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This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 25 of 26 Results
Mangani, C., Manary, M., Alho, L., Ashorn, P.. "A single-centre, randomized, single-blind, parallel group clinical trial in rural Malawi, testing the growth promoting effect of long-term complementary feeding of infants with a high-energy, micronutrient fortified spread ." FANTA Project (2012)
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • MAM
Prado, E. L., Maleta, K., Ashorn, P., Ashorn, U., Vosti, S. A., Sadalaki, J., Dewey, K. G.. "Effects of maternal and child lipid-based nutrient supplements on infant development: a randomized trial in Malawi ." American Journal of Clinical Nutrition 103 , no. 3 (2016) : 784-793
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
Trehan, I., Banerjee, S., Murray, E.. "Extending supplementary feeding for children younger than 5 years with moderate acute malnutrition leads to lower relapse rates ." Journal of Pediatric Gastroenterology & Nutrition 60 , no. 4 (2015) : 544-549
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Cheung, Y. B., Xu, Y., Mangani, C., Fan, Y. M., Dewey, K. G., Salminen, S. J., Maleta, K., Ashorn, P.. "Gut microbiota in Malawian infants in a nutritional supplementation trial ." Tropical Medicine & International Health 21 , no. 2 (2015) : 283-90
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
  • Plant-source protein
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • MAM
Kodish, S., Aburto, N., Hambayi, M. N., Kennedy, C., Gittelsohn, J.. "Identifying the sociocultural barriers and facilitating factors to nutrition-related behavior change formative research for a stunting prevention program in Ntchisi, Malawi ." Food and Nutrition Bulletin 36 , no. 2 (2015) : 138-153
Study Interventions
  • Behavior change communication (BCC)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Stunted
Flax, V. L., Bentley, M. E., Chasela, C. S., Kayira, D., Hudgens, M. G., Kacheche, K. Z., Chavula, C., Kourtis, A. P., Jamieson, D. J., van der Horst, C. M.. "Lipid-based nutrient supplements are feasible as a breastmilk replacement for HIV-exposed infants from 24 to 48 weeks of age ." The Journal of Nutrition 143 , no. 5 (2013) : 701-707
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women
Hemsworth, J., Kumwenda, C., Arimond, M., Maleta, K., Phuka, J., Rehman, A. M., Vosti, S. A., Ashorn, U., Filteau, S., Dewey, K. G., Ashorn, P., Ferguson, E. L.. "Lipid-based nutrient supplements increase energy and macronutrient intakes from complementary food among Malawian infants ." The Journal of Nutrition 146 , no. 2 (2016) : 326-34
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Stunted
Ashorn, U., Alho, L., Arimond, M., Dewey, K. G., Maleta, K., Phiri, N., Phuka, J., Vosti, S. A., Zeilani, M., Ashorn, P.. "Malawian mothers consider lipid-based nutrient supplements acceptable for children throughout a 1-year intervention, but deviation from user recommendations is common ." The Journal of Nutrition 145 , no. 7 (2015) : 1588-1595
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Stunted
Mangani, C., Cheung, Y. B., Maleta, K., Phuka, J., Thakwalakwa, C., Dewey, K., Manary, M., Puumalainen, T., Ashorn, P.. "Providing lipid-based nutrient supplements does not affect developmental milestones among Malawian children ." Acta Paediatrica 103 , no. 1 (2014) : e17-26
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Maleta, K. M., Phuka, J., Alho, L., Cheung, Y. B., Dewey,K. G., Ashorn, U., Phiri, N., Phiri, T. E., Vosti, S. A., Zeilani, M., Kumwenda, C., Bendabenda, J., Pulakka, A., Ashorn, P.. "Provision of 10–40 g/d lipid-based nutrient supplements from 6 to 18 months of age does not prevent linear growth faltering in Malawi ." The Journal of Nutrition 145 , no. 8 (2015) : 1909-15
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Ashorn, P., Alho, L., Ashorn, U., Cheung, Y. B., Dewey, K. G., Gondwe, A., Harjunmaa, U., Lartey, A., Phiri, N., Phiri, T. E., Vosti, S. A., Zeilani, M., Maleta, K.. "Supplementation of maternal diets during pregnancy and for 6 months postpartum and infant diets thereafter with small-quantity lipid-based nutrient supplements does not promote child growth by 18 months of age in rural Malawi: A randomized controlled trial ." The Journal of Nutrition 145 , no. 6 (2015) : 1345-53
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women
Ashorn, P., Alho, L., Ashorn, U., Cheung, Y. B., Dewey, K. G., Harjunmaa, U., Lartey, A., Nkhoma, M., Phiri, N., Phuka, J., Vosti, S. A., Zeilani, M., Maleta, K.. "The impact of lipid-based nutrient supplement provision to pregnant women on newborn size in rural Malawi: a randomized controlled trial ." The American Journal of Clinical Nutrition 101 , no. 2 (2015) : 387-97
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women
Arimond, M., Zeilani, M., Jungjohann, S., Brown, K. H., Ashorn, P., Allen, L. H., Dewey, K. G.. "Considerations in developing lipid-based nutrient supplements for prevention of undernutrition: experience from the International Lipid-Based Nutrient Supplements (iLiNS) Project ." Maternal & Child Nutrition 11 , no. S4 (2015) : 31-61
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Stunted
Klevor, M. K., Adu-Afarwuah, S., Ashorn, P., Arimond, M., Dewey, K. G., Lartey, A., Maleta, K., Phiri, N., Pyykko, J., Zeilani, M., Ashorn, U.. "A mixed method study exploring adherence to and acceptability of small quantity lipid-based nutrient supplements (SQ-LNS) among pregnant and lactating women in Ghana and Malawi ." BMC Pregnancy and Childbirth 16 , no. 1 (2016) : 253
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Acceptability
  • Use
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women
Thakwalakwa, C. M., Ashorn, P., Phuka, J. C., Cheung, Y. B., Briend, A., Maleta, K. M.. "Impact of lipid-based nutrient supplements and corn-soy blend on energy and nutrient intake among moderately underweight 8-18-month-old children participating in a clinical trial.  ." Maternal & Child Nutrition 11 , no. S4 (2015) : 144-150
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Efficacy
Nutritional Problems being Studied
  • Stunted
  • MAM
Oaks, B. M., Young, R. R., Adu-Afarwuah, S., Ashorn, U., Jackson, K. H., Lartey, A., Maleta, K., Okronipa, H., Sadalaki, J., Baldiviez, L. M., Shahab-Ferdows, S., Ashorn, P., Dewey, K. G.. "Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials ." Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) 117 (2017) : 28-35
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Nutritional Problems being Studied
  • Stunted
Wang, A. Z., Shulman, R. J., Crocker, A. H., Thakwalakwa, C., Maleta, K. M., Devaraj, S., Manary, M., Trehan, I.. "A combined intervention of zinc, multiple micronutrients, and Albendazole does not ameliorate environmental enteric dysfunction or stunting in rural Malawian children in a double-blind randomized controlled trial ." The Journal of Nutrition 147 , no. 1 (2017) : 97-103
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Kodish, S. R., Aburto, N. J., Hambayi, M. N., Dibari, F., Gittelsohn, J.. "Patterns and determinants of small-quantity LNS utilization in rural Malawi and Mozambique: considerations for interventions with specialized nutritious foods ." Maternal & Child Nutrition 13 , no. 1 (2017)
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Use
Nutritional Problems being Studied
  • Stunted
Ashorn, P., Poelman, B., Dewey, K. G., Maleta, K., Klein, N., Rogerson, S., Meshnick, S. R., The LNS-RTI Study Team. "The impact of dietary supplementation with lipid-based nutrient supplements on maternal health and pregnancy outcomes in rural Malawi ." (2017)
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women
Manary, M., Callaghan, M., Wegner, D., Papathakis, P.. "Randomized controlled trial of the impact of treating moderately malnourished women in pregnancy ." (2017)
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women
  • MAM
Lin, C. A., Manary, M. J., Maleta, K., Briend, A., Ashorn, P.. "An energy-dense complementary food is associated with a modest increase in weight gain when compared with a fortified porridge in Malawian children aged 6–18 months ." Journal of Nutrition 138 (2008) : 593-598
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Locally produced
Research Gaps
  • Composition
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • GAM
Heather C Stobaugh, Lucy B Bollinger, Sara E Adams, Audrey H Crocker, Jennifer B Grise, Julie A Kennedy, Chrissie Thakwalakwa, Kenneth M Maleta, Dennis J Dietzen , Mark J Manary, Indi Trehan. "." The American Journal of Clinical Nutrition 106 , no. 2 (2017) : 656-666
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • MAM
Agapova, S. E., Stephenson, K. B., Divala, O., Kaimila, Y., Maleta K. M., Thakwalakwa, C. Ordiz, M. I., Trehan, I., Manary, M. J.. "BACKGROUND: Chronic malnutrition, as manifested by linear growth faltering, is pervasive among rural African children. Improvements in complementary feeding may decrease the burden of environmental enteric dysfunction (EED) and thus improve growth in children during the critical first 1000 d of development. OBJECTIVE: We tested the hypothesis that systematically including common bean or cowpea into complementary feeding would reduce EED and growth faltering among children in rural Malawi. METHODS: This was a double-blind clinical trial in which children 12-23 mo of age were randomly assigned to receive complementary feeding with 1 of 3 foods: roasted cowpea or common bean flour, or an isoenergetic amount of corn-soy blend as a control food for 48 wk. Children aged 12-23 mo received 155 kcal/d and thereafter until 35 mo received 200 kcal/d. The primary outcomes were change in length-for-age z score (LAZ) and improvements in a biomarker of EED, the percentage of lactulose (%L) excreted as part of the lactulose:mannitol dual-sugar absorption test. Anthropometric measurements and urinary %L excretion were compared between the 2 intervention groups and the control group separately with the use of linear mixed model analyses for repeated measures. RESULTS: A total of 331 children completed the clinical trial. Compliance with the study interventions was excellent, with >90% of the intervention flour consumed as intended. No significant effects on LAZ, change in LAZ, or weight-for-length z score were observed due to either intervention legume, compared to the control. %L was reduced with common bean consumption (effect estimate was -0.07 percentage points of lactulose, P = 0.0007). The lactulose:mannitol test was not affected by the legume intervention. CONCLUSION: The addition of common bean to complementary feeding of rural Malawian children during the second year of life led to an improvement in a biomarker of gut health, although this did not directly translate into improved linear growth. This trial was registered at clinicaltrials.gov as NCT02472301 ." 148 , no. 2 (2018) : 267–274
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
Wataru Sato, Chie Furuta, Keiko Matsunaga, Paluku Bahwere, Steve Collins, Kate Sadler, Peter Akomo, Chrissy Banda, Elizabeth Maganga, Sylvester Kathumba, Hitoshi Murakami. "." PLoS One 13 , no. 8 (2018)
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Cambria M. Glosz, Andrew A. Schaffner, Scott K. Reaves, Mark J. Manary, and Peggy C. Papathakis. "." Nutrients 10 , no. 7 (2018) : 879
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • SAM