How well do different food compositions and interventions prevent or treat undernutrition, when implemented "on the ground"?

Supporting Literature: 
  • World Health Organization. "Technical note: supplementary foods for the management of moderate acute malnutrition in infants and children 6–59 months of age." (2012).
  • Suri, D., et al. (2013). "Protein Quality Workshop: Importance of Protein Quality in Prevention and Treatment of Child Malnutrition." Food & Nutrition Bulletin 34 (2): 223-223.
  • 2013 Maternal and Child Nutrition series - The Lancet
  • Webb, Patrick. "Standards of Evidence for Research on ‘What Works’ in the Management of MAM." (2014).
  • Annan, Reginald A., Patrick Webb, and Rebecca Brown. "Management of Moderate Acute Malnutrition (MAM): Current Knowledge and Practice."(2014).
  • Webb, Patrick, Erin Boyd, Saskia de Pee, Lindsey Lenters, Martin Bloem and Werner Schultink. "Nutrition in Emergencies: Do We Know What Works?" Food Policy 49,  (2014): 33-40.

A Multi-center, Randomized Controlled Comparison of Three Renutrition Strategies for the Management of Moderate Acute Malnutrition Among Children From 6 to 24 Months (Madagascar, Niger, Central African Republic and Senegal)

The aim of this open-label randomized controlled trial conducted in four African countries (Madagascar, Niger, Central African Republic and Senegal) is to compare three strategies of renutrition for moderate acute malnutrition (MAM) in children based on modulation of the gut microbiota with enriched flours alone, enriched flours with prebiotics or enriched flours coupled with antibiotic treatment. Cognitive development of children (Senegal) will also be studied and compared.

Effectiveness of Multiple Micro-nutrient Fortified Fudge on Nutritional Status of 3-5 Years of Age Children

Multiple micro-nutrient deficiencies in Pakistan is wide spread, there is dire need to address these by using smart solutions, among them multiple fortified product (fudge) is an alternate possible way to address this issue. Fortified products have the potential to reduce micronutrient deficiencies in children, therefore in current study children from 3-5 years will receive fortified product along with enhance nutrition promotional information to bring change in their dietary practices and nutritional indices.

Comparison of an Alternative Therapeutic Food for the International Food Aid Market to a Standard Ready-to-use Therapeutic Food (RUTF) for the Treatment of Severe Acute Malnutrition in Children

In this clinical equivalency trial, two foods will be compared for the treatment of SAM, testing the hypothesis that the difference in recovery rates and growth between the two test groups will be no greater than 5 percent.

This will be a randomised, double-blinded, controlled clinical equivalency trial assessing the treatment of SAM with one of two therapeutic foods until the child is recovered or for a period of up to 12 weeks.

Effect of Double Fortification (Iron and Zinc) in Synbiotic Milk to Under 5 Years Stunted Children Growth

The purpose of this study is to investigate the effects of double fortification (iron and zinc) in synbiotic milk (L.plantarum Dad13 and fructooligosaccharides) on under 5 years stunted children growth, gut microbiota composition, blood zinc and hemoglobin level, and cognitive level.

Evaluating the effectiveness of a legume-enriched nutritional intervention, in treatment of severe undernutrition in children

Severe acute malnutrition is a serious illness and a common problem. In malnutrition, the gut becomes damaged and does not function properly. This means a lot of the food is lost in the stool, sometimes as diarrhoea, and not enough food gets into the body. Healthy bacteria live in the gut and do not cause any illness, but the types of bacteria may change in malnutrition to ones that can cause serious infections. Good bacteria use food that the body cannot digest (fibre/roughage) and turn it into helpful products.

Comparison of a Two Ready-to-use Supplementary Foods of Differing Protein Quality for the Treatment of MAM.

This is a prospective, randomised, double-blinded, controlled clinical effectiveness trial of two supplementary foods in the treatment of MAM. The setting will be 21 rural sites in southern Malawi. The participants will be 1800 children 6-59 months old with MAM, defined as mid-upper arm circumference (MUAC) ≥ 11.5 cm and < 12.5 cm and/or a weight-for-height Z-score (WHZ) between -2 and -3 without bipedal edema. Children will receive approximately 75 kcal/kg/d (314 kJ/kg/d) of one of two RUSFs in two-week rations for outpatient therapy of MAM.

Effectiveness of SNF, Cash and BCC to Prevent Stunting Among Children 6-24 Months in Rahim Yar Khan, Pakistan

Malnutrition is a public health problem, with long-lasting physiological consequences and increased risk of morbidity and mortality. It can be recognized as one of the key obstacles in national development, due to its influence on individual productivity, school performance and physical work capacity. Malnutrition is a hidden crisis in Pakistan, with rates increasing during the last decade. High prevalence of food insecurity, illiteracy, lack of nutritional knowledge, poor hygiene status, and under recognized role of nutrition are some of the possible causes.

SPOON: Sustained Program for Improving Nutrition - Guatemala

The primary goal of the study is to prevent undernutrition and obesity in children under two years old in rural areas of Guatemala. This study is designed to evaluate whether the proposed treatment reduces the prevalence of overweight, underweight and low height-for-age indicators in the rural environment of Baja Verapaz. This study design has been developed in conjunction with colleagues from Fundazúcar, a local foundation in Guatemala.

SPOON: Sustained Program for Improving Nutrition - Colombia

The primary goal of this study is to prevent undernutrition and obesity in peri-urban areas of Colombia. This study is designed to evaluate the impact of promoting adequate feeding practices and the use of SQ-LNS (Small Quantity Lipid-Based Nutrient Supplements) on the nutritional status of infants and young children. The study will be conducted in peri-urban areas of Pasto, Colombia in conjunction with Fundación Saldarriaga Concha and the Colombian Ministry of Health and Social Protection.