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This page includes publications from individual clinical trials testing food aid products, and reports and evaluations from programs using food aid products. These resources are tagged according to country, nutritional problem studied, intervention used, study type, year, and author. If relevant to more than one category, the document appears in both categories. New resources are added regularly according to search criteria and standards developed by REFINE.

Do you know of a recently published study or trial that isn’t included here? Email us at REFINEnutrition@gmail.com!


Displaying 1 - 20 of 20 Results
Ruel, M. T., Menon, P., Habicht, J., Loechl, C., Bergeron, G., Pelto, G., Arimond, M., Maluccio, J., Michaud, L., Hankebo, B.. "Age-based preventive targeting of food assistance and behaviour change and communication for reduction of childhood undernutrition in Haiti: a cluster randomised trial ." The Lancet 371 , no. 9612 (2008) : 588-595
Study Interventions
  • Behavior change communication (BCC)
  • Fortified blended foods (FBF)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • MAM
Trehan, I., Banerjee, S., Murray, E.. "Extending supplementary feeding for children younger than 5 years with moderate acute malnutrition leads to lower relapse rates ." Journal of Pediatric Gastroenterology & Nutrition 60 , no. 4 (2015) : 544-549
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Tripp, K., Clayton, H., Nanema, A., Mujinga, W., Kupka, R., Sandalinas, F., Nanama, S., Jungjohann, S., Chatelier, M. L., Palma, C.. "Formative assessment to design the packaging of a lipid-based nutrient supplement for a home fortification program to improve the nutritional status of young children in the Democratic Republic of Congo (DRC) ." (2013)
Study Interventions
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • SAM
  • MAM
Tripp, K., Perrine, C. G., de Campos, P., Knieriemen, M., Hartz, R., Jefferds, M. E., Kupka, R.. "Formative research for the development of a market‐based home fortification programme for young children in Niger ." Maternal & Child Nutrition 7 , no. Supplement 3 (2011) : 82-95
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Acceptability
Nutritional Problems being Studied
  • Stunted
  • SAM
  • MAM
Zebdewos, A., Singh, P., Birhanu, G., Whiting, S. J., Henry, C. J., Kebebu, A.. "Formulation of complementary food using amaranth, chickpea and maize improves iron, calcium and zinc content ." African Journal of Food, Agriculture, Nutrition and Development 15 , no. 4 (2015) : 10290-10304
Study Interventions
  • Locally produced
  • Plant-source protein
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Stunted
Cheung, Y. B., Xu, Y., Mangani, C., Fan, Y. M., Dewey, K. G., Salminen, S. J., Maleta, K., Ashorn, P.. "Gut microbiota in Malawian infants in a nutritional supplementation trial ." Tropical Medicine & International Health 21 , no. 2 (2015) : 283-90
Study Interventions
  • Animal-source protein
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
  • Plant-source protein
Research Gaps
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • MAM
McNulty, Judiann, Harvey, Ruth, Tilford, Kathy. "Impact study report: Comparison of PM2A and MCHN approaches in SOUHARDO II ." (2015)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • GAM
Dewey, K. G., Arimond, M.. "Lipid-based nutrient supplements: how can they combat child malnutrition? ." PLoS Medicine 9 , no. 9 (2012) : e1001314
Study Interventions
  • Animal-source protein
  • Lipid-based nutrient supplements (LNS)
  • Plant-source protein
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • SAM
  • MAM
Hess, S. Y., Abbeddou, S., Jimenez, E. Y., Somé, J. W., Vosti, Stephen A, Ouédraogo, Z. P., Guissou, R. M., Ouédraogo, J., Brown, K. H.. "Small-quantity lipid-based nutrient supplements, regardless of their zinc content, increase growth and reduce the prevalence of stunting and wasting in young burkinabe children: a cluster-randomized trial ." PloS One 10 , no. 3 (2015) : e0122242
Study Interventions
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Composition
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • GAM
Manary, M., Callaghan, M., Wegner, D., Papathakis, P.. "Randomized controlled trial of the impact of treating moderately malnourished women in pregnancy ." (2017)
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • Stunted
  • Pregnant & Lactating Women
  • MAM
Kampstra, N. A., Van Hoan, N., Koenders, D. J. P. C., Schoop, R., Broersen, C. B., Mouquet-Rivier, C., Traore, T., Bruins, M. J., de Pee, S.. "Energy and nutrient intake increased by 47–67% when amylase was added to fortified blended foods—a study among 12- to 35-month-old Burkinabe children ." Maternal & Child Nutrition (2017)
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Acceptability
  • Composition
Nutritional Problems being Studied
  • Stunted
  • GAM
Hirve, S., Martini, E., Juvekar, S. K., Agarwal, D., Bavdekar, A., Sari, M., Molwane, M., Janes, S., Haselow, N., Yeung, D. L., Pandit, A.. "Delivering Sprinkles Plus through the Integrated Child Development Services (ICDS) to Reduce Anemia in Pre-school Children in India ." The Indian Journal of Pediatrics 80 , no. 12 (2013) : 990-995
Study Interventions
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Use
Nutritional Problems being Studied
  • Stunted
  • GAM
Jessica Bliss, Kate Golden, Leila Bourahla, Rebecca Stoltzfus, David Pelletier. "." Journal of Global Health 8 , no. 1 (2018)
Study Interventions
  • Cash transfer
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • SAM
  • GAM
  • MAM
Susan B. Roberts, Maria Angela Franceschini, Amy Krauss, Pei-Yi Lin, Augusto Braima de Sa, Raimundo Co ́, SalimaTaylor, Carrie Brown, Oliver Chen, Elizabeth J. Johnson, William Pruzensky, Nina Schlossman, Carlito Bale ́, Kuan-Cheng (Tony) Wu, Katherine Hagan, Edward Saltzman, Paul Muentener. "." Current Developments in Nutrition 1 , no. 11 (2017)
Study Interventions
  • Fortified blended foods (FBF)
  • Locally produced
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Heather C Stobaugh, Lucy B Bollinger, Sara E Adams, Audrey H Crocker, Jennifer B Grise, Julie A Kennedy, Chrissie Thakwalakwa, Kenneth M Maleta, Dennis J Dietzen , Mark J Manary, Indi Trehan. "." The American Journal of Clinical Nutrition 106 , no. 2 (2017) : 656-666
Study Interventions
  • Fortified blended foods (FBF)
  • Lipid-based nutrient supplements (LNS)
  • Micronutrient powders (MNP)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • MAM
Isanaka S, Barnhart DA, McDonald CM, Ackatia-Armah RS, Kupka R, Doumbia S, Brown KH, Menzies NA.. "." BMJ Global Health 4 , no. 2 (2019)
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • SAM
Taylor S, Silver R, Franceschini M, Muentener P, de Sa AB, Co R, Sonco A, Balé C, Saltzman E, Roberts S.. "  OBJECTIVES: Undernutrition is prevalent among young children worldwide and is associated with impaired cognition and reduced educational attainment. We conducted a randomized controlled trial to test the effect of a novel supplementary food (regenerative nutrition for enhanced wellness-cognition; RENEW-C) compared to traditional feeding practices on cognitive function, cerebral blood flow and oxygen metabolism in rural Guinea-Bissau. METHODS: Children aged 15 months to 7 years (n = 1059) were randomized to receive isocaloric quantities of RENEW-C (a highly-fortified cocoa-based bar), a USAID fortified blended food (FBF) or a Control food (rice cooked with oil, replicating a traditional breakfast). The primary outcome was executive function. Secondary outcomes included a cerebral blood flow index (CBFi) and cerebral metabolic rate of oxygen (CMRO2) measured by Frequency-Domain Near-Infrared Spectroscopy and Diffusion Correlation Spectroscopy (FDNIRS-DCS, MetaOx, ISS Inc.). Six-month changes for RENEW-C and FBF versus Controls were assessed by multivariable linear mixed models adjusted for age, sex, baseline measurement, and study cohort. RESULTS: Improvements in executive function (0.38; 95% CI: 0.10, 0.71; P = 0.02) were observed for RENEW-C compared to Controls in the predefined study focus (children < 4 years consuming >75% their supplement). There was no significant effect of RENEW-C in children ≥ 4 years. No benefit of the FBF was observed in either age group. In addition, changes in CBFi and CMRO2 in RENEW-C children were greater than in Controls in both ventrolateral prefrontal cortical regions (P = 0.03 and P = 0.04 for left and right, respectively) and greater than FBF in the left ventrolateral (P = 0.05) and left dorsolateral (P = 0.03) prefrontal cortices. CONCLUSIONS: Compared with traditional feeding practices, the RENEW-C supplement consumption was correlated with a marked improvement in executive function among children < 4 years and large increases in vascular perfusion and oxygen metabolism in a region where undernutrition is prevalent. These results indicate that new approaches to formulating supplementary foods for children at risk of undernutrition can potentially yield substantial improvements in brain health and cognition. ." Current Developments in Nutrition 3 , no. Supp 1 (2019)
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • Stunted
  • MAM
. "." Journal of Human Nutrition and Dietetics 32 , no. 3 (2019) : 295-302
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Effectiveness
  • Innovation
Nutritional Problems being Studied
  • MAM
Shen Y, Griswold S, Langlois B, Suri D, Vosti S, Webb P, Rogers B.. "." Current Developments in Nutrition 3 , no. Supp 1 (2019) : P10-140-19
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Effectiveness
Nutritional Problems being Studied
  • MAM
Shen Y, Griswold S, Langlois B, Suri D, Vosti S, Webb P, Rogers B.. "." Current Developments in Nutrition 3 , no. Supp 1 (2019) : P10-142-19
Study Interventions
  • Fortified blended foods (FBF)
Research Gaps
  • Cost
  • Effectiveness
Nutritional Problems being Studied
  • MAM