste-based formulation for treating severe acute malnutrition: a noninferiority, individually randomized controlled efficacy clinical trial ." The American Journal of Clinical Nutrition 103 , no. 4 (2016) : 1145-1161
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Composition
  • Efficacy
Nutritional Problems being Studied
  • SAM
Tadesse, E., Ekström, E., Berhane, Y.. "Challenges in implementing the integrated community-based outpatient therapeutic program for severely malnourished children in rural Southern Ethiopia ." Nutrients 8 , no. 5 (2016) : 251
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • SAM
Namusoke, H., Hother, A., Rytter, M. J., Kæstel, P., Babirekere-Iriso, E., Fabiansen, C., Girma, T., Ritz, C., Michaelsen, K., Briend, A., Friis, H.. "Changes in plasma phosphate during in-patient treatment of children with severe acute malnutrition: an observational study in Uganda ." The American Journal of Clinical Nutrition (2016)
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • SAM
Babirekere-Iriso, E., Mortensen, C. G., Mupere, E., Rytter, M. J., Namusoke, H., Michaelsen, K. F., Briend, A., Stark, K. D., Friis, H., Lauritzen, L.. "Changes in whole-blood PUFA and their predictors during recovery from severe acute malnutrition ." The British Journal of Nutrition 115 , no. 10 (2016) : 1730-9
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • SAM
Chang, C. Y., Trehan, I., Wang, R. J., Thakwalakwa, C., Maleta, K., Deitchler, M., Manary, M. J.. "Children successfully treated for moderate acute malnutrition remain at risk for malnutrition and death in the subsequent year after recovery ." The Journal of Nutrition 143 , no. 2 (2013) : 215-220
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Mehta, B., Imran, A.. "Clinical and anthropometric profile of severe acute malnourished children on therapeutic intervention with WHO/UNICEF recommended therapeutic food ." International Journal of Science and Research 4 , no. 4 (2014) : 268-273
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • SAM
Portillo-Reyes, V., Pérez-García, M., Loya-Méndez, Y., Puente, A. E.. "Clinical significance of neuropsychological improvement after supplementation with omega-3 in 8–12 years old malnourished Mexican children: A randomized, double-blind, placebo and treatment clinical trial ." Research in Developmental Disabilities 35 , no. 4 (2014) : 861-870
Study Interventions
  • Other
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Burza, S., Mahajan, R., Marino, E., Sunyoto, T., Shandilya, C., Tabrez, M., Kumari, K., Mathew, P., Jha, A., Salse, N., Mishra, K. N., Marino, E.101. "Community-based management of severe acute malnutrition in India: new evidence from Bihar ." The American Journal of Clinical Nutrition 101 , no. 4 (2015) : 847-859
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • SAM
Ige, O. K., Oladokun, R. E., Kikelomo, O.. "Comparative weight gain with ready-to-use therapeutic food in stunted HIV-infected and-uninfected children in a Nigerian Hospital ." South African Journal of Child Health 8 , no. 3 (2014) : 104-107
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • SAM
Manary, M., Chang, C.. "Comparing milk-fortified corn-soy blend (CSB++), soy ready-to-use supplementary food (RUSF), and soy/whey RUSF (Supplementary Plumpy®) in the treatment of moderate acute malnutrition ." FANTA Project (2012)
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Composition
Nutritional Problems being Studied
  • MAM
Marron, B., Green, J., Jayson, L., Suri, D., Marcus, S., Boiteau, J., Manary, M., Webb, P., Rogers, B.. "Comparison of four different supplementary foods in the treatment of moderate acute malnutrition (MAM) in children under five in Sierra Leone ." The FASEB Journal 29 , no. 1 (2015)
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Diop, E. H. I., Dossou, N. I., Ndour, M. M., Briend, A., Wade, S.. "Comparison of the efficacy of a solid ready-to-use food and a liquid, milk-based diet for the rehabilitation of severely malnourished children: A randomized trial ." American Journal of Clinical Nutrition 78 , no. 2 (2003) : 302-307
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
  • Other
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • SAM
Puett, C., Sadler, K., Alderman, H., Coates, J., Fiedler, J. L., Myatt, M.. "Cost-effectiveness of the community-based management of severe acute malnutrition by community health workers in southern Bangladesh ." Health Policy and Planning 28 , no. 4 (2013) : 386-399
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Cost
Nutritional Problems being Studied
  • SAM