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This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 28 Results
LaGrone, L. N., Trehan, I., Meuli, G. J., Wang, R. J., Thakwalakwa, C., Maleta, K., Manary, M. J.. "A novel fortified blended flour, corn-soy blend "plus-plus," is not inferior to lipid-based ready-to-use supplementary foods for the treatment of moderate acute malnutrition in Malawian children ." The American Journal of Clinical Nutrition 95 , no. 1 (2012) : 212-9
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Mangani, C., Manary, M., Alho, L., Ashorn, P.. "A single-centre, randomized, single-blind, parallel group clinical trial in rural Malawi, testing the growth promoting effect of long-term complementary feeding of infants with a high-energy, micronutrient fortified spread ." FANTA Project (2012)
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • MAM
Iuel-Brockdorf, A., Dræbelc, T. A., Fabiansenb, C., Cichon, B., Brix Christensen, V., Yameogob, C., Ritz, C., Frahm Olsen, M., Friis, H.. "Acceptability of new formulations of corn-soy blends and lipid-based nutrient supplements in Province du Passoré, Burkina Faso ." Appetite (2015)
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • MAM
Bahwere, P., Balaluka, B., Wells, J. C., Mbiribindi, C. N., Sadler, K., Akomo, P., Dramaix-Wilmet, M., Collins, S.. "Cereals and pulse-based ready-to-use therapeutic food as an alternative to the standard milk- and peanut paste-based formulation for treating severe acute malnutrition: a noninferiority, individually randomized controlled efficacy clinical trial ." The American Journal of Clinical Nutrition 103 , no. 4 (2016) : 1145-1161
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Composition
  • Efficacy
Nutritional Problems being Studied
  • SAM
Chang, C. Y., Trehan, I., Wang, R. J., Thakwalakwa, C., Maleta, K., Deitchler, M., Manary, M. J.. "Children successfully treated for moderate acute malnutrition remain at risk for malnutrition and death in the subsequent year after recovery ." The Journal of Nutrition 143 , no. 2 (2013) : 215-220
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Manary, M., Chang, C.. "Comparing milk-fortified corn-soy blend (CSB++), soy ready-to-use supplementary food (RUSF), and soy/whey RUSF (Supplementary Plumpy®) in the treatment of moderate acute malnutrition ." FANTA Project (2012)
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Composition
Nutritional Problems being Studied
  • MAM
Marron, B., Green, J., Jayson, L., Suri, D., Marcus, S., Boiteau, J., Manary, M., Webb, P., Rogers, B.. "Comparison of four different supplementary foods in the treatment of moderate acute malnutrition (MAM) in children under five in Sierra Leone ." The FASEB Journal 29 , no. 1 (2015)
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Langendorf, C., Roederer, T., de Pee, S., Brown, D., Doyon, S., Mamaty, A., Touré, L. W., Manzo, M. L., Grais, R. F.. "Preventing acute malnutrition among young children in crises: A prospective intervention study in Niger ." PLOS Medicine (2012)
Study Interventions
  • Animal-source protein
  • Cash transfer
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
  • Other
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • SAM
  • MAM
Phuka, J. C., Gladstone, M., Maleta, K., Thakwalakwa, C., Cheung, Y. B., Briend, A., Manary, M. J., Ashorn, P.. "Developmental outcomes among 18‐month‐old Malawians after a year of complementary feeding with lipid‐based nutrient supplements or corn‐soy flour ." Maternal & Child Nutrition 8 , no. 2 (2012) : 239-248
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Skau, J. K. H., Touch, B., Chhoun, C., Chea, M., Unni, U. S., Makurat, J., Filteau, S., Wieringa, F. T., Dijkhuizen, M. A., Ritz, C., Wells, J. C., Berger, J., Friis, H., Michaelsen, K. F., Roos, N.. "Effects of animal source food and micronutrient fortification in complementary food products on body composition, iron status, and linear growth: A randomized trial in Cambodia ." The American Journal of Clinical Nutrition 101 , no. 4 (2015) : 742-751
Study Interventions
  • Fortified blended foods (FBF)
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
Amegovu, Andrew Kiri, Ochola, Sophie, Ogwok, Patrick, Yiga, Peter, Musalima, Juliet, Juliana, Mandha. "Efficacy of sorghum peanut blend and corn soy blend plus in the treatment of moderate acute malnutrition in children aged 6–59 months in Karamoja, Uganda: a cluster randomized trial ." Nutrition & Dietary Supplements 6 (2014) : 75-84
Study Interventions
  • Fortified blended foods (FBF)
  • Locally produced
  • Plant-source protein
Research Gaps
  • Composition
  • Innovation
Nutritional Problems being Studied
  • MAM
Ackatia-Armah, R. S., McDonald, C. M., Doumbia, S., Erhardt, J. G., Hamer, D. H., Brown, K. H.. "Malian children with moderate acute malnutrition who are treated with lipid-based dietary supplements have greater weight gains and recovery rates than those treated with locally produced cereal-legume products: a community-based, cluster-randomized trial ." American Journal of Clinical Nutrition 101 , no. 3 (2015) : 632-645
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Mangani, C., Cheung, Y. B., Maleta, K., Phuka, J., Thakwalakwa, C., Dewey, K., Manary, M., Puumalainen, T., Ashorn, P.. "Providing lipid-based nutrient supplements does not affect developmental milestones among Malawian children ." Acta Paediatrica 103 , no. 1 (2014) : e17-26
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Matilsky, D. K., Maleta, K., Castleman, T., Manary, M. J.. "Supplementary feeding with fortified spreads results in higher recovery rates than with a corn/soy blend in moderately wasted children ." The Journal of Nutrition 139 , no. 4 (2009) : 773-778
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Abizari, A., Moretti, D., Zimmermann, M. B., Armar-Klemesu, M., Brouwer, I. D.. "Whole cowpea meal fortified with NaFeEDTA reduces iron deficiency among Ghanaian school children in a malaria endemic area ." The Journal of Nutrition 142 , no. 10 (2012) : 1836-1842
Study Interventions
  • Fortified blended foods (FBF)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
Nutritional Problems being Studied
  • Stunted
Delimont, N. M., Alavi, S., Lindshield, B.. "New formulations for fortified-blended foods: the MFFAPP Tanzania efficacy trial ." The FASEB Journal 31 , no. 1 (2017) : Supplement 786.15
Study Interventions
  • Fortified blended foods (FBF)
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
Kampstra, N. A., Van Hoan, N., Koenders, D. J. P. C., Schoop, R., Broersen, C. B., Mouquet-Rivier, C., Traore, T., Bruins, M. J., de Pee, S.. "Energy and nutrient intake increased by 47–67% when amylase was added to fortified blended foods—a study among 12- to 35-month-old Burkinabe children ." Maternal & Child Nutrition (2017)
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Stunted
  • GAM
Callaghan-Gillespie, M., Schaffner, A. A., Garcia, P., Fry, J., Eckert, R. , Malek, S., Trehan, I., Thakwalakwa, C., Maleta, K. M., Manary, M. J., Papathakis, P. C.. "Trial of ready-to-use supplemental food and corn-soy blend in pregnant Malawian women with moderate malnutrition: a randomized controlled clinical trial ." American Journal of Clinical Nutrition 106 , no. 4 (2017) : 1062-1069
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Pregnant & Lactating Women
  • MAM
Lin, C. A., Manary, M. J., Maleta, K., Briend, A., Ashorn, P.. "An energy-dense complementary food is associated with a modest increase in weight gain when compared with a fortified porridge in Malawian children aged 6–18 months ." Journal of Nutrition 138 (2008) : 593-598
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • GAM
Ackatia-Armah, R. S., McDonald, C., Doumbia, S., Brown, K. H.. "Effect of selected dietary regimens on recovery from moderate acute malnutrition in young Malian children ." The FASEB Journal 26 , no. 1 (2012)
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • MAM
Dube, B., Rongsen, T., Mazumder, S., Taneja, S., Rafiqui, F., Bhandari, N., Bhan, M. K.. "Comparison of ready-to-use therapeutic food with cereal legume-based Khichri among malnourished children ." Indian Pediatrics 46 (2009) : 383-388
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
Research Gaps
  • Acceptability
  • Composition
  • Innovation
Nutritional Problems being Studied
  • MAM
Christian Fabiansen, Kevin PQ Phelan, Bernardette Cichon, Christian Ritz, André Briend, Kim F Michaelsen, Henrik Friis, Susan Shepherd. "." American Journal of Clinical Nutrition 103 , no. 2 (2016) : 415-421
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Kevin B Stephenson, Sophia E Agapova, Oscar Divala, Yankho Kaimila, Kenneth M Maleta, Chrissie Thakwalakwa, M Isabel Ordiz, Indi Trehan, Mark J Manary. "." American Journal of Clinical Nutrition 106 , no. 6 (2017) : 1500-1507
Study Interventions
  • Environmental enteric dysfunction (EED)
  • Fortified blended foods (FBF)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Agapova, S. E., Stephenson, K. B., Divala, O., Kaimila, Y., Maleta K. M., Thakwalakwa, C. Ordiz, M. I., Trehan, I., Manary, M. J.. "BACKGROUND: Chronic malnutrition, as manifested by linear growth faltering, is pervasive among rural African children. Improvements in complementary feeding may decrease the burden of environmental enteric dysfunction (EED) and thus improve growth in children during the critical first 1000 d of development. OBJECTIVE: We tested the hypothesis that systematically including common bean or cowpea into complementary feeding would reduce EED and growth faltering among children in rural Malawi. METHODS: This was a double-blind clinical trial in which children 12-23 mo of age were randomly assigned to receive complementary feeding with 1 of 3 foods: roasted cowpea or common bean flour, or an isoenergetic amount of corn-soy blend as a control food for 48 wk. Children aged 12-23 mo received 155 kcal/d and thereafter until 35 mo received 200 kcal/d. The primary outcomes were change in length-for-age z score (LAZ) and improvements in a biomarker of EED, the percentage of lactulose (%L) excreted as part of the lactulose:mannitol dual-sugar absorption test. Anthropometric measurements and urinary %L excretion were compared between the 2 intervention groups and the control group separately with the use of linear mixed model analyses for repeated measures. RESULTS: A total of 331 children completed the clinical trial. Compliance with the study interventions was excellent, with >90% of the intervention flour consumed as intended. No significant effects on LAZ, change in LAZ, or weight-for-length z score were observed due to either intervention legume, compared to the control. %L was reduced with common bean consumption (effect estimate was -0.07 percentage points of lactulose, P = 0.0007). The lactulose:mannitol test was not affected by the legume intervention. CONCLUSION: The addition of common bean to complementary feeding of rural Malawian children during the second year of life led to an improvement in a biomarker of gut health, although this did not directly translate into improved linear growth. This trial was registered at clinicaltrials.gov as NCT02472301 ." 148 , no. 2 (2018) : 267–274
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Robert H. J. Bandsma , Wieger Voskuijl, Emmanuel Chimwezi, Greg Fegan, André Briend, Johnstone Thitiri, Moses Ngari, Laura Mwalekwa, Victor Bandika, Rehema Ali, Fauzat Hamid, Betty Owor, Neema Mturi, James A. Berkley. "     ." PLoS Medicine 2 , no. 16 (2019)
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • SAM