What novel food-based products and programming methods effectively prevent and treat undernutrition?

Supporting Literature: 
  • Webb, Patrick, Beatrice Lorge Rogers, Irwin Rosenberg, Nina Schlossman, Christine Wanke, Jack Bagriansky, Kate Sadler, Quentin Johnson, Jessica Tilahun, Amelia Reese Masterson, Anuradha Narayan. 2011. Improving the Nutritional Quality of U.S. Food Aid: Recommendations for Changes to Products and Programs. Boston, MA: Tufts University.
  • 2013 Maternal and Child Nutrition series - The Lancet
  • Shoham, Jeremy, et al. "Proceedings of the World Health Organization/UNICEF/World Food Programme/United Nations High Commissioner for Refugees Consultation on the management of moderate malnutrition in children under 5 years of age." Food and nutrition bulletin. Vol. 30. No. 3 (Supplement). United Nations University Press, 2009.
  • Stone-Jimenez, Maryanne. "Preventing Moderate Acute Malnutrition (MAM) Through Nutrition-Specific Interventions." (2014).
  • Webb, Patrick. "Standards of Evidence for Research on ‘What Works’ in the Management of MAM." (2014).
Long Description: 

- Are cash transfers better than food aid alone?
- Does including a behavior change communication aspect in food aid programs lead to better outcomes?
- Can locally produced foods reduce undernutrition?

Feeding malnourished children different types of fatty acids to promote neurocognitive development

An appropriate balance of omega-6 and omega-3 fatty acids is important for support of neurocognitive development in healthy infants and toddlers. In young children recovering from severe acute malnutrition (SAM), excess omega-6 intake depletes omega-3 fatty acid status. This research will evaluate how novel ready-to-use therapeutic foods (RUTF) with balanced fatty acids improve the metabolic and neurocognitive effects in young children in Malawi recovering from SAM, yielding new knowledge that also has implications for development of well-nourished children.


The ready-to-use supplementary food's impact on indicators of malnutrition in mild and moderately wasted children: a randomized controlled trial

This study is a randomized controlled clinical trial, and 106 children will be studied for eight weeks. Inclusion criteria are having age 24 to 59 months; mild and moderate malnutrition without edema (Anthropometric index of weight for height between the -1 and -3 z-score); filling a consent form. Exclusion criteria are being twins; food allergies and intolerance; severe anemia; liver-kidney disease; malabsorption syndrome; unwillingness to cooperate. After enrollment, children will be allocated into two groups (Intervention and Control groups) based on random number table.

Efficacy of three feeding regimens for home-based management of children with uncomplicated severe acute malnutrition: a randomised trial in India

Efficacy of three feeding regimens for home-based management of children with uncomplicated severe acute malnutrition: a randomised trial in India

Nutritional and anti-infective interventions for malnutrition in pregnancy (Beleuman Welbodi)

Acute malnutrition in pregnancy is a risk factor for adverse outcomes in mothers and their unborn children. Undernutrition during pregnancy can result in maternal complications such as life-threatening hemorrhage and hypertensive disorders of pregnancy and infant complications such as intrauterine growth retardation, low birth weight, pre-term delivery and poor cognitive development.

Integrated treatment protocol for acute malnutrition: A non inferiority trial in Burkina Faso (MUAC-Only)

MUAC only is a non-inferiority trial with external control carried out between January 2017 and December 2017 in the Yako district (northern region), Burkina Faso.

The objective of this study is to evaluate an integrated protocol for acute malnourished children without medical complication. The hypotheses of the integrated protocol include :

Locally prepared supplement to support growth and brain health

This study is a randomized controlled trial with a main goal to assess the effects of a locally-prepared food for prevention of malnutrition and stunting, in comparison with standard village practices and also a widely available aid food supplement in 8-12 villages in Guinea-Bissau. The supplement intervention will be for 24-30 weeks. The primary outcome will be cognitive tests of executive function. Secondary outcomes will be changes in standard anthropometric benchmarks of growth, hemoglobin and skin carotenoids in young children living in villages in rural Guinea-Bissau.

Benefits of a Household WASH Package to Community-based Management of Acute Malnutrition (CMAM) Program, Chad (OUADINUT)

The objective of the research is to assess the effectiveness of adding a Household WASH component to the standard outpatient treatment of severe acute malnutrition.

Study design: cluster-randomized controlled trial comparing two interventions:

Combined protocol for acute malnutrition study (ComPAS)

Acute malnutrition in children under 5 is defined by being too thin for a given height and/or having the left arm circumference less than a given threshold (i.e. measuring how fat or thin the mid upper arm circumference (MUAC) is), and/or having swollen feet (malnutrition oedema). It affects 19 million children under five at any point in time, and can result in death if left untreated. Currently, children can receive treatment for uncomplicated acute malnutrition through outpatient treatment programs.