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This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 4 of 4 Results
Batra, P., Schlossman, N., Balan, I., Pruzensky, W., Balan, A., Brown, C., Gamache, M. G., Schleicher, M. M., Braima de Sa, A., Saltzman, E., Wood, L., Roberts, S. B.. "A randomized controlled trial offering higher- compared with lower-dairy second meals daily in preschools in Guinea-Bissau demonstrates an attendance-dependent increase in weight gain for both meal types and an increase in mid-upper arm circumference ." The Journal of Nutrition 146 , no. 1 (2015) : 124-132
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Stunted
  • MAM
Schlossman, N., Brown, C., Batra, P., Braima de Sa, A., Balan, I., Balan, A., Gamache, M. G., Wood, L., Pruzensky, W., Saltzman, E., Roberts, S. B., Bale, C.. "A randomized controlled trial of two ready-to-use supplementary foods demonstrates benefit of the higher dairy supplement for reduced wasting in mothers, and differential impact in infants and children associated with maternal supplement response ." Food and Nutrition Bulletin 38 , no. 3 (2017) : 275-290
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Pregnant & Lactating Women
  • GAM
Susan B. Roberts, Maria Angela Franceschini, Amy Krauss, Pei-Yi Lin, Augusto Braima de Sa, Raimundo Co ́, SalimaTaylor, Carrie Brown, Oliver Chen, Elizabeth J. Johnson, William Pruzensky, Nina Schlossman, Carlito Bale ́, Kuan-Cheng (Tony) Wu, Katherine Hagan, Edward Saltzman, Paul Muentener. "." Current Developments in Nutrition 1 , no. 11 (2017)
Study Interventions
  • Fortified blended foods (FBF)
  • Locally produced
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Taylor S, Silver R, Franceschini M, Muentener P, de Sa AB, Co R, Sonco A, Balé C, Saltzman E, Roberts S.. "  OBJECTIVES: Undernutrition is prevalent among young children worldwide and is associated with impaired cognition and reduced educational attainment. We conducted a randomized controlled trial to test the effect of a novel supplementary food (regenerative nutrition for enhanced wellness-cognition; RENEW-C) compared to traditional feeding practices on cognitive function, cerebral blood flow and oxygen metabolism in rural Guinea-Bissau. METHODS: Children aged 15 months to 7 years (n = 1059) were randomized to receive isocaloric quantities of RENEW-C (a highly-fortified cocoa-based bar), a USAID fortified blended food (FBF) or a Control food (rice cooked with oil, replicating a traditional breakfast). The primary outcome was executive function. Secondary outcomes included a cerebral blood flow index (CBFi) and cerebral metabolic rate of oxygen (CMRO2) measured by Frequency-Domain Near-Infrared Spectroscopy and Diffusion Correlation Spectroscopy (FDNIRS-DCS, MetaOx, ISS Inc.). Six-month changes for RENEW-C and FBF versus Controls were assessed by multivariable linear mixed models adjusted for age, sex, baseline measurement, and study cohort. RESULTS: Improvements in executive function (0.38; 95% CI: 0.10, 0.71; P = 0.02) were observed for RENEW-C compared to Controls in the predefined study focus (children < 4 years consuming >75% their supplement). There was no significant effect of RENEW-C in children ≥ 4 years. No benefit of the FBF was observed in either age group. In addition, changes in CBFi and CMRO2 in RENEW-C children were greater than in Controls in both ventrolateral prefrontal cortical regions (P = 0.03 and P = 0.04 for left and right, respectively) and greater than FBF in the left ventrolateral (P = 0.05) and left dorsolateral (P = 0.03) prefrontal cortices. CONCLUSIONS: Compared with traditional feeding practices, the RENEW-C supplement consumption was correlated with a marked improvement in executive function among children < 4 years and large increases in vascular perfusion and oxygen metabolism in a region where undernutrition is prevalent. These results indicate that new approaches to formulating supplementary foods for children at risk of undernutrition can potentially yield substantial improvements in brain health and cognition. ." Current Developments in Nutrition 3 , no. Supp 1 (2019)
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • MAM